David Penton

Congrats @bakhta_f for this amazing work that I have the pleasure to present today! Our new models of Primary Aldosteronism will be useful tools to better understand the disease and to test new therapeutic approaches in the future! @ENSAT_news @goharmonisation @AldolabZ

We are delighted to announce that it is now possible to assess the functional properties of neurons (IPSC-derived, primary, organoids) using HD-MEAs at the Electrophysiology Facility of UZH. Check out our summary of the services we can offer using this technique. The e-phac team

Hamburg news: Bridging patient observation to molecular understanding in our molecular disease board: Here revealing a multi-hit model for FSGS by Jan Czogalla @PuellesVictor and team. @HCKH_Hamburg @UKEHamburg @unihh kidney-international.org/article/S0085-…

These kind of measurements allow us to follow network dynamics of #iPSC-derived #neurons, #cardiomyocytes, #brain #organoids, primary neuronal cultures and more. Furthermore, the high-density of electrodes provide information about action potential propagation along neurites

First data from our HD-MEA setup at #EPHAC! Watch how primary cortical neurons (kindly provided by @SchrattL) fire synchronized bursts of action potentials as soon as at DIV9. Get in touch if you are interested in using this system with your cells. @mxwbio #neuroscience

@FBeuschlein Bravo Felix!

Greatest honor in my career! Hope to spend the money in Stockholm and Boston to provide drinks!

@PAWellingMD @RickGrimmPhD Congrats Paul for this excellent work

Automated patch clamp was originally developed for the pharmaceutical industry, but Thompson et al. repurpose it to investigate functional properties of several sodium channel variants associated with neurodevelopmental disorders bit.ly/47xrSCz #SCN2A #epilepsy

Calcineurin regulates aldosterone production via dephosphorylation of NFATC4: buff.ly/3KaB6uu #Endocrinology #Metabolism

Out now: Calcineurin regulates aldosterone production via dephosphorylation of NFATc4 insight.jci.org/articles/view/… @DavidPentonR @UZH_en @UniBasel_en

#aldosterone #potassium #hyperkalemia #adrenalgland

@FBeuschlein Thanks @FBeuschlein. Also for your support in this journey

New mechanisms to regulate aldosterone production - great work by David Penton and associates! Calcineurin regulates aldosterone production via dephosphorylation of NFATc4 asci.altmetric.com/details/150023…

Why do hyperkalemic kidney transplant recipients on CNI show no aldosterone response -a question open since a 1983 Lancet paper-seems to have been mechanistically explained. Congrats, @DavidPentonR ! insight.jci.org/articles/view/… 1983 Lancet paper: thelancet.com/journals/lance…

@janczogalla Thanks Jan!

@PAWellingMD Thanks Paul!

Calcineurin inhibitors and hyperkalemia linkedin.com/posts/davidpen…

@rofe6065 @m_stowasser thanks Rob!

Super study David and team. Highly translational @m_stowasser

JASN is proud to announce that applications for the 2023–2025 Editorial Fellowship Program are now open! Early career researchers with interest in basic or clinical research are encouraged to apply. For more information, visit bit.ly/JASNEditorialF… #jnltrain

Impressive throughput from the automated patchclamp @NanionTech presented at #LS2AM23 @LS2_ICMT @LS2Switzerland And there is one just next door in Zurich! Contact the electrophysiology facility @e_phac from University of Zurich for more information.