Don Nicholson

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Don Nicholson

Don Nicholson

@DonWNicholson

BioTech guy. Ex-BigPharma. Father, husband, sailboat racer & guitar aficionado. Tweets are mine.

Cambridge, MA Katılım Mart 2015
532 Takip Edilen1.9K Takipçiler
Don Nicholson
Don Nicholson@DonWNicholson·
@AlexHarding7 Such uninformed speculation, from someone I so highly respect. Read the manuscript, and consider these points as well:
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Alex Harding
Alex Harding@AlexHarding7·
Weight loss in rodents is often the first sign of drug toxicity. How does one distinguish that undesired form of weight loss from a desired treatment effect for obesity? Just other cageside findings and histopath? Seems tricky unless you have a v wide TI. nodthera.com/news/nodthera-…
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Don Nicholson
Don Nicholson@DonWNicholson·
Pure CDN talent. Don't miss the flute.
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Don Nicholson
Don Nicholson@DonWNicholson·
Very cool clinical proof of mechanism: inhibition of SLC6A19-mediated re-uptake of phenylalanine in the kidney. JNT-517 modulates a novel, cryptic allosteric site to do so.
Jnana Therapeutics@jnanatx

Today, we reported positive topline results from our Phase 1a clinical study of JNT-517, a potential first-in-class oral treatment for #PKU. JNT-517 demonstrated proof of mechanism and was safe and well tolerated. The Phase 1b is now open for enrollment. ow.ly/3Swq50OAIW3

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Joanne Kotz
Joanne Kotz@JoanneKotz·
We are thrilled to be working with fantastic colleagues at Roche to leverage our RAPID platform to advance programs targeting challenging-to-drug targets, including this immune protein-protein interaction. jnanatx.com/jnana-therapeu…
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Moderna
Moderna@moderna_tx·
Moderna and @generationbio announced today that the two companies have entered into a strategic collaboration to combine Moderna’s biological and technical expertise with core technologies of Generation Bio’s non-viral #genetic medicine platform. The collaboration aims to expand the application of each company’s platform by developing novel nucleic acid therapeutics, including those capable of reaching immune cells, to accelerate their respective pipelines of non-viral genetic #medicines. Read more: investors.modernatx.com/news/news-deta…
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Don Nicholson
Don Nicholson@DonWNicholson·
Hey fellow vinyl lovers. Great album, especially the A side. ‘Strange Conversation’ a must listen.
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Disc Medicine
Disc Medicine@DiscMedicine·
We are delighted to announce a $62.5 million financing, led by @BainCapital. This investment adds to our financial strength during an exciting year for Disc as we look towards multiple data readouts and trial initiations across our #hematology portfolio. globenewswire.com/news-release/2…
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Disc Medicine
Disc Medicine@DiscMedicine·
Disc is excited to announce a licensing agreement with Mabwell Therapeutics for novel investigational anti-#TMPRSS6 antibodies, including phase 1-ready MWTX-003, which will expand our portfolio of programs to control #iron homeostasis! Read more here: globenewswire.com/news-release/2…
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Disc Medicine
Disc Medicine@DiscMedicine·
Today we announced Disc has completed its merger with Gemini Therapeutics. The combined company, advancing Disc’s pipeline of hematology programs, will commence trading under the ticker symbol $IRON Read more: globenewswire.com/news-release/2…
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