@mudscryer Don't you have someone to look through it for you? Name rhymes with Maude
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Isaac Yonemoto is cooking
18.4K posts
Isaac Yonemoto is cooking
@DNAutics
Prompt charmer, AI pharma founder, former AI infra plumber, former ivory tower biochemist video: https://t.co/5BsV4r5TsH code: https://t.co/d0RaSeegaG
Katılım Ağustos 2010
254 Takip Edilen3.1K Takipçiler
Can someone study this and then tell me what to post to become wealthy and successful and partnered? I know other people have done it through this app so it’s not much of a stretch.
Elon Musk@elonmusk
The latest 𝕏 algorithm has been published to GitHub github.com/xai-org/x-algo…
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@josevalim So I have a built from scratch custom diffusion transformer (for biosequences) that I built and trained in pytorch in february. Claude oneshotted the conversion to Nx.
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I'd say the fact you can quickly explore alternatives to foundational choices, such as the programming language or framework you chose, in days rather than weeks/months is the most interesting aspect of it indeed. Time will tell if moving forward was the right call.
I am also very curious about how generally applicable this is and what made it possible. An extensive test suite is probably a must and it seems they attempted a "one-to-one port" rather than a rewrite. But Bun is also about JavaScript, something the models are quite familiar with and there are several reference implementations. Would this have worked on closed-source projects with internal documentation only? What other factors played a role here?
Mitchell Hashimoto@mitchellh
It isn't unexpected that the focus of the Bun Rust rewrite is on the anti-Zig side more than anything, since the internet loves to hate. What is unexpected and unfortunate is that leadership within Bun hasn't tried to steer the conversation away from that at all. There are so many positive and interesting takeaways from this and I'm not really seeing any of them pushed as the primary message. A positive thing that hasn't been talked about at all is how far Bun came thanks to Zig. And even if you dump it now, its meaningful for how good Zig was to even build a product to this point and impact by any metric. I would've loved to see anyone in leadership say this. On the interesting side is how fungible programming languages are nowadays. Programming languages used to be LOCK IN, and they're increasingly not so. You think the Bun rewrite in Rust is good for Rust? Bun has shown they can be in probably any language they want in roughly a week or two. Rust is expendable. Its useful until its not then it can be thrown out. That's interesting! There's been a lot of talk about memory safety and no doubt Rust provides more guarantees than Zig. But I'd love to see a better analysis of why Bun in particular suffered so much rather than take the language-blame path. How could engineering as a practice been more rigorous to prevent this? What were the largest sources of crashes other programs should watch out for? How does Rust prevent them? How could Zig theoretically prevent them? That's interesting. I know the official blog post hasn't come out yet from Bun. But they're smart enough to know that that PR would stir up controversy the moment it opened, or they should've been. And plenty in the company have been tweeting and writing about it. Its somewhat telling to me in various dimensions what they chose to talk about first. I tend to think I'm pretty good at corporate PR/comms (especially when it comes to developer audiences) and I think appealing to the negative is never the right long term strategy; it does work to get short term eyes though.
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@basichumanstf @Casebradford Angels are boring anyways go metal 🤘
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Every time a soft feminine women starts taking fitness seriously an angel loses its wings
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@krishna180406 @croloris @merlinaudio_ Yes IIUC it's c and the contracts are verified by analyzing the arm64 assembly code.
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My take on the bun stuff #c_kvngy9" target="_blank" rel="nofollow noopener">lobste.rs/s/lapqbz/bun_s…
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@croloris @merlinaudio_ I should point out that an ir-based analysis is similar to what sel4 does and IIUC sel4 is provably memory safe. Clr is just heuristic but in principle one could do a proof-based checker instead. That is however above my capability.
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for sure there's interest in eventually enabling easy IR analysis by other tools, but afaik the current perspective on this from the core team is that it's not likely that it will be something as fool-proof as the borrowchecker, unless we end up discovering something big that somehow Rust has missed till today.
I believe the project you're referring to is github.com/ityonemo/clr. I believe Isaac is more optimistic about what it can be done, but I guess the burden of proof is on him, at least for now
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@croloris @aa1337 @merlinaudio_ Yep. I'm happy to have my bots keep track of what's new :). Glad to hear there will eventually be a path forward.
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@aa1337 @merlinaudio_ Eventually, now it's too early, Zig IRs keep changing
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@SergioGMN @garybernhardt Did you test it? Is there safe navigation through the null?
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@garybernhardt So I've been a backend wev dev for a bit over 3 years and I had never tried to invert a binary tree because it's something I never needed to do and I hadn't even thought about it
After reading this tweet I tried it and solved it within three minutes lmao what's the debate??
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Every professional programmer can invert a binary tree. Not from memory; you don't need to memorize anything. You can do it from a short description of the problem. It's one step above fizzbuzz. Anyone who rails against this doesn't realize how trivial "invert a binary tree" is.
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@jarredsumner @simonklee Coulda put a few hundred thousand tokens on my borrow checker for zig ;)
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@simonklee > this is bad news
Most of the feedback from OpenCode users to Bun has been crash reports. Many of these crash reports would not have happened with a borrow checker and lifetimes and automatic cleanup Rust provides.
Please file issues if you run into any and we will fix.
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Say what you want, but for people building products on Bun, this is bad news for the foreseeable future.
github.com/oven-sh/bun/pu…
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@soychotic I can't stop thinking about the unregulated plasticizer residue
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I don’t know why but nothing makes my guts churn more than seeing adults opening seemingly useless cheaply made wares and then screaming into a camera . How the hell did you make it this far into your existence . Are you proud of what you are
Funnyandfabs@funnyandfabss
Glitter dumpling squishy unboxing 😂😭
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@operationdanish #1 and #2 are reasonably doable and I think I know how I'd do it (but not clinically). #3 and #4 are absolutely spot on.
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I hope they know something the rest of the world doesn’t… but at its face, it makes zero sense. Simple breakdown:
1. Nuclear delivery of a large protein (systemically, to every cancer cell) is an unsolved (and likely impossible) barrier… they need a “perfect” vector that doesn’t exist.
2. “Scanning the genome”… for one exact sequence in a living nucleus is biologically implausible at scale… “DNA sensing protein” is total mumbo jumbo
3. Perfect specificity and “healthy neighbors untouched” is just marketing BS… that’s not how real tumors work (there isn’t one defined clean DNA sequence across the entire tumor)
4. “Cure all cancers” is just an insane thing to say out loud. Super suss.
The core idea, i.e. sequence-specific cell elimination, is grounded in real research. But packaging it as ONE off-the-shelf protein that reads DNA like software, cures all cancers, and collapses pharma timelines is nonsensical.
Y Combinator@ycombinator
FinalDose is building the first programmable drug platform - a single smart drug molecule that finds diseased cells by their DNA and destroys them. They're starting with all cancers. Congrats on the launch, @Jeffliu6068Liu, @sklin_lite, and @liyaohuang2! ycombinator.com/launches/QKj-f…
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Isaac Yonemoto is cooking retweetledi
Swival audit of Tigerbeetle. Zero high-severity findings. Zero. #tigerbeetle-audit-findings" target="_blank" rel="nofollow noopener">github.com/Swival/securit…
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@lpachter @_AndrewLeduc In biology we have to pay for expensive AI and also growth medium, pipette tips, electricity for -80 freezers, lambo, etc.
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@_AndrewLeduc Mathematicians are facing a future where access to expensive AI is essential for research and it is not at all obvious where they might secure funding.
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Mathematicians: AI => what is math?
Biologists: AI => increase grant funding probability?
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@cremieuxrecueil Don't leave it to chance, request the groping each time. Bonus points if you make the TSA agent clarify what he means by "resistance". Every. Time.
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I was very optimistic saying this and then I started Qwen 9B and OMG the output of that model (just to be fair - it's Q3_K_S) is just something else - if that would be a SOTA model nobody would bother with AI. The amount of hallucination is just drastic (e.g. unless in header)😬
Kamil Skowron@kamilskowron
Credence 0.4.5 is out🥳 Already two people have contributed to it😍 Now that it reached the point where Credence handles the initial problems generated by Qwen, I think I’ll move on to a slightly smaller (and FASTER) model that produces even more weirdness for Credence to fix 💪
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@techexplain1 Doesn't RF have enough energy to promote an electron over the conduction bandgap in the DNA conduction channel?
nature.com/articles/18855
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People are switching to wired headphones because they think bluetooth cooks your brain.
But are the RF waves transmitted from AirPods really dangerous or is it just an internet myth?
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@demystifysci I didn't have a clean lab :(. Haha I guess I do now!
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look I love my bluetooth headphones but the idea that it's beyond the pale that non-ionizing radiation might have biological effects is a little half-baked
tech.explain@techexplain1
People are switching to wired headphones because they think bluetooth cooks your brain. But are the RF waves transmitted from AirPods really dangerous or is it just an internet myth?
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Never trust (or listen) to anyone that gives advice in absolutes..
Not in this era. Not at this time. Everything is changing and rearranging so freaking quickly.
Sure, some things are evergreen - focus on retention, run a good business and don’t commit fraud. But a lot of the old priors are turning out to be garbage aka don’t boil the ocean, do just one thing, figure out your wedge.
PS: I’m sure someone will dig up one of my tweets where I have done this and fine, I was just wrong
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Meditation on “good” and “enough” and “good enough” and “not good enough”
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