Derrick Matthew Buchanan PhD Neuroscience

April 13 I'll be giving a @TEDx Talk @Stanford about Precision Brain Stimulation and the Future of Psychiatry. About 50% of patients try therapy and medication with no success, brain stimulation offers a new hope 🧠 @StanfordMed @TEDxStanford @TEDTalks @brainstimj #MentalHealth

Fantastic article on Australia’s MDMA-assisted therapy program. Already ~200 patients have received treatment with no serious adverse events reported. Early signals also suggest MDMA therapy may have more durable effects than psilocybin. Fascinating to watch this real-world data emerge. I hope our FDA will soon approve this life saving therapy for the 13 million US citizens suffering with PTSD. Cc @DrMakaryFDA

@foxmdphd @Brain_Circuits @harvardmed Congratulations Mike this is such an important time for this!

What’s the difference between a neurological vs psychiatric disorder? @Brain_Circuits, it’s only the circuit impacted. Honored to become one of the first full Professors of both Psychiatry and Neurology @harvardmed. Excited to help bridge this divide.

Impressive results @ataibeckley re BPL-003: 76% remission after just 2 doses (8mg+12mg) after 2 mo. in Ph2B. Higher than other interventional psychiatry tx such as accelerated TMS, requiring less time. But why use 8mg+8mg in prospective Ph3 study (instead of 8+12mg)? Use of 4mg as a control also sounds risky, might lack 'dose-response' effects. Any insights @C_Angermayer ?

Join us in Lyon, France in 2027!

New study by Meikle et al. reveals how pulse trains shape cortical responses: increasing pulse quantity reduces post-stimulation inhibition while current amplitude drives excitatory response—key insights for optimizing Neural prostheses. brainstimjrnl.com/article/S1935-…

Mitochondria have their own genomes. New study shows mitochondrial DNA content increases with age, especially over 45 & linked to methylation changes on both mitochondrial and nuclear DNA. Fascinating data that fits well with the Information Theory of Aging (ITOA)... 🧵

First UK participant 🇬🇧

New in @brainstimj: Hengda He et al. use concurrent fMRI-EEG-TMS to show L-DLPFC TMS acutely modulates control & default mode networks, with state-dependent effects via prefrontal alpha phase. Baseline TMS network responses predict outcomes for TRD! brainstimjrnl.com/article/S1935-… #TMS

P3, the first ventilated ALS participant enrolled in PRIME (@ALScyborg), gave an inspiring talk at the ALS Arizona Vendor Fair last week. Huge thanks to Taryn and @ALSAZ for bringing everyone together and for all the work they do to serve the ALS community. These moments put everything into perspective 🫶🏼

Nonhallucinogenic psychoplastogens have antidepressant-like effects and promote cortical neuroplasticity through the same biochemical pathway as classic psychedelics, but don't cause immediate glutamate burst or IEG activation @DEOlsonLab @UCDavisIPN nature.com/articles/s4159…

Moving to a four-day work week without losing pay leaves employees happier, healthier and higher-performing go.nature.com/44YXL6E

Most viewed this week from @JAMAPsych: Systematic review and meta-analysis: Stopping antidepressants leads to slight symptom increases compared to placebo, but these symptoms are not clinically significant and do not include mood changes. ja.ma/40fpWg6

Today, @NIH announced a new policy to cap how much publishers can charge NIH-supported scientists to make their work publicly accessible. This reflects our broader effort to restore public trust in public health by creating an open, honest, and transparent research atmosphere. Read more ➡️ bit.ly/4nCdIbl

Systematic review and meta-analysis: Stopping antidepressants leads to slight symptom increases compared to placebo, but these symptoms are not clinically significant and do not include mood changes. ja.ma/4lNdBIu

📷 3-Year Postdoc in Cognitive Neuroscience at @BottiniLab, CIMeC, University of Trento! 📷 Memory, attention, eye movements, and cognitive maps INFO: drive.google.com/file/d/1WGEEpl… DEADLINE TO APPLY JULY 9TH - BUT FLEXIBLE START AT END 2025 OR SPRING 2026!

Incredible team effort! 🧠⚡️First iEEG proof of DLPFC→sgACC connectivity via TMS. Proud to be part of this milestone study! @jingjiang_psy @boeslab @NickTrapp13 @KellerStanfordU @StanfordBrain

Out now in @brainstimj from @NolanRyWilliams & crew - important technical breakthrough in interleaved TMS - how cool is this… sciencedirect.com/science/articl…