Dominique Grey

@stephanlivera Becoming the settlement layer IMO: exchange batch withdrawals, ETF balancing, treasury companies etc etc. Tradfi norms, processes etc have taken the transaction volume off chain, aggregated it, and only net settlement occurs on chain as needed. L2 do the same.

Did Lightning and other Bitcoin L2's scale "too well"? Is that why we have such consistently low fees nowadays?

@RogerSeheult Used to accelerate growth. Banned in the EU

Of course it absolutely has nothing to do with this. At all.

Just so you know this can happen. Bacteria found in the blood of a patient completely resistant to all antibiotics tested for. R = resistant

@CitizenBitcoin @L0RINC Datacarriersize still configurable in v30 for aggregate amount of allowed data per transaction (as multiple OP_RETURN outputs per transaction are supported) but marked as deprecated, is my (very limited) understanding

@L0RINC my understanding is those config options in the UI are to be removed (though still possible by editing a file) - is that wrong?

I spent more time trying to understand the core v knots debate this week. here's my updated understanding and thoughts: core logic flow: > policy rules define what a node will relay into its mempool, they are not consensus rules -> miners can mine “non-standard” txs anyway > op_return costs 4 wu/byte vs 1 for witness -> ~4× more expensive, anti-incentive for spam > current policy creates inefficient relay -> nodes reject, miners include anyway > restricting op_return pushes data into unprunable hacks -> permanent utxo bloat >projects embedding data do exist -> restricting op_return pushes data into unprunable hacks and permanent utxo bloat -> better to funnel into prunable, expensive op_return path core's case is focused on pragmatism. knots strongest arguments focus on principle: > configurability = sovereignty. removing policy knobs from core effectively reduces operator choice > slippery slope = relaxing rules signals it's ok to store non-monetary data on Bitcoin, encourages behavior that is inconsistent with bitcoin as exclusively a monetary technology, and erodes that cultural norm > growing non-monetary demand from that slippery-slope risks mempool bloat, higher fees, and tilting incentives toward miners/pools catering to data use core’s response to these specific concerns (drawing from the above): > config knobs that don’t affect miners are not sovereignty -> miners include whatever pays fees anyway > false sense of sovreignty -> operators think they’re affecting the network when miners decide inclusion anyway > real sovereignty = ability to run your own code -> forks like knots exist precisely for this reason > slippery slope? this isn’t endorsement of a principle. it’s harm reduction. op_return is already least harmful + most expensive. better to steer demand there than into permanent utxo junk. > mempool bloat happens with or without op_return -> data will just shift into worse forms (fake pubkeys, p2pkh) if op_return is too restrictive > fee market dynamics don’t change -> higher demand = higher fees, regardless of how the data gets in. at least op_return channels it into the least harmful path my conclusion: I now think it actually mostly addresses knots’ users most convincing concerns while improving efficiency and reducing potential harms to the unprunable utxo set I am sympathetic to knot's runners' views and respect my fellow bitcoiners who have been respectfully engaging in vigorous debate - I think they are correct on principle - and I have been running knots myself. but I now think core's approach is more pragmatic and efficient and, in it's effect, actually aligned with knots runners' principles of monetary maximalism and sovreignty. I think core could leave the config options in the interface to make it easier for users to run knots-like policies as a compromise as I do think policy choices can shape culture as default relay rules can signal what is “normal” or "correct" vs discouraged use of block space. but, in the end, I think preventing utxo bloat has a much bigger impact on the sovreignty of the network and is a stronger signal. still, we could do both. it's vital to bitcoin to have these kinds of disagreements and the intensity of the conversation is warranted given the stakes. we've been through many of these kinds of debates over the years. I came into the space at the culmination of the years-long blocksize war. The high level of the intellectual, philosophical, and even the emotional aspects of the debate was hugely influential on building my faith in bitcoin. no crypto project came close to that kind of rigor or intensity. ultimately I think bitcoiners are all here for revolutionary sovereign money. ideas about how we best achieve that goal should be rigorously stress tested in all forums where people want to debate it. I'm here for it. thanks to everyone who has weighed in. I read a lot of great content in stacker news and benefitted from my friends @reardencode and @tomer taking an hour of their time to discuss this matter on a space with me earlier this week -> x.com/CitizenBitcoin… tick tock, next block

@adam3us @LongInvestor85 Listen to the @bitcoinoptech podcast. Great way to see how core works and interacts with the ecosystem.

i think if you had the chance to interact in person with a group of protocol developers, you would feel confidence in this laser focus on bitcoin's long term success, focus on meritocrazy, taking feelings and emotions out of it. some-misteps from individuals on social media, people are human, but the overall effect is very calm, logic, reason, game-theory focused.

The desired outcome of keeping Bitcoin censorship resistant is shared by all. Just some people are less good at understanding network game theory and untangling critical thinking vs how they would like things to work. bitcoin runs on economic game-theory, not wishful thinking.

@NikoMcCarty Might this conserved inefficiency be a feature not a bug 🤔Couple of reasons in these 2 queries. Thoughts? perplexity.ai/search/please-…

Rubisco is (arguably) the most abundant protein on Earth. (LPP surely comes close, right?) It’s an enzyme that fixes CO₂ into sugars during photosynthesis. Unfortunately, as most people learn in school, Rubisco is inefficient. Sometimes it confuses O₂ for CO₂ and wastes energy. Plants make up for this in raw concentration; up to half the soluble protein in a leaf is Rubisco. People have been trying to engineer better Rubiscos for many decades, but it's not easy because the proteins are big, do not fold easily (they need chaperone proteins to help out), are made from 16 subunits in land plants. But there's a new paper in Nature Plants that looks really interesting. The TL;DR is that a group in Australia figured out how to express plant Rubiscos (and all SEVEN of their folding chaperones) using a set of 3 plasmids inside of E. coli cells. This enabled them to do "directed evolution" of Rubisco in bacterial cells, and quickly find Rubisco mutants that have higher enzymatic efficiency or that fold better. In addition to the 3 plasmids, the researchers also coaxed E. coli to make ribulose-1,5-biphosphate, or RuBP, which is the 5-carbon sugar that Rubisco smashes into carbon dioxide to make molecules of 3-PGA for central metabolism. Now, the clever bit is that you RANDOMLY MUTATE the three plasmids encoding the Rubisco to make millions of variants. Then, you transform those mutated plasmids into E. coli. If the E. coli do NOT make a functional Rubisco, RuBP levels build up and kill the cell; the molecule becomes toxic. But if the E. coli DO make a functional Rubisco, then they keep the RuBP levels in check and live just fine. Using this "screening assay," the researchers found 46 fast-growing colonies of E. coli. Two of those colonies encoded really useful mutations. One mutation (M116L) makes Rubisco about 25–40% faster. The other (A242V) makes it fold and assemble much more efficiently. They put this mutation into a "hybrid Arabidopsis–tobacco Rubisco," put that into tobacco plants, and measured growth. The plants with M116L grew 75% faster than wildtype. No guarantees this will scale to more useful crops, like wheat and corn and soybeans etc. But it seems like a nice in vitro assay for faster prototyping!

@MichaelOkun Which of these proposed treatments may be contraindicated if the patient is misdiagnosed and actually has Lewy Body dementia?

Parkinson's is no longer just a tremor: We must redefine Parkinson’s across every stage and every presentation. It will be a key to the future of our plan for this disease. Dr. Bhavana Patel and her Fixel based team just published a great paper in the book Cold Spring Harbor Perspectives in Medicine that adds to the evolving data shattering the outdated images of Parkinson’s disease and redefining it across prodromal, mild, moderate, and severe stages. It also summarizes where we are with treatments. We need geriatrics, primary care and all clinicians seeing tremors to get up to speed on Parkinson's and its many presentations. Key Points: - Prodromal Parkinson’s is real and detectable. Non-motor symptoms like REM sleep behavior disorder, constipation, and smell loss frequently show up years before motor signs. - PD is not just a movement disorder as it may be associated w/ depression, anxiety, orthostatic hypotension, urinary dysfunction, and cognitive decline. These features can precede or overshadow the tremor which is not required to be present for a diagnosis. - New tools are redefining early diagnosis. Skin biopsies, seeding assays, AI based MRI scans, smell tests, REM sleep history, and levodopa challenges are changing how we recognize early PD and its mimics. My take: There were 5 points that resonated with me about this paper and of course please consider I am biased as I was an author. 1- Parkinson’s isn’t just an old man’s disease. It affects people in their 20s, 30s, 40s, and 50s and beyond. It doesn’t always start with a tremor. 2- You can spot it earlier than ever. If you’ve lost your sense of smell, act out dreams or have chronic constipation talk to your health care provider, or to a neurologist. 3- There are multiple stages of Parkinson's and we have methods and treatments for each one. From early signs to advanced care, we now personalize treatments based on your stage. 4- The picture of Parkinson’s is changing. It’s not just about stiffness or shuffling. It’s about sleep, mood, memory, and more. 5- Early action may translate to better outcomes. Getting an early diagnosis will open the door to exercise, medications, and lifestyle changes that may slow progression. Later, there are lot's of advanced treatments like pumps, FUS and DBS. Along the way don't forget to use PT, OT, Speech and the multi-disciplinary team. Spread the word: The face of Parkinson’s is evolving, and so is the science. cshlpress.com/default.tpl?ac… #Parkinsons #Neurology #BrainHealth @ParkinsonDotOrg @FixelInstitute

@TheBlueMatt @PrestonPysh Several relevant episodes in the Optech podcast @bitcoinoptech

Fair enough. I do recommend doing more research and thinking on the broader OP_RETURN topic as well. While the first principle “I don’t want it on my node, no reason anyone should be forced to have it on their node” reasoning sounds great in theory, it’s only once you dig into the numerous technical issues that it becomes a really obviously bad idea for the bitcoin network.

@AAStack Know the law? No confiscation required. All underground mineral resources belong to the state in France, unfortunately

One story. Two lessons! Can you see them?

@Plinz x.com/primal_app/sta…

Does it make sense to build another Twitter fork, with user controlled curation, intelligent bot filters, no deboosting of links, politically neutral leadership, free speech, thread moderation, …? True Twitter has never been tried

For the first time in my life I just drove a keyless modern car that told me what to do, and had tons of small things I couldn’t override — when to put on brights, when to speed up suddenly, all in the name of the safety algorithm, etc — and I’m surprised with how angry and sad it made me

@LogTech1999 Fantastic teacher. Vivid memories of his systems dynamics course at Sloan introduced with a great game demonstrating the build up of traffic jams

In the 1960s, MIT Professor Jay Forrester created something that changed the way we think about supply chains—The Beer Game. This game is a simple simulation, but it messed with the minds of thousands. Here's the game:

@SwaledaleMutton @Cynfab3 Perhaps some downsides for the cattle which may only occur longer term. Microbiome disruption is rarely without consequence perplexity.ai/search/why-do-…

@JoshMandell6 @ChuckDieselETH Believe it’s possible to pay dividends in specie under US law subject to articles of association and shareholder approval. NOT a lawyer

@ChuckDieselETH Would be illegal unless law change I think

Usually, I don't address someone else's method if I don't know and like them. In this case, though, I really do want to see if I can change some minds to thinking about using this quick transfer through USD as an equalization. I think over time I may get some ppl to see that BTC per share is probably not ULTIMATELY useful because it is not deliverable. You cannot trade your shares for BTC at that rate. Therefore, it is a theoretical construct.

@thelowcarb_rd Methane also ultimately oxidises to produce carbon dioxide and water. Why mess around at all? 💰

BOVAER. Should you be worried? In short: no. Let me explain... Firstly, wtf is it? It's classified as a "feed additive". The active ingredient is something called 3-nitrooxypropanol (3-NOP). Chemically, this is a primary alcohol (similar to ethanol) and a molecule of organic nitrate stuck together. Stick with me because it gets interesting... So this 3-NOP stuff stops a very specific enzymatic reaction in the cows rumen (the largest part of it's stomach). See the image. Everything you see in the image is what normally happens. 3-NOP enzymatically blocks ONLY the last step to prevent methane forming. What happens instead is the cow produces something called NOPA -> then HPA -> then eventually lactose and carbon dioxide. We know this because some (thankfully) paranoid scientists radioactively labelled some 3-NOP, fed it to cows, goats and rats and followed what happens all the way to the end. From this experiment they also figured out that zero detectable 3-NOP ends up in the milk or meat. Link to that study: sciencedirect.com/science/articl… A separate study also did NOT find any 3-NOP ended up in the milk but the milk did have 21% more vitamin B12. This is probably because the cows stomach produced more microbobes that make B12. Link: sciencedirect.com/science/articl… So back to the question, should you be worried? Personally I don't see anything to be worried about here. None at all. That doesn't mean I think cows are burning the planet nor do I like the idea of the food supply being tampered with. That said I am happy this isn't gene editing and this isn't pumping cows with pharmaceutical drugs. I'm also happy I can continue enjoying my steak and butter. P.S. all the health warnings you're seeing about 3-NOP irritating the skin etc is because it's made with a primary alcohol. Pure ethanol does all the same stuff if you handle it directly.

@pmarca @elonmusk @VivekGRamaswamy Start with FATF

A criminal conspiracy to deny rights granted by the Constitution is illegal on the part of everyone involved. Are bank managers victims of government coercion? Or conscious perpetrators? Or both? Let’s find out! Cc @elonmusk @VivekGRamaswamy

@PunterJeff Allianz has a large asset mgt business, check the various legal entities within Allianz that bought the convert 😜

Hol up! Allianz, the LARGEST INSURANCE COMPANY IN THE WORLD (by assets), purchased 24.75% of $MSTR $3B 0% convertible debt?!? Wonder who saw that coming?!?! Wait until other global insurance companies figure this out Going so much 🟩👆🏼Higher

@WazzCrypto France requires a license for betting operations and generally does not levy income tax on personal winnings

French guy makes $50 Million bag on Polymarket, and the regulators IMMEDIATLY rush to ban it 😭😂😂 Can't be having any Winners in Europe This whole continent is a fuckin joke at this point

@T_Nenninger twitter.com/jp_koning/stat…

« Prends ça dans ta gueule, l’Euro ». Le baiser de la mort.

@HalCranmer Empty the bottle, replace with whole milk, mct oil, whey protein, an egg yolk, glycine powder (sweet taste), creatine power, 100pct cocoa powder or natural vanilla. I also added Mg and beef gelatin powder. Switch discretely….

Just a reminder that the Ensure protein drink you’re feeding to Grandma or Grandpa has sugar as the second ingredient and maltodextrin as the third ingredient. And guess what..insurance may cover the purchase of it!

@brian_trollz Learnt a lot from BD and Bitcoin Adult Swim

Sometimes I wonder if the time I spent in this space was completely wasted in all regards except making myself money.