Devin Haddad, MD

@IrmaMDv ahajournals.org/doi/10.1161/JA…

A 26-year-old woman, physically active and asymptomatic, presents for a routine check-up. You smile 😊 —until you order an ECG. Suddenly, the smile vanishes. 😧 Should you be concerned— or is there no cause for worry?

@bigfatsurprise @KieranO When you conduct a trial w/ short duration, not many people die. So most people’s reported “life duration” is the duration of the trial (say 5 yrs if that’s the f/u period). That’s why that data point is meaningless. You’d need long duration trial to know how much it extends life

@KieranO LDL-C is also not predictive for secondary prevention. Its lowering with drugs (but not diet) extends life by only days and high numbers needed to treat for that effect

LDL-C is not a good predictor for heart disease. This was a finding of the famous Framingham study--in the 1970s. Replicated in other studies. So, why has LDL-C remained the focus of cardiology for so long? Very likely bc statins, the most profitable drug in history, treat it.

I thought I ❌ade the field look better 🤪

Michigan has not left the field and is guarding the M 👀

𝐂𝐢𝐧𝐞❌𝐚

Beautiful 🥹

@drjohnm This is using LDL-P rather than ApoB. pubmed.ncbi.nlm.nih.gov/21392724/

@drjohnm I don’t know that answer to that. When ApoB and LDL-C are discordant (20-30% pts), risk follows ApoB. So, it is especially useful at identifying people falsely felt to be lower risk due to a low LDL-C. The impact on pts with discordant values ≠ the impact on concordant pts

Truly curious question for my prevention colleagues. How much does ApoB modify 10-year risk calculations? If it isn’t a lot, why do we measure it at all?

The average caloric intake in the USA is 3540 kcal/day (FAO Data) The average physical activity in the USA is less than 20 minutes per day The average person is overweight/obese But you think seed oils explain the health crisis? You need to get your head examined

Visma-LAB's strategy in 3 sentences. #TDF2025 1️⃣ Reduce the difference in explosiveness between Tadej & Jonas by making the stage harder, so Jonas can follow Tadej's attack. 2️⃣ Isolate Tadej before the final climb, so he doesn't have a lead-out, so Jonas can follow Tadej's attack. 3️⃣ Throw shit at Tadej every day, hoping it results in a weak moment or a capitulation later in the race. (We have not seen this be effective since the TDF 2023.) I don't think it will work, but it's not rocket science. Is this an "expensive" strategy energy-wise? Yes, but if they don't do it, Pogačar drops Vingegaard in the mountains anyway. UAE also had an "expensive" strategy today, keeping a non-dangerous breakaway too tight all-day. Healy can have 10 minutes in GC and Pogačar still easily beats him by Paris.

RFK Mickey mouse dietary guidelines sneak preview - lard is heart-healthy now - seed oils cause autism - M&Ms lose dyes, add tallow - raw milk counts as vegetable - supporting references that don´t exist but it´s just a "formatting error"

@olsonplanner @MaritHealth This data is substantially underestimating the pay gap.

The pay gap between academic vs non-academic jobs in some specialties blows my mind every time. Got this from @MaritHealth Allergy - 34% ?? Plastics - 22% ?? PMR - 21% ?? Wow

So much happened today, but this has to be one of biggest highlights of the day… Wout van Aert almost fell off the bike after finishing the pull for the Giro winner Simon Yates.🫡 🎥: Adam Blythe #GirodItalia

Chapeau to Yates, Wout, and Visma!

🇮🇹 #GirodItalia Sir Simon Yates. 🩷 What a day, what a Giro, what a team...

Wout has finished his masterpiece, he almost fell off his bike after pulling for Simon. CHAPEAU WOUT! #GirodItalia

On KETO-CTA by ⁦@drjohnm⁩ “…on the authors’ messaging. It’s been egregious and antiscientific... I don’t know what the solution is for this behavior, but I oppose it in the strongest terms.” medscape.com/viewarticle/no…

LDL & ApoB levels don't matter for heart disease? Let's talk about the Keto-CTA LMHR study (PMID: 40192608) that got everyone pissed off I'm late to the party & don't have a ton more to add other than what people like @DrNadolsky & other's have pointed out but for those who may have not seen these other takes I'm going to give my take The core claim of this study is that LDL-Cholesterol & ApoB levels do not correlate with plaque progression But let's look at the actual data shall we?

Take a watch and listen of Peter Attia at the NY Times Well Festival -- Peter's part of the video (starts at 6:48:15 and is about 30 minutes): youtube.com/watch?v=Nw-tbX… @nationallipid @society_eas @ASPCardio @escardio @FamilyHeartFdn

Ohio State’s WR room in the spring of 2021 featured six first-rounders: Garrett Wilson, Chris Olave, Jameson Williams, Jaxon Smith-Njigba, Marvin Harrison Jr. and Emeka Egbuka. elevenwarriors.com/ohio-state-foo…