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David Sinclair
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David Sinclair
@davidasinclair
Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan
Harvard Katılım Mart 2012
1.1K Takip Edilen585.5K Takipçiler
David Sinclair retweetledi
The cholesterol wars are over.
LDL won.
New guidelines. Four landmark trials. An oral PCSK9 inhibitor that matches injectables. And data proving we should be treating patients we currently aren't.
Here's everything clinicians need to know. 🧵
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David Sinclair retweetledi
🤣 That’s why we make sure the reprogramming technologies we develop can’t take cells back in epigenetic age more than ~75%
RippleMuse@RippleMuse1111
@davidasinclair As long as I don’t have to do puberty and middle school again, I’m in.
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Sid's journey (@sytses) in treating osteosarcoma is a fascinating foray into becoming the CEO of your own healthcare. We pressure tested our platform, LigandAI, on his personalized data. Could we use LigandForge and LigandAI to design peptides to target all of the relevant cells?
Elad Gil@eladgil
Impressive on so many levels ❤️ sytse.com/cancer/
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@davidasinclair Peter's work highlights epigenetic regulation of aging, but integrating signaling pathways like sirtuins and NAD+ levels can deepen understanding of age-related epigenetic shifts.
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Peter does great work understanding epigenetic changes during aging 👏
Peter Adams🇪🇺🇺🇳@AdamsBioAging
This is an excellent conceptualisation of epigenetics of aging. Takes a complicated topic and distills it down. Good to see histone H3.3 featured. For our latest contribution on histone H3.3 and aging see here biorxiv.org/content/10.648… @NatureAging
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David Sinclair retweetledi
A Harvard professor who's studied aging for 30 years says one of the most powerful longevity tools on Earth is free.
Fasting.
David Sinclair explained what happens at the cellular level when you stop eating food for long periods of time:
Your body has proteins called sirtuins. They're the conductors of your cellular orchestra - telling each gene when to turn on and off, keeping every cell's identity intact.
But sirtuins need fuel called NAD to function. By age 50, your NAD levels drop by HALF. Your conductors are running on empty. Your cells start losing their identity.
Fasting raises NAD back up. It reactivates the sirtuins and preserves the epigenome.
Sinclair mentions it's only useful if you're already meeting nutrient and micronutrient intake as well.
He himself skips breakfast daily and tries to go until late afternoon before eating.
Once a month, he fasts for 3 full days because deep cellular recycling - called chaperone-mediated autophagy - only kicks in after about 2 and a half to 3 days.
He called three meals a day "craziness" and said the idea that breakfast is the most important meal of the day was "marketing from the early 20th century" by cereal companies.
Fasting is just one of the strategies he uses for optimal health.
— @davidasinclair
John Cumbers@johncumbers
David Sinclair is on a mission to turn age reversal into a $100 pill. Right now, his gene therapy costs roughly $10 million to manufacture and requires a direct injection into whichever organ you're targeting. That's not going to work for 8 billion people. So Sinclair's team made a breakthrough. They found that the three age-reversal genes aren't the only path to resetting cells. They discovered CHEMICALS that do the same thing. In mice, they can now give an animal a liquid - not genes, not injections, a drink - and rejuvenate tissues in 4 weeks. Sinclair says it's now normal for his students to casually report: "We just rejuvenated the ear. We just rejuvenated the skin. We just cured ALS (motoneuron disease) in these animals." He calls his lab "Willy Wonka's chocolate factory" because the discoveries blow him away every week. But he wants one molecule that does everything. So they used AI to screen 8 BILLION candidates. They're now down to three molecules that work. And they're using AI to try to combine all three into one. The gene therapy could cost over $100,000 per treatment. Sinclair's goal: "What if it could be $100 instead? That's what I'm working for. I want to democratize this technology so anyone even in Kenya can take these medicines." They should know within a year or two if the molecules work in mice. The gene therapy is the proof of concept. The pill is the endgame. David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists who matter in this space will be in the room. Link for tickets below. — @davidasinclair
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In humans, calorie restriction slows biological aging pace by ~2–3% over 2 years (CALERIE trial)
nature.com/articles/s4358…
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The biggest mistake is thinking decline is inevitable
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@agingdoc1 Thanks for posting 🙏 We lost 3 of our team making that paper - Mike Bonkowski, Jay Mitchell and Norm Wolff. It means a lot to us when people appreciate the work
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Loss of epigenetic information as a cause of mammalian aging
“we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA methylation clock, which can be reversed by OSK-mediated rejuvenation…”
cell.com/cell/fulltext/…
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David Sinclair retweetledi
THIS IS WHY you need to take great care of yourself... to bridge to Longevity Escape Velocity. Healthspan extention is real. LEV by 2033!
Lifespan@JoinLifespan
Age reversal is natural
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David Sinclair retweetledi
BOOM! Eli Lilly just signed a $2.75 billion deal with Insilico Medicine.
This is actually huge for longevity. Let me explain why. 🧵
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Exactly why I started Lifespan.com - so everyone, including uncles & grandparents, can get evidence-based knowledge
Too many people are not getting the latest health information or completely wrong information from social and legacy media
Jeronimo@jeronimobiohack
Excellent work, David. Now what we need is to inform the general public—those who may not be in X, I mean our parents, uncles, and grandparents—that there are ways to improve their health, that they don't have to resign themselves to thinking that every ailment they have is due to old age and consider it irreparable. They need to learn that some diseases can be prevented and others can be improved simply with some good eating habits and increased physical activity.
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Grok is right
CRISPRKing@CRISPRKING
@grok the science of age reversal has been advancing for years what hasn't kept up is the infrastructure to connect the people doing the work ⠀ that's what sinclair is pointing at not another supplement brand not another podcast a coordination layer where researchers, clinicians, and patients share the same information in real time ⠀ "age reversal is natural" is a bold frame but it's backed by evidence most people haven't seen yamanaka factors reset epigenetic age in cells partial reprogramming reverses aging markers in live mice the body already contains the instructions to be younger it just lost the ability to read them clearly ⠀ the bottleneck was never the biology it was always the gap between discovery and application a paper gets published takes five years to reach clinical trials takes ten more to reach a patient by then the science has moved three generations ahead ⠀ if lifespan compresses that gap by connecting the right people at the right time it won't just accelerate longevity research it'll change who benefits from it and how soon ⠀ the future of aging isn't a single breakthrough it's a network that makes breakthroughs inevitable
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