A. Joseph Borelli, Jr., MD

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A. Joseph Borelli, Jr., MD

A. Joseph Borelli, Jr., MD

@DocBorelli

🩻 Radiologist & MRI clinic owner | Chaired committee writing U.S. MRI accreditation standards | Filmmaker | All tweets IMO | No investment/medical advice

Bluffton, SC Katılım Mayıs 2013
2.2K Takip Edilen3.6K Takipçiler
Whole Mars Catalog
Whole Mars Catalog@wholemars·
Jony Ive and LoveFrom only did the interior of the Ferrari Luce from what I understand. Not the exterior.
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squawksquare
squawksquare@squawksquare·
I’m sorry but $650k for a Ferrari EV? I love Ferrari but I’d rather spend $650k on a SF90 Straddle. $tsla.
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Yun-Ta Tsai
Yun-Ta Tsai@yunta_tsai·
The Grok Build team is one of the most productive teams I have worked with. I need something to adopt my diverse workflow from model training to validating the Cybercab manufacturing process. Their daily updates show their care for the products. I extend my sincere gratitude to the team. I hope you enjoy the same experience as I have.
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Anish Koka, MD
Anish Koka, MD@anish_koka·
Why in heavens would you permanently gene edit something that there are cheap , safe, effective reversible options for? Especially bc the PCSK9i story is that despite very low LDLs you still have a 13% residual risk of a coronary event? This is a salvage operation for a therapy that is almost no value except for hyper rich influencers who while not salivating over unneeded gene therapies are getting stem cell infusions from Himalayan mountain goats.
Crémieux@cremieuxrecueil

Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!

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Brandan
Brandan@herron_brandan·
🇺🇸 This one’s for my grandfathers. 🇺🇸 Both of them served. Both of them sacrificed. And both of them are gone now. Most people see Memorial Day as a long weekend. For me, it’s personal. These two men wore this country’s uniform, gave years of their lives, and never asked for applause. They just came home, raised families, and kept going. I wish I could sit across from them one more time and really say thank you. Look them in the eyes and let them know that what they did mattered. I am who I am because of the men who came before me. Rest easy, Granddads 🕊️🕊️ Your legacy lives in me. ❤️🤍💙 #MemorialDay #HonoringOurVeterans #GoneButNeverForgotten #FamilyLegacy
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LE Sylvie 💫
LE Sylvie 💫@sina39184138·
Normally, I don’t cry because I am a very strong person, but today I feel like I could.
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Morgan
Morgan@morganlinton·
Watching Grok Build think is pretty fascinating. Definitely noticing a change with the releases made this weekend, its become incredibly thoughtful. And the plans are getting insanely detailed, I mean just look at the architecture deep dive it did here.
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Seth Howes
Seth Howes@SethSHowes·
I just sequenced a human genome to 30× coverage entirely at home. As far as I know, this is the first time this has been done. I didn’t step foot in a lab once. Every step - from saliva collection, to running the sequencer - took place in a single room with a dining table + kitchenette. Six weeks ago, I had never done wet lab biology before. I used an Oxford Nanopore P2 Solo - the only commercially available sequencing device portable enough to do 30x human genome sequencing at home. Biggest takeaway - I could build something that combined software, hardware, and molecular biology far faster than I thought was possible. I can name >100 specific instances where AI helped me solve a technical problem that would previously have blocked me because I lacked access to a domain expert. For example: how do I save my sequencing run when my DNA extraction yield is 4x lower than I need it to be, and I have this limited set of reagents to hand? To make this work, I had to navigate multiple disciplines: - writing software to monitor sequencing runs and orchestrate remote GPU infra for basecalling - learning + executing 5 hour long molecular biology protocols - building a hardware device to quantify DNA concentration Apologies for the hyperbole, but I feel super lucky to be living in 2026. A few weeks ago I decided to sequence a human genome to 30x at home. Then I actually did it. And I did it really quickly.
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Seth Howes
Seth Howes@SethSHowes·
I’ve wanted to do this for a decade. But I never did - I refuse to give any company my DNA. It is me. So this week I sequenced my genome entirely at home. Literally on my kitchen table. I never exposed my DNA sequence to the internet. Not at any point. I used a MinION to do the sequencing (it’s smaller + weighs less than an iPhone). I used open-source DNA models for the analysis (Evo2 and AlphaGenome) running locally on a DGX Spark and Mac Studio. I traced mechanisms behind my family’s multigenerational autoimmune conditions that no clinician has been able to understand. When I set out to do this I didn’t know if it would actually work. It does. Your genome is the most private data you will ever have. You probably shouldn’t let it leave your house.
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Patrick Collison@patrickc

I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools. With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments. Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know. I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars. (One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.) There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!

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Peter H. Diamandis, MD
Peter H. Diamandis, MD@PeterDiamandis·
Everyone is massively underestimating how FAST we're about to change our world as AGI/ASI comes on line. We're on the verge of massive scientific breakthroughs (SolveEverything.org) that will enable accelerated abundance, from Longevity to Energy breakthroughs. Don't Blink.
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FSD Yinzer
FSD Yinzer@FSDyinzer·
If you’re looking for honest FSD 14.3.3 feedback and are expecting a sunshine and rainbows review, I have bad news for you. This is a rough build. LOTS more details and video examples coming later today.
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A. Joseph Borelli, Jr., MD
As a result of AI, what if inequities are greater, but those that need the most care are given far more access than what they have today? That's the most likely initial outcome. Another Inverse Care Law: Those most concerned about inequity are the least likely to give up their access to care on behalf those with less access.
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Eric Topol
Eric Topol@EricTopol·
The Inverse Care Law. The people who need medical care the most tend to get the least access. It will take deliberate and extensive efforts for medical AI not to exacerbate health inequities, by @ejosipcar We've seen some examples where AI reduced inequities and need to build on that. thelancet.com/journals/lance…
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Brandan
Brandan@herron_brandan·
Interesting post.
Hamid@hamids

Here are the facts about @elonmusk: He USED to be great! He made the impossible possible. But in the past 4 years in particular, he himself has become a "pompous retard," as demonstrated by this tweet where he calls some kid a "pompous retard" because the proud kid has "PhD at 19" in his bio. The kid is now 22! It's no wonder Elon is behind on everything! He's become such an ass, that NO TALENT WANTS TO WORK FOR HIM! Let's look at Elon's record over the past 4 years: Let's start with $TSLA: - Talent has flooded out of Tesla. Big names, like Andrej Karpathy (@karpathy), previously heading Tesla AI team, left years ago (now at Anthropic). Head of RoboTaxi left not long ago also. Heads of other teams/vehicles/research have also left. The talent drain has been across the board and Tesla is feeling it! - RoboTaxi, launched 1 year ago in June, was expected to have over 1 Million vehicles by now. So far, around 20 vehicles! And don't ask about the accident rates! - Optimus, originally planned for launch last year with "thousands of units" with "millions by 2026/27" and eventually "billions" has not delivered even 1 yet. Plus ALL the demos of Optimus have been remote operated with some embarrassing fails! Other robotics companies, like Figure, are driving circles around Optimus with their demos! - Tesla Solar: practically dead. Solar Roof: no longer even talked about! - Tesla Semi, Roadster 2, Model 2 (or $25K vehicle), all massively late or canceled! - Nearly EVERY Tesla project has fallen way behind. - Revenues: DOWN year-over-year for 2 years now! No obvious path to meaningful revenue growth in at least 2026. Profits: down massively...might go into red soon. On to SpaceX $SPCX: - First Booster+Starship demo launch happened in April of 2023. At the time, Elon set the expectation that there would be a new test launch about every 6 weeks or so, with expected "prep mission to Mars to take payload to prepare for manned missions to Mars by 2024 or 2026 at the latest." (paraphrased) 3 years later, we just got another Booster+Starship demo that was about on-par with the original. Sure a lot has changed/improved over the past 3 years, but this is a MAJOR letdown from expectations set by Elon. - Remember the "Dear Moon" launch of Starship with a 9-person crew filled with prominent artists, digital creators, and celebrities? That was supposed to launch in 2023! Quietly canceled. No update! - SpaceX Revenues: up just 33% year-over-year in 2025 and latest quarter (Q1 2026) was up just 15% year-over-year On X and xAI: - After two years of touting xAI's Grok as the absolute best AI, far superior to the woke OpenAI ChatGPT and "Miss"Anthropic's Claude, Elon finally admitted that xAI sucked and they needed to start from scratch a few months ago. He even admitted they mis-hired! - Twitter revenue was ~$5 Billion annually when Elon took over. Now, X (formerly Twitter) + xAI combined revenue is ~$3 Billion annually. Don't even get me started on the expectations he set with Boring Company and Neuralink, and what has been delivered so far! ---------------------------------- The facts are that in the last 4 years, Elon has become the pompous retard, not this poor kid, @iScienceLuvr. As a result, not many people want to work their asses off so that only Elon can get credit for all of their work with a Trillion-Dollar pay package while they work for 1/1,000,000th of that! (if they're lucky!)

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Elon Musk
Elon Musk@elonmusk·
@teslayoda The key is just closing the loop on solving progressively harder problems, which we have plenty of at my companies
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Tesla Yoda
Tesla Yoda@teslayoda·
Grok Build should watch and learn from Claude Code and Cursor inside Marcohard.
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