Divya P. Kumar (She/Her)

🌟21st April 2025 🌟 8 years of being a mom, and the day my daughter turns 8 — the most beautiful reminder of why I hustle every day. Honored to receive the Scroll of Honor — a nod to the countless women who are doing it all. (1/3)

@shivaramsingh @PrajnaAnirvan Thank you Sir 🙏🏻

Happy to share this recent publication [in press]. Thanks mainly to @DivyaKumar182 and @PrajnaAnirvan Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolism file:///C:/Users/scb_g/Downloads/s10020-025-01417-w_reference.pdf Abstract: Background & aims Metabolic dysfunction-associated steatohepatitis (MASH) is a multifactorial disease driven by complex molecular mechanisms. Identifying key regulators is critical for developing targeted therapies. Here, we demonstrate the impact of the loss of the apoptosis-antagonizing transcription factor (AATF) on hepatic lipid metabolism and MASH progression. Methods A preclinical mouse model recapitulating human MASH was established by feeding C57Bl/6 mice either a chow diet (CD) or a western diet with sugar water (WD). Hepatic AATF silencing was achieved by tail vein injection of siAATF delivered by adeno-associated virus 8 (AAV8) using a liver-specific thyroxine-binding globulin (TBG) promoter. In addition to histological, biochemical, and molecular biology evaluations, mechanistic insights were obtained through whole transcriptomic and untargeted metabolomic analyses. Results AAV8-mediated specific knockdown of AATF in hepatocytes significantly reduced body weight, liver weight, and insulin resistance in mice fed a western diet (WD). However, no such effects were observed in mice fed a chow diet (CD). Further analyses showed reduced liver injury, steatosis, and steatohepatitis in WDsiAATF mice. Transcriptomic analysis demonstrated that AATF loss alleviated cellular stress, inflammation, and fibrosis in WD-fed mice. Moreover, AATF silencing altered lipid metabolism, notably by decreasing hepatic lipogenesis in WD mice. Interestingly, untargeted metabolomics revealed increased glycerophospholipid biosynthesis and fatty acid β-oxidation in WDsiAATF mice. Conclusion Our findings reveal a previously unrecognized role of AATF as a central regulator of hepatic lipid metabolism in MASH, acting through the AKT–mTORC1 signaling pathway, and establish its inhibition as a promising therapeutic strategy for the treatment of metabolic liver disease.

@aktilaiyan @sankha_shubhra Surprised with the CV but anyways, green card in 2 months ? 🤔😳

@sankha_shubhra Exactly my thoughts. How did foreign universities consider this candidate with so many publications at the initial year of his PhD?

Sympathize with the sentiment, but the story shared seems ridiculous! Fake or not- cannot comment without knowing the case. 17 publications after 1.5 years of PhD suggest unscrupulous means or meaningless review articles or networking rather than actual work- especially in biological sciences. Citizenship in Europe/US as soon as eligible and wanting to return to India for a 40K per month job to a non-descript university rather than a premier one like say BHU (which used to give us online interview options long back)- again ridiculous. 103 reviews completed within 1.5 years of PhD (essentially as a student)- one is simply not capable or trained enough to review anything at that stage- even if a genius, the numbers are overwhelming. So this is like Swiss Cheese. And it is evident (while agreeing with the general sentiment of us losing talent), that most Indians on X cannot pick up fakery from the real! @abandopa @SAnsumali @Kishor_Ayu @abhas_rewcie @AnuragSinghBio @aktilaiyan

@NathSomsubhra Thank you!

@DivyaKumar182 Heartiest congratulations

🎅Santa came early this year! 🎅🎄 Thrilled to share that our manuscript has been accepted in Molecular Medicine—a wonderful end-of-year gift and a great way to wrap up 2025. Wishing everyone a joyful holiday season and a strong start to the new year. #smallwin #celebration

@therakesh_kr Thank you!

@DivyaKumar182 Many congratulations ma’am

@urssahu Thank you, Bhavani

@DivyaKumar182 Congrats Divya 🙂

@ShilpySharma14 Thanks dear ❤️

@DivyaKumar182 Great.. excellent news.. congratulations 🥂.. happy for u dear

@SamratLabMohali @iubmb @insa_academy Hearty congratulations! @SamratLabMohali 💐

I'm delighted to be appointed on the INSA International Science Council National Committee of IUBMB (International Union of Biochemistry and Molecular Biology) @iubmb. Thanks, INSA (Indian National Science Academy) @insa_academy & I'm looking forward to my new role from Jan 2026.

@RakshitTatini @IBITF_IITBhilai Congratulations! Tatini

This interdisciplinary work—in collaboration with Dr. Suchetan Pal , @IBITF_IITBhilai explores how glycans on exosomes drive communication between cancer cells and the stromal microenvironment, promoting progression, immune evasion, and metastasis

Excited and profoundly grateful to share that our collaborative project on the intriguing role of glycans in exosome-mediated crosstalk in cancer has been recommended for funding by the @ANRFIndia

@RoyAHep @AnandVKulkarni2 @RadhaKDhiman @ajay_duseja @drsuniltaneja @docMPK @doc_arka @SahajRathi @drbabupgi @RohitMehtaniDM @DrArunKValsan @drnschoudhary Hearty congratulations! @RoyAHep and @AnandVKulkarni2 💐

Humbled to be awarded the OP Memorial Rising Star Award at ISGCON 2025. Moments like these rekindle why the journey is worth it. Grateful to all my mentors, colleagues and patients 🥂 to @AnandVKulkarni2 for winning the SR Nayak Researcher Award 🎗️Award twinning mode on✨

🙏🏻 A request to the Research Community: ChatGPT-Generated Reviewer Comments ‼️Let this not become yet another ‘elephant in the room’ within academic publishing- visible, damaging, and ignored. linkedin.com/posts/divyapku…

@abhijit_MLab Valid point. 🙌🏻

I decline to review for open access Js whose OAC is unaffordable. If I can’t publish thr bcoz of cost, y shd I offer free labour? Open-Access publishers: if reviewers r integral to your business model, offer full APC waivers to those who review a certain number of papers.

🤝 Let’s keep the process fair, transparent, and efficient — for everyone involved. (4/4)

We all respect the workload of editors, but as a community, let’s also respect each other’s science and time. 🙏 To journal editors and publishers: if you can commit to timely editorial handling, it makes a world of difference to the research ecosystem. (3/4)

⏰The Importance of Timely Editorial Decisions Every researcher understands that peer review takes time — quality and rigor can’t be rushed. But the initial editorial decision stage shouldn’t be a bottleneck. (1/4)

@NathSangeeta @RaviMLab @NGandasi @AKlabMIRM @SamratLabMohali @Jain_Lab Congratulations! Dr. Deepak and Dr. Sangeeta. First one is very special.

Congratulations to my first PhD student, now Dr. Deepak! Grateful to Co-PI @RaviMLab, DAC @SubbaRaoIISc, collaborators @NGandasi & @AKlabMIRM, and reviewers @SamratLabMohali & @Jain_Lab. A great feat—PhD in 5.5 yrs, 3 papers (BBA Mol Basis Dis, JoVE, Front Neurosci) + 1 bioRxiv!

@DrAmbrishMithal On my list for this week end, Sir. Will post my thoughts after reading. This book is the need of the hour.

Great to meet you Divya! Hope you like the book. Encouraged to see the response among the medical fraternity to "The Weight Loss Revolution". For anyone interested it is available on Amazon.

🌟 A serendipitous moment to meet @DrAmbrishMithal and receive his autograph on his book- “The weight loss Revolution”. It was an honor to be part of this insightful gathering.

🤝 Bringing together a range of perspectives, the session underscored a theme crucial to the growth of biomedical science in India: the transformative power of collaboration. (2/3)

Honoured to chair a session on “Collaborative Research in India: Opportunities and Challenges” by Dr. Nikhil Tandon at the ISMBR 2025 (21st Annual National Conference of Indian Society for Bone and Mineral Research). Thanks for the invite, @idrlakshmi (1/3)