Caleb Moulema 🇨🇲

@TEDTalks @TEDx TEDNext.

We're going around the Moon. Come watch with us. Artemis II's four-astronaut crew is lifting off from @NASAKennedy on an approximately 10-day mission that will bring us closer to living on the Moon and Mars. The launch window opens at 6:24pm ET (2224 UTC). twitter.com/i/broadcasts/1…

We are  excited   to share new paper led by the talented @NicoleScottHew1 that a microglial C1q, can be  internalized by neurons in the healthy aging brain, undergoes liquid-liquid phase separation (LLPS), integrates into neuronal RNPs and impacts neuronal proteostasis 1/3

Science life is a roller coaster.. celebrate and enjoy the good days and moments, they make up for all the bumps and challenges 10 fold. :-) happy friday !

TEDxHarvardUniversity Speakership Applications will be LIVE TOMORROW at 12PM EST. And yes, we will consider both affiliated & non-affiliated applicants. Follow our socials for important updates ig/x: @tedxharvardu !! #HopeForAllMankind24 #tedxharvarduniversity #tedx

for what could be more important than hope?

It is with an unbelievably heavy heart that I write that my husband, best friend, and partner in crime for 20 years, Larry Young, passed away unexpectedly. I will share details regarding a memorial service once I know something. Please share with those who knew Larry @lyoun03

Ending the symposium with two poster awards! A Vertex Postdoctoral Award and one for the Microbiology, Immunology, Genetics, or Molecular Biology category 🥳 Am I a basic scientist now? 🧬🫣 Thanks again to @HMS_DICP and @bscp_now for putting on a phenomenal #NESS2024!

'Unraveling the dual nature of brain CD8+ #Tcells in #AlzheimersDisease' Dan Hu & Howard L. Weiner @weinerlabhms @BrighamWomens @harvardmed #microglia …arneurodegeneration.biomedcentral.com/articles/10.11…

Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hyperplasticity, immune activation, RNA metabolism, choroid plexus or blood-brain barrier function. Subtypes may need tailored cures. doi.org/10.1038/s43587…

I’m thrilled to share the results of a phenomenal collaboration with Lasse Dissing-Olesen in the @stevens1lab. If you’re hungry for microglial biology and looking for a new set of utensils with which to dig in, please read on. nature.com/articles/s4146… 1/n

On the eve of my first day of residency, I’m excited to share (belatedly) that my PhD work has finally been published! Below, learn more about our strategy to create a universal CAR T cell therapy that acts independently of tumor-expressed antigens. (1/7) nature.com/articles/s4155…

@PhysInHistory The paradox of knowledge is eloquently expressed by Werner Heisenberg. As we discover and comprehend more, we also become aware of the immensity of what is still unknown. This is a frequent phenomenon in the journey of intellectual and scientific inquiry.

'The role of peripheral inflammatory insults in #AlzheimersDisease: a review and research roadmap' Keenan Walker @NIHAging... @HenekaMichael @BettcherNeuro #neuroinflammation bit.ly/3OSafGP

Online Now: Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity dlvr.it/Sph47f

The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci | Nature Computational Science nature.com/articles/s4358… #Bioinformatics

“Cytoelectric Coupling: Electric fields sculpt neural activity and “tune” the brain’s infrastructure” by Earl K. Miller et al. Progress in Neurobiology linkinghub.elsevier.com/retrieve/pii/S… 3/3

Cytoelectric Coupling: Electrical Fields Fine-Tune Brain Functioning Scientists present a hypothesis dubbed “Cytoelectric Coupling” suggesting electrical fields within the brain can manipulate neuronal sub-cellular components, optimizing network stability and efficiency. They propose these fields allow neurons to tune the information-processing network down to the molecular level. neurosciencenews.com/cytoelectric-c… 2/3

Unveiling 'Cytoelectric Coupling': A pioneering new hypothesis. The theory suggests the brain's electrical fields fine-tune its neural network efficiency. This concept is poised to revolutionize our understanding of the brain. #neuroscience 1/3

New preprint from the Cohen lab! Led by @iawindham, we found that astrocyte #APOE can traffic to #LipidDroplets, where it modulates LD composition and size: biorxiv.org/content/10.110… 1/12