Bruno Di Stefano

1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵nature.com/articles/s4158…

I’m thrilled to share that our paper is out in Molecular Cell! We developed Ribo-Tweezer, a new technology that lets us rapidly and reversibly remove specific proteins from mature ribosomes to ask what they actually do in translation.

I don’t tweet much so I’ll keep this simple We are looking to recruit 1-2 new postdoctoral fellows, to study human hematopoietic development, from both basic and translational perspectives, using iPSCs. Please reach out via email for more details if interested!

My lab @bcmhouston is hiring a postdoctoral fellow to study hematopoiesis and leukemia using innovative degron mouse models, RNA recording technologies, and functional genomics approaches. If you are interested, please see the position details below:

Interesting symposium on ribosome heterogeneity sponsored by Science. Registration is free: us02web.zoom.us/webinar/regist…

Very excited to share our Molecular Cell @MolecularCell on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators! cell.com/molecular-cell…

Dr. Bruno Di Stefano (@DiStefano_Lab), Stem Cell Reports Early Career Editor , will be at the American Society of Hematology Annual Meeting in Florida, USA 6-9 December 2025. Connect with him to discuss whether your research is fit for publishing in Stem Cell Reports!

@GallowayLabMIT @kaseyslove Thank you to @kaseyslove and @GallowayLabMIT for the thoughtful and insightful commentary on our work in @NatureBiotech 🙏

Sure you can profile RNA but does that actually tell you what a cell will do? Or what it was doing? Here's a fun reflection led by @kaseyslove on the recent work from the lab @DiStefano_Lab. Their excellent study shows that microRNAs sequester mRNA from the preceding cell fate in P-bodies. Food for thought on how much we can (and cannot) see in profiles of RNA and how we might harness natural sequestration pathways to improve cell fate programming

Modulating RNA condensates to control cell fate #NBTNV go.nature.com/4iyZmGv

Elevate your career in stem cell science! Become an ISSCR member to enjoy exclusive benefits: complimentary webinars, preferred rates for events including ISSCR 2026, publishing benefits, & access to an international network. Join today 👉 bit.ly/4eOL2H1 @DiStefano_Lab

Excited to share our new study uncovering and overcoming the molecular drivers of interspecies PSC competition to improve human chimerism in animals. Big congratulations to first authors Yingying, Hai-xian, and Saku, and to our collaborators! cell.com/cell/fulltext/…

Meet Early Career Editor Bruno Di Stefano (@DiStefano_Lab) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!

This is one of the most interesting papers that I have ever read!

8/ Huge thanks to our editor and reviewers for invaluable feedback, and to our funders NIGMS, @theNCI, @NIAIDNews, @ASH_Hematology, @WorldwideCancer, @BePositiveFdn, @WebbWaringAwrds, NICHD, and @CPRITTexas for supporting this work!

7/ Our findings establish a fundamental, conserved role for P-bodies in cell fate specification and reveal novel strategies to manipulate RNA condensates for directing cell identity in regenerative medicine.

1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵nature.com/articles/s4158…