Ceron Lab

🎉 Happy to share this review on such a relevant topic. 🤗Thanks to @JHmeljak for being a great and very helpful editor and @dmm_journal @Co_Biologists for their fantastic editorial process. 🧵👇🏼 Caenorhabditis elegans for research on cancer hallmarks journals.biologists.com/dmm/article/16…

Just published @ScienceMagazine Impressively broad range of life science research getting done autonomously with agentic AI to accelerate discovery science.org/doi/10.1126/sc…

@CSHANews @cshlcourses @gusaneros1 First week program👇

@CSHANews @cshlcourses @gusaneros1 Upcoming talks👇

Kick off for the first #celegans course at @CSHANews Suzhou, China. First talk about @cshlcourses by Maoyen Chin, CSHA director. Honored of being part of the team teaching in this course.

🏳️‍🌈Una bandera que reflejamos en cada laboratorio, en cada proyecto y en cada persona… ¡𝘆 𝗰𝗼𝗻 𝗺𝘂𝗰𝗵𝗼 𝗼𝗿𝗴𝘂𝗹𝗹𝗼! En el @IBV_CSIC trabajamos cada día por una ciencia diversa, inclusiva y libre💙 #IBVCSIC #Orgullo2026 #CienciaInclusiva

Meritocracia 🙏

This work is the result of a grant from @PpccSalud with the fantastic collaboration of teams led by @nstroustrup1 at @CRGenomica, Rafael Pulido at @biocrucesHRI, @Olmedo_lab at @unisevilla, Victor J. Cid at @unicomplutense and @MfPez at @IBMB_CSIC @gusaneros1

(3/4) 🪢 The functional impact of secondary mutations on PTEN variant outcomes (4/4) 👩 🧔‍♂️ 👱‍♀️ 🧑‍🦰 Inter-individual variability among isogenic animals with identical mutational landscapes, studied using single-worm RNA-seq

🔥New Preprint from our lab @idibell_cat @IBV_CSIC 📢In vivo functional classification of PTEN variants reveals context-dependent oncogenicity and interindividual variability biorxiv.org/content/10.648…

Nice overview of one of the most amazing animals on Earth! @gusaneros1 @annajuanroch @AMV_REDOX @raticosde100cia @IISLaFe From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism | PNAS pnas.org/doi/10.1073/pn…

Time to get ready for the Spanish Worm Meeting!! swm2026.com

El pasado lunes recibimos a Gary Ruvkun, Premio Nobel de Medicina 2024, invitado por @PremiosReiJaume en el @IBV_CSIC Conoció a personal, IPs y estudiantes, compartiendo experiencias y consejos científicos. ¡Gracias a todos los participantes! 💙 #IBVCSIC #Ciencia #Nobel

We are geting closer to the deadline!! swm2026.com Register yourself, guys! Worms are one of the coolest creatures on Earth @ehuntingtones @AsociacionAVAEH @FEDER_ONG @LluisMontoliu

Come on guys and girls! We're getting closer to the deadline for the one and only, awesome, incredible, and amazing X Spanish Worm Meeting in the lovely city of Valencia! swm2026.com

Pues así sigue el asunto. Proyecto de tecnologías #CRISPR parado 4 meses porque van muy liados. Esta es la triste realidad @DianaMorantR . La burocracia son plomos atados al cuerpo que nos dificultan mucho producir y competir, aunque sea con mucho menos presupuesto. Agotador 🥵

Solicitado a principio de Febrero a la @AgEInves el cambio de los fondos de un proyecto del @CienciaGob de un centro a otro por mudanza del laboratorio, y aún estamos esperando contestación. 4 meses con el proyecto parado por una burocracia y administración que no se entiende.

🧬 Compact CRISPR nucleases are small — but often slow to activate. A new strategy just fixed that. New preprint from Liu Junjie lab (Tsinghua): fusing ATPase DnaA to PlmCas12e (CasX) via a rigid N-terminal linker overcomes the conformational activation barrier. ⚡ 1.34× average editing boost across 7 endogenous loci in HEK293T 📈 More effective genome targets detected by GenomePAM/GUIDE-seq 🔬 MD simulation: single free-energy basin vs. rugged landscape in WT ❌ ATP hydrolysis mutant: activity drops below wild-type — mechanism confirmed Liu lab, Tsinghua | Preprint doi.org/10.65215/LTSpr… #CRISPR #Cas12e #CasX #ProteinEngineering #GeneEditing

📢 ¡𝗢𝗽𝗼𝗿𝘁𝘂𝗻𝗶𝗱𝗮𝗱 𝗽𝗿𝗼𝗳𝗲𝘀𝗶𝗼𝗻𝗮𝗹 𝗲𝗻 𝗜𝗕𝗩-𝗖𝗦𝗜𝗖! Vacante para Investigador Distinguido en inmunología, identidad celular y biología computacional con IA. 🔒Posición permanente y start-up package. 👉Más Info en: call.valer-f.es #ibvcsic

🧬 CRISPR evolution — directly inside human cells — for the first time. PNAS: CRISPR-MACE uses adenovirus replication to continuously mutate, select, and amplify Cas9 variants in human cells, bypassing bacterial evolution limitations. Key results: 🔑 "Gatekeeper" G12D mutation: 3× higher DNA affinity 💪 DVKIH 5-mutant variant: ~1000× anti-CRISPR resistance ✅ Validated in CASFISH imaging — brighter, stronger signal Shoulders & Choudhary labs, Broad Institute | PNAS doi.org/10.1073/pnas.2… #CRISPR #DirectedEvolution #Cas9 #GeneTherapy #Broadinstitute

@CeronLab @AgEInves @CienciaGob La burocracia es una lacra en todos los aspectos. Pero en el campo de la ciencia, va a acabar con ella...