DeRenzoLab

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So much fun to be part of the #ISPNO2024 immunotherapy debates with Elias Sayour, Frank Lin, @DeRenzoLab, & Dean Lee. See me here splitting up my talk by shamelessly plugging our open post doc position in the #VitanzaLab @seattlechildren

@JournalofExper1 @Ha_Won_Lee Great work out of @StJudeResearch, #osteosarcoma, #drugscreen, #CARTcell

New study!🏹 A high-content screen of FDA approved drugs to enhance #CART cell function: ingenol-3-angelate improves B7-H3-CAR T cell activity by upregulating B7-H3 on the target cell surface via PKCα activation For free⤵️ jeccr.biomedcentral.com/articles/10.11… #Tcell #Osteosarcoma

CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity aacrjournals.org/cancerrescommu…

CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity aacrjournals.org/cancerrescommu…

Sharing our method to washout DMSO prior to @intracranialCART infusion sciencedirect.com/science/articl…

Congratulations Dr. Beckett!!!!!!!!!! So well deserved.

Engineered CD47 protects T cells for enhanced antitumor immunity biorxiv.org/content/10.110… Exciting work out of the Mackall lab!

We’re excited to share St. Jude has been ranked again among the top 5 pediatric cancer hospitals in the US by @usnews. Learn more about this achievement. bit.ly/46dQj7r

Check out this very interesting work by @dalia_haydar, @GiedreKrenciute and colleagues to examine CAR T cells against brain tumors in the context of a fully immunocompetent environment. researchsquare.com/article/rs-297…

Excited to share this new work. Ha Won, Carla and team did an exceptional job to show these new findings.

A high-content screen identified ingenol-3-angelate as an enhancer of B7-H3-CAR T cell activity by increasing B7-H3 protein expression on the target cell surface via protein kinase C alpha activation biorxiv.org/content/10.110…

@biorxivpreprint Excited to share this new work. Ha Won and team did an exceptional job to show these new findings.

A high-content screen identified ingenol-3-angelate as an enhancer of B7-H3-CAR T cell activity by increasing B7-H3 protein expression on the target cell surface via protein kinase C alpha activation biorxiv.org/cgi/content/sh… #bioRxiv

Excited to share Peter Chockley's work on Synapse-tuned CARs out in Nature Biotech today @NatureBiotech @Kyttaro_Therapy @StJudeResearch Synapse-tuned CARs enhance immune cell anti-tumor activity | Nature Biotechnology nature.com/articles/s4158…

New #JITC article: CD47 expression is critical for CAR T-cell survival in vivo bit.ly/42exzTt @itsalexbeckett

Fascinating work on this important aspect of CAR T cell biology.