Andy Chan

We are excited to share our latest work, in which we used human PSCs to build human “biological pacemaker” organoids that model the structure and function of the sinoatrial node. This provides a new platform to study pacemaker development, disease mechanisms and drug testing.

The EMBO Regeneration Meeting is coming up this September! Don't miss the upcoming registration deadline: May 20. Program and registration: meetings.embo.org/event/26-tissu…. #EMBORegeneration2026.

Our study on rare immune cell networks in liver cholangitis is now online! Using single-cell and spatial omics to investigate portal immune cell dynamics, we discovered a triad of cholangiocytes, dendritic cells and gdT cells regulating disease response. rdcu.be/fc60M

Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms hubs.li/Q049ypY80 Article highlight from Cell Stem Cell @bme_uoft

Happy 30th birthday, Pokémon! Since 1996, the Japanese media sensation has inspired generations of researchers in fields as diverse as evolution, biodiversity and research integrity. go.nature.com/4tZOzKY

embl.org/about/info/cou… The 2nd edition of the upcoming „The NewCardioBiology“, where cardioscientists meet vascular biologists and engineers, has still a limited number of poster presentation positions available. Submit and register until Jan 5th. Please, repost this!

Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages dlvr.it/TPdgPM

🦣🧬🦣 🤯💥 We are pleased to share our new paper about ancient RNA expression profiles from the Woolly Mammoth, now published in Cell @CellPressNews cell.com/cell/fulltext/… If you want to know more, read the 🧵 below: #mammoth #RNA #DNA #Pleistocene

@jmartinlab @MiaoCui_713 Excited to know about this!!

First Clinical Investigation of a Gene Therapy (YAP101) to Induce Cardiac Regeneration to Treat Heart Failure Passes Initial Safety Hurdle - businesswire.com/news/home/2025…

Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis. doi.org/10.1038/s44161… rdcu.be/ePzs6

@MiaoCui_713 Thanks Miao!

@ChanAndyson Congratulations Andy!!

Excited to share our new paper “Spatiotemporal dynamics of the cardioimmune niche during lesion repair” just published in Nature Cardiovascular Research! nature.com/articles/s4416…

We also built an Shinyapp interface that allows everyone to access our single cell and spatial datasets easily: wuesi.medizin.uni-wuerzburg.de/cardiac_spatio… We envision our datasets will serve as a resource will provide insights for the cardiac and regeneration/fibrosis fields in the future!

Huge thanks to my PI Dominic @dominic_grun , my friends/colleagues in the lab, and all my collaborators who shared their efforts and dedication over these years!! This 5 year-journey wouldn’t have been successful without you all! 🙏

Online Now! Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling dlvr.it/TNvxMR #stemcells

@CanAztekin Congratulations!!

🥳Thrilled to share that our lab has been awarded an ERC StGrant for our project SigReg: Signal to Regeneration! How can we unlock limb regeneration in adult mammals? It’s time to apply what we learned from 🐸 ➡️ 🐭 bio.mpg.de/480424/news_pu…

Potato evolved from tomato 9 million years ago. cell.com/cell/fulltext/… @NHM_London Sandra Knapp @UBC Loren H. Rieseberg @SCUCN Jianquan Liu #CAAS Sanwen Huang @cellcellpress

New preprint from the lab! Using multiplexed spatial analysis and single-cell multiomics, we resolved the portal liver immune niche and identified crosstalk between cholangiocytes, dendritic cells and gdT cells controlling fibrosis in a cholangitis model. biorxiv.org/content/10.110…

This is effectively a cure for type 1 diabetes. Autologous, (chemically) reprogrammed iPSCs were engineered from a patient's fat cells and injected back into her stomach. After ~2.5 months, she no longer needed insulin and now enjoys ice cream + candy like a normal person.

BREAKING: MIT just completed the first brain scan study of ChatGPT users & the results are terrifying. Turns out, AI isn't making us more productive. It's making us cognitively bankrupt. Here's what 4 months of data revealed: (hint: we've been measuring productivity all wrong)