Nathaniel Bloom

New review! @skleinstein and I cover how B cell lineage trees are built using single cell VDJ data, and how they can be used to study B cell evolution, differentiation, and temporal dynamics during immune responses. Free access link: authors.elsevier.com/a/1iKBp5Eb0Rtz…

The latest from our lab @BarouchLab on mucosal vaccination for respiratory pathogens! Out in @Nature today, we show that boosting by intratracheal route enhances mucosal immune responses and provides complete protection from infection! Go give it a read! nature.com/articles/s4158…

The Myth of Ethidium Bromide | Science | AAAS science.org/content/blog-p…

If anyone is wondering what I want for Christmas. #cytometry #immunology

A spatial transcriptomics–based technology co-captures B and T cell receptors within their anatomical niches in human tissue @ScienceMagazine @FrisenJonas @Jeff_Mold @camillaengblom @Qirongliiin @thrane_kim science.org/doi/10.1126/sc…

Give them wings to fly #academictwitter nature.com/articles/d4158…

Live attenuated influenza vaccine induces disparate Ab responses in the mucosa and blood associated with distinct immune responses early post-inoculation, w/ IL-33 limiting peripheral Ab but enabling mucosal IgA @p_openshaw @InThwaiteImmune nature.com/articles/s4146…

Out today @NatureComms, we show the distinction of mucosal and systemic antibody responses to live attenuated flu vaccine (LAIV) in humans and distinct mucosal immune mechanisms behind these separate humoral outcomes 📢🧵nature.com/articles/s4146…

No IKAROS, no antibodies. LJI and @harvardmed scientists map the genome to figure out how a protein called IKAROS controls healthy B cell development: bit.ly/47zJkpG @ferhatay @CellCellPress #Bcells #antibodies #immunology #health #bioinformatics

@camilahcoelho 😎

Meet LJI's "Highly Cited Researchers!" These #SanDiego scientists are advancing #VaccineResearch #Compbio and more! 🧵👇 @ClarivateAG #HighlyCited2023 #HighlyCited #LaJolla #health #science #vaccines #bioinformatics #Tcells #antibodies #DataScience

Three protective Abs that cross-react with neuraminidases from seasonal H3N2 strains spanning multiple decades with implications for developing broadly protective influenza vaccines @wchnicholas @ImmunityCP cell.com/immunity/fullt…

GC | A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates dlvr.it/SyQ6B5

Nucleic acid vaccine responses are regulated by the microbiome @J_Immunol @KublinMD doi.org/10.4049/jimmun…

Thanks to immigrants, the US won 75% of Nobel prizes in 2023. Without them, we only would have won 25%. High skilled immigration is a policy lever for more innovation unlike anything else. Oh and its free.

🚨New paper alert! Following on from our recent work showing that Bmi-1 is an important regulator of plasma cells, our new study provides evidence that BMI-1 may also be a viable therapeutic target to deplete plasma cells in autoimmunity: onlinelibrary.wiley.com/doi/full/10.10…

Last week we had a 75th bday symposium for my mentor Rafi Ahmed. His closing words should be a motto for all we do: "This is my message to you: whatever you do, being a good human being is the most important"

Now online! Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth dlvr.it/SwvP7F

@camilahcoelho 😂😂

Why Thousands of #Octopuses Are Snuggled Up Against a Deep-Sea Heater 🐙🐙🐙🔥 ow.ly/baxH50PCzI1 ✒️: Anushuya Thapa 📷 (multiple): 2019-2022 MBARI @MBARI_News #octopus #marinescience #marineecology #marineinvertebrates #octopusgarden #montereybay