David Exposito-Alonso

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the cerebral #cortex. This is the story @CellCellPress cell.com/cell/fulltext/… ⬇︎ thread @dev_neuro @MRC_CNDD @KingsIoPPN @KingsCollegeLon @wellcometrust

1/12. How do cortical interneurons select specific pyramidal cells during development? Julie Jezequel in @Rico_lab has identified specific cellular and molecular codes that interneurons use to target pyramidal cell types @NatureComms @dev_neuro @MRC_CNDD @KingsIoPPN

Today in @Nature, we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas. We built an interactive browser to explore the spatial data: walshlab.org/research/corte… Paper link below👇

1/10 Our latest research, led by @MartijnSelten, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @Nature nature.com/articles/s4158… 🧵⬇︎ @dev_neuro @MRC_CNDD @KingsIoPPN @ERC_Research @RosetreesT

Association cortices were shown to stain poorly for PV in many species, and neuroanatomists have used this to delineate these areas. Only recently this has been investigated in the context of inhibitory cell types: pubmed.ncbi.nlm.nih.gov/26441554/ pubmed.ncbi.nlm.nih.gov/28985566/

Just out! Thanks to @jhtsong, Ryan Doan, @OldManTae and to the @AllenFrontiers Center for Human Brain Evolution! Remarkable that HARs carry as much or more recessive genetic risk for ASD as more highly conserved regulatory elements! @HHMINEWS @BCHNeuroRes @harvardmed

Excited to publish a broad set of enhancers to target interneuron types in the brain, along with a broad set of collaborators. This is part of the BI armamentarium, which together will help revolutionize the targeting and understanding of brain circuits. biorxiv.org/content/10.110…

I am delighted and grateful to @wellcometrust for granting us a Wellcome Discovery Award, which will enable us to explore the emergence of human cortical circuits over the next eight years @CDN, @CNDD, #synapses, #interneurons, #circuits, #development

Our exploration of the mechanism regulating the terminal differentiation of PV interneurons in the mouse cortex. Exciting new work from Monika Moissidis and colleagues @dev_neuro @MRC_CNDD

Our work about contrasting patterns of somatic mutation accumulation between oligodendrocytes and neurons in the aging human brain, is now online in @CellCellPress! Huge thanks to @sarabiz86 @JoeLuquette @peter_j_park @ChrisAWalsh1. See tweetorial (1/10). tinyurl.com/4u9fj84r

A review article with @studerl on "Epigenetic control and manipulation of neuronal maturation timing" and models of potential interactions between molecular pathways controlling developmental rates. sciencedirect.com/science/articl…

Excited to share that our paper on an epigenetic barrier setting timing of maturation in human neurons is finally out @Nature! go.nature.com/48dhO0V.

How do neurons integrate excitatory and inhibitory inputs in a developing circuitry with remarkable neuronal diversity? If you are interested, do not miss our latest paper preprint in BioRxiv by my exceptional postdoc Tim Kroon in @Rico Lab, #synapses, #interneurons, #cortex.

Please check out our study on VIP interneurons & attention, now published in @NeuroCellPress. Particularly proud that this first paper from the lab is essentially a negative result! cell.com/neuron/fulltex… Led by the amazing @DMyersJoseph with @k47h4 @marianf_otero & @ClopathLab

Our biggest EEG biomarker study to date just got published in @NatMentHealth Alpha peak frequency-based Brainmarker-I as a method to stratify to pharmacotherapy and brain stimulation treatments in depression Here we show that Brainmarker-I can help stratify between various antidepressants treatments from psychotherapy, sertraline to TMS protocols, ECT, Ketamine etc. Stratification potential validated for most treatments using blinded out-of-sample validation. Conclusion: We hereby present a clinically actionable transdiagnostic treatment stratification EEG biomarker that can successfully assign patient subgroups to various ADHD and MDD treatments, and is ready to be implemented in clinical practice. nature.com/articles/s4422… Huge effort by first author @HVoetterl Thanks to the whole team @Sack_BSClab @DeepPsy1 Sven Stuiver, Renee Rouwhorst, @AmouriePrentice @DiegoPizzagalli @NikitaVinne Jeroen van Waarde, Martin Brunovsky, Iris van Oostrom, Ben Reitsma, Johan Fekkes & @hanvdij

@FdeCastroS @ScienceMagazine @AllenInstitute @jhtsong @ChrisAWalsh1 Thanks!

@DExpositoAlonso @ScienceMagazine @AllenInstitute @jhtsong @ChrisAWalsh1 Excellent...! Congrats & thanks...!

1/4 Has #brain gene expression evolved differently in humans? See our latest paper @ScienceMagazine in collaboration with Trygve, Nik, and Rebecca @AllenInstitute and @jhtsong (also in @ChrisAWalsh1 lab) using #transcriptomics of #neocortex in primates! science.org/doi/10.1126/sc…

4/4 Our study identifies genes and non-coding regions that may be involved in human-specialized function of the #CerebralCortex. @AllenInstitute @harvardmed @BostonChildrens Check out all the awesome papers @ScienceMagazine part of the #BICCN consortium! science.org/toc/science/38…

3/4 There are hundreds of human-specific differentially expressed genes (DEGs)! A significant fraction of them is associated with specific synaptic signaling pathways and are found near regions of the genome with human-accelerated mutations and deletions (HARs and hCONDELs).