Lu Lab_Columbia

@bsabari @MichaelMShen @califano_lab Thanks Ben!

@LuLaboratory @MichaelMShen @califano_lab Congrats, Chao!

Here we go! Excited to share our latest collaborative work with @MichaelMShen and @califano_lab. We uncovered that NSD2-catalyzed H3K36me2, a histone mark dearest to our lab, is critical for lineage plasticity and resistance to anti-androgen in prostate cancer.

Further, recent work from Gozani, Mazur, Majewski and Jaremko labs demonstrates therapeutic benefit of NSD2 inhibitor in preclinical models of lung and pancreatic cancers, suggesting a broad role of H3K36me2 in cancer chromatin plasticity: nature.com/articles/s4158…

While there is still a lot to learn about the underlying mechanism, these findings suggest the therapeutic potential of combining NSD2 inhibitor with AR inhibitor in treating aggressive prostate tumors. A clinical study is already ongoing: clinicaltrials.gov/study/NCT07103…

@jdlicht @VAInstitute Congrats Jon! What a great news.

I am excited to announce that after a decade of service to the U of Florida during which the UF Health Cancer Center received NCI designation, in January 2026 I will be assuming the role of President and Chief Scientific Office of the @VAInstitute vai.org/article/eminen…

Symposium Registration Deadline Friday! - NYC Chromatin Club - mailchi.mp/cbee4a4e6267/r…

Registration - NYC Chromatin Club - July 15, 2025 - mailchi.mp/c3d82b17e5c0/r…

Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May: findaphd.com/phds/project/f… Excited to collaborate with @Hannah_K_Long and @bunina_daria (@EdinUni_IGC @MDC_Berlin). Please share 🙏 #epigenetics

@black_pine_tree Awesome - congrats Luke and Tom!

@gamzeandgursoy @NAR_Open Congrats Gamze, Carlos and Narjis!

Super excited to share the first 3D genome paper from my lab at @NAR_Open , led by my smart and hardworking student Carlos (joint with @LuLaboratory) with assists from a brilliant summer intern Narjis. (1/n) academic.oup.com/nar/article/53…

Excited to share this review on chromatin-metabolism crosstalk, lead by our star student Varun Sahu. Here, Varun summarizes the molecular principles governing metabolite-chromatin interaction & highlights emerging technologies that could advance the field. There’re lots to learn!

Check out this important work - congrats to KJ, Victoria and the team!

Please Repost- Excited to be recruiting @CeiFccc @FoxChaseCancer #epigenetic #faculty to continue building our energetic, interactive, supportive #collegial environment Our goal- Basic Discovery & help translate to positively impact patients Apply here- jobs.sciencecareers.org/job/665030/fac…

@XR_Lab Wow! Congrats and all the best with the move!

🚀 Thrilled to announce my lab has moved to UNC Charlotte, a vibrant and rapidly growing university! Huge thanks to my colleagues, collaborators, and friends for their support over the years. Excited for this new chapter and the great science ahead! 🌟🔬

@Goodell_Lab @KristjanGretars Thank you Peggy!

@LuLaboratory Congrats to @LuLaboratory , @KristjanGretars and the team for an illuminating new chapter for the N-term of #DNMT3A! Beautiful work!

Here we go - our preprint on the interplay between DNMT3A and polycomb H2AK119Ub mark is published. We believe these findings offer a potential mechanism driving DNA hypermethylation in cancer. Pls see tweetorial for more details. science.org/doi/10.1126/sc…

@sproul_lab Thank you and we really like your DNMT3B study!

@LuLaboratory Congrats all, nice to see the paper version of this cool study out.

@joshuagruber Thanks Josh! Hope all is well!

@LuLaboratory Congrats Chao and lab !

@maxvcg @KristjanGretars Thank you Maxim!

@LuLaboratory Congrats @KristjanGretars and @LuLaboratory ! Such an interesting aspect of DNAme biology you are exploring.

Lastly, shoutout to two other papers that characterize the interaction between DNMT3A and H2AK119Ub nucleosome. nature.com/articles/s4146…  by Jikui Song and Greg Wang groups. biorxiv.org/content/10.110…  by @mdrwilson group.

Congrats again to @KristjanGretars @Xagbomson Susan Gloor, Dan Weinberg, @KJArmache @GCloner @epicypher and everyone involved! Thanks to the reviewers and editor @ScienceAdvances for improving our manuscript.