The Boulton Lab

Similar results are obtained by independent labs @makotothayashi2 in Kyoto University/IFOM and @ZierLab at ICR.

Cells retained the ability to activate cGAS-STING in response to dsDNA or modified vaccinia virus infection. We provide evidence that micronuclei formed by genotoxic insults contain histone-bound self-DNA, which is inhibitory to cGAS activation. Link below tinyurl.com/nhdn8ts7

Our latest is out! 🥳We found cGAS engaged w/ ruptured micronuclei can't activate downstream signalling. Our observation challenges current dogma that cGAS binds to self-DNA in micronuclei and triggers innate immune signalling. Spearheaded by Tohru @Wgctt1 with @Rhona_mill.

Long story short… 🧬 Amazing science in Rome, making ends meet, forza telomeres! @TeloEMBO2024

We have great news - our postdocs @MartinaPeritore and @RRJLow have been awarded #MSCA postdoctoral fellowships!! Congratulations 🥳🙌🏾👩🏾‍🔬👨🏾‍🔬 Looking forward to the exciting science to come!

@BoultonLab closes day 3 with a fabulous two part Plenary talk on ALT and the EXO1 story!! We hope to announce an exciting collaboration with Simon very soon… watch this space 🧬 #DRRSC24

In summary, we observed human BRCA2 is capable of nucleating RAD51 either directly onto ssDNA or ds-ssDNA junction; or via diffusion-assisted delivery aided by sliding along dsDNA. This work was a great collaborative effort between @BoultonLab, @SCWestLab and others. (10/10)

BRCA2 is mutated in breast and ovarian cancer. W/ help from Lucas Kuhlen (Xiaodong Zhang lab @ICStructBio) & @roopesh_anand we observed that BRCA2 truncations were impaired for RAD51 nucleation or sliding. C-terminus loss made BRCA2-DNA interaction particularly labile! (9/10)

Our latest📰! Out today in @MolecularCell We used single-molecule imaging to directly observe human BRCA2 tumour suppressor in action! Spearheaded by @BelanOndrej & @LukeGreenhough. A thread. (1/10) sciencedirect.com/science/articl…

We have open postdoctoral positions at Columbia University funded by our NIH T32 grant! If you are interested in studying genome or epigenome integrity, come and join us!

Congratulations to Prof Sir Steve Jackson on receiving a knighthood in the King's #BirthdayHonoursList for @SPJacksonGroup's pioneering research on the DNA damage response and its translation into the clinic. Well deserved, Steve! 👨‍🔬🧪🧬🎉🥳

“The vision of Radnet was to bring in a new generation of researchers w/ skillsets that we could apply to study the problem of #radiation, which is a big opportunity for cancer treatment.” Hear more from Simon Boulton, Director @RadNetCRUKCoL: bit.ly/3WxhZhH