Bruno Di Stefano

1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵nature.com/articles/s4158…

Very excited to share our Molecular Cell @MolecularCell on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators! cell.com/molecular-cell…

Dr. Bruno Di Stefano (@DiStefano_Lab), Stem Cell Reports Early Career Editor , will be at the American Society of Hematology Annual Meeting in Florida, USA 6-9 December 2025. Connect with him to discuss whether your research is fit for publishing in Stem Cell Reports!

@GallowayLabMIT @kaseyslove Thank you to @kaseyslove and @GallowayLabMIT for the thoughtful and insightful commentary on our work in @NatureBiotech 🙏

Sure you can profile RNA but does that actually tell you what a cell will do? Or what it was doing? Here's a fun reflection led by @kaseyslove on the recent work from the lab @DiStefano_Lab. Their excellent study shows that microRNAs sequester mRNA from the preceding cell fate in P-bodies. Food for thought on how much we can (and cannot) see in profiles of RNA and how we might harness natural sequestration pathways to improve cell fate programming

Modulating RNA condensates to control cell fate #NBTNV go.nature.com/4iyZmGv

Elevate your career in stem cell science! Become an ISSCR member to enjoy exclusive benefits: complimentary webinars, preferred rates for events including ISSCR 2026, publishing benefits, & access to an international network. Join today 👉 bit.ly/4eOL2H1 @DiStefano_Lab

Excited to share our new study uncovering and overcoming the molecular drivers of interspecies PSC competition to improve human chimerism in animals. Big congratulations to first authors Yingying, Hai-xian, and Saku, and to our collaborators! cell.com/cell/fulltext/…

Meet Early Career Editor Bruno Di Stefano (@DiStefano_Lab) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!

This is one of the most interesting papers that I have ever read!

8/ Huge thanks to our editor and reviewers for invaluable feedback, and to our funders NIGMS, @theNCI, @NIAIDNews, @ASH_Hematology, @WorldwideCancer, @BePositiveFdn, @WebbWaringAwrds, NICHD, and @CPRITTexas for supporting this work!

7/ Our findings establish a fundamental, conserved role for P-bodies in cell fate specification and reveal novel strategies to manipulate RNA condensates for directing cell identity in regenerative medicine.

1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵nature.com/articles/s4158…

🤔How do you design a promoter for stable titration of expression? 💡Try programmable promoter editing with DIAL! 📰Now published at @NatureBiotech 🧵 [1/n] 🔗 below

Thrilled to be selected as an #ISSCR2026 Ambassador! The @ISSCR 2026 Annual Meeting will take place in Montréal, Canada on 8-11 July 2026 and features 4 days of cutting-edge stem cell science and global research talks. Learn more about the program: invt.io/1txbwbghvue

Programmable promoter editing for precise control of transgene expression go.nature.com/4h9wlR1