CoinControversy

Elite supplements that few talk about: - ornithine AKG - DMAE - PEA - PQQ - Ergothioneine - Royal Jelly

@babysolo_ The good news is you just bought a south east Asian lady a new pair of boots.

@Zedzies pmc.ncbi.nlm.nih.gov/articles/PMC77…

Currently megadosing beta alanine high carnosine levels = reduced AGEs, younger muscles, and more maturitas.org/article/S0378-…

Photosynthesis happens in mammalian EYES....??/ cell.com/cell/fulltext/…

@tedcruz I wish you weren’t Israel first.

@fedichev this is nonsense lmao

Most of human aging is thermodynamically irreversible. While it's a much disliked phrase. However, I think it's one of the most important and actionable statements in the field, because it means the goal is not rejuvenation. The goal is to stop the clock. And now let me tell you how. At @hacking_aging, we feed medical histories across tens of millions of people into physics-based machine learning models, which: • Use patients medical histories to predict how a person's health evolves over the full arc of their life • Pull aging out as a distinct process from specific disease trajectories This happens not because we told the models to, but because the signal is there in the data. Through this analysis, we identify genetic targets that control the rate of aging itself—not a particular disease predisposition or progression, but the underlying aging process closely related to configurational entropy of the aging organism. These genetic factors do not tell stories about treating particular diseases; they're about shifting the fundamental rate at which aging occurs. In 2021 we were the first estimate the maximum human lifespan from clinical data. What's gets measured - get optimized. Today, that estimate is approximately 120 years. This is how aging biology can be framed as a data problem, and the data analysis can reveal what no amount of experimentation alone cannot. Think of this post as a imminent new preprint announcement - please like, share and follow to know more, check and subscribe to my Substack using the link in the first comment.

@Mandrik no, rand paul is legit in the house, yes

RIP Massie, the last Ron Paul Republican in Congress.

@Lemiwnks @lady_smith94 @TrackAIPAC 🇮🇱 bot

@lady_smith94 @TrackAIPAC LMAO!! Your tears. They’re so salty. So delicious.

Rep. Thomas Massie has been unseated by AIPAC’s Ed Gallrein in what is now the most expensive House primary in U.S. history. #KY04

@GettingWell4 @BiluHuang @siimland where are you getting 10mg and 5mg? i was under the impression that the amounts in humans were in the grams

Maybe, if ITP results weren't twisted. The first study flubbed the 4000 ppb intended astaxanthin dose to a human equivalent 10 mg (1840 ppb x .081 x 70 kg). The most recent astaxanthin study halved that to a human equivalent 5 mg, which isn't found anywhere in the commercial marketplace or recent human experiments. Their paper didn't acknowledge the first study's mistake because it's all government funded. And the most recent paper studiously avoided previous and current mistakes, explaining away their Jackson lab female control group age as an anomaly. All this astaxanthin prevarication showed that the researchers forgot about the primary purpose of rodent studies, to benefit humans.

Russian scientists are trying to develop an anti-aging gene therapy. The pathway is supposed to target RAGE or the receptor for advanced glycation end-products (AGEs). While there's no evidence that it would extend lifespan, it highlights the emerging Cold War in life extension research. Full video: youtu.be/RzhRvfL0uzE

@BiluHuang @siimland Meclizine increased lifespan on the first dose schedule, yet you conveniently left that part out pubmed.ncbi.nlm.nih.gov/38041783/

The accumulation of advanced glycation end-products (AGEs) is merely a downstream consequence of aging rather than a driving factor of aging. The senescence-associated secretory phenotype (SASP) secreted by senescent cells and the inflammatory microenvironment are believed to induce senescence in adjacent young cells. Nevertheless, nicotinamide riboside (NR), which elevates NAD⁺ levels, reduces the release of inflammatory factors by 52.6% [195]. Macrophage migration inhibitory factor antagonist (MIF098) and the antihistamine meclizine, both capable of alleviating chronic inflammation in vivo, as well as astaxanthin with antioxidant, anti-inflammatory and DNA damage-mitigating properties, were assessed via the Interventions Testing Program (ITP). Results revealed that NR shortened the lifespan of male mice by 3%. Neither MIF098 nor meclizine could extend mouse lifespan. In female mice, astaxanthin was associated with significant lifespan reduction [16,69]. These findings directly demonstrate that an inflammatory cellular microenvironment does not promote cellular senescence.

@siimland except basics won't extend lifespan :(

The “anti-aging stack” most people miss: - getting lean (<12% men; <25% women) - afternoon 10 min nap - not getting sunburnt - speed and sprint training - lifestyle enrichment - drinking 2-3 liters of liquid per day - sleeping 7-8 hours - strength training 2-3x a week - low-intensity aerobic exercise - getting >3,500 mg of dietary potassium a day

@StjepanZRPavic @vladileshko @aubreydegrey @VitalistBay it proves that it works via evolutionarily conserved mechanisms rodents are actually quite similar to us and other primates

@CoinControversy @vladileshko @aubreydegrey @VitalistBay Yes, and differnent effectiveness,on a worm compared to a rodent vs a primate, it's not linear across species.. same with just focusing on mammals, higher metabolic rate ones do have naturally shorter lifespan and have more life percentage extension using rapamycin.

Aubrey: The idea behind mice life extension is not necessarily translating to humans, BUT showcasing that radical life extension of mammals is possible in principle.

@StjepanZRPavic @vladileshko @aubreydegrey @VitalistBay rapa works in: worms flies rodents primates canines

@vladileshko @aubreydegrey @VitalistBay guy is just a preacher, what did he even do. Even drunks in my neighborhood have some deep shit to say..So what..Also he doesn't understand biology, especially evolution. Showing something on mice doesn't mean now we can extend to mammals, mammals are much more diverse group ffs

@PaxAeterna @dotkrueger bruh he's a literal pawn of israel how do you not see that?!?

@dotkrueger Derangement by a mile. By wanting Trump to win at least that’s pro America and helps people on the whole. The hate Trump for everything is just insanity. He at least wants America to win. He’s a terrible sinner for sure. So am I. But I cheer his success.

What's worse?

@vladileshko @JosephPKennedy3 @VitalistBay @bryan_johnson yes he is both would look older with their natural hair color that is, if it's his real hair

@CoinControversy @JosephPKennedy3 @VitalistBay @bryan_johnson is also dying his hair.

Greg Fahy is based! The guy is 76!! and still optimizing the hell out of cryoprotectants. I feel him cause gerontology and treatments vs aging are not progressing fast enough. We need cryo as backup. Also, Greg pioneered TRIIM - the first ever protocol to rejuvenate a human on organ level, in this case the thymus - a key part of the immune system. Thymus gets wrecked already by your 50s, and I don’t understand why we don’t have hundreds of alternative thymus protocols getting developed by other groups. As a true biohacker, Greg first tried it on himself, then proceeded to human trials. A very efficient way to do medical science. We need to solve aging to keep people like Greg going for the benefit of all of us.

@vladileshko @JosephPKennedy3 @VitalistBay yeah but he's dying his hair

@JosephPKennedy3 @VitalistBay He's in top shape

👀 sciencedirect.com/science/articl…

@PGC1a_RB veryy good for skin health

So for those who've increased glycine intake lately, what's been noticed, if anything

@HodlMagoo @mithcoons or was blackmailed over the epstein cases

@mithcoons Well Trump did kind of cause the biggest energy shortage since the 70’s because he believed BeBe

We missed earnings due to.. 𝙻̶𝚘̶𝚌̶𝚔̶𝚍̶𝚘̶𝚠̶𝚗̶𝚜̶ 𝚂̶𝚞̶𝚙̶𝚙̶𝚕̶𝚢̶ ̶𝚌̶𝚑̶𝚊̶𝚒̶𝚗̶𝚜̶ 𝙸̶𝚗̶𝚏̶𝚕̶𝚊̶𝚝̶𝚒̶𝚘̶𝚗̶ 𝚃̶𝚊̶𝚛̶𝚒̶𝚏̶𝚏̶𝚜̶ 𝙰̶𝙸̶ Middle East