Jonas Bille Nielsen

Our discovery of mutations in the CIDEB gene that protect against liver disease is published in @NEJM, leading to possible #RNAi therapeutics for NASH by Regeneron & Alnylam. 🚨 nejm.org/doi/full/10.10… A short summary of the key findings 🧬🧵↓

We are announcing a PhD Fellowship in dermatology and biostatistics at K.G. Jebsen Center for Genetic Epidemiology @NTNU_ISM! 🎉 You will be exploring serum metabolites from @theHUNTStudy for improved prevention and treatment of psoriasis and eczema.

Our latest research identified mutations in the CIDEB gene that are highly protective against nonalcoholic forms of liver disease. We're using this discovery to bring potentially promising new therapies to the clinic to help people with NASH. #RGCResearch

By studying the genome of ~540K individuals, we discovered that those with a mutated copy of the CIDEB gene have a 53% lower risk for NASH. Discover how we use this research to inform the development of potential therapies. #RGCResearch

The clever people at @NASA have created this deceptively simple yet highly effective data visualisation showing monthly global temperatures between 1880-2021. Watch until the end... Learn more here - svs.gsfc.nasa.gov/4975 #ClimateEmergency #ClimateCrisis #climate

The DNA asked who RNA was bringing to the holiday party❄️Can you guess their response?

What a milestone in genomics.

NEW today in @NatureComms from @cristenw and colleagues: Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease nature.com/articles/s4146…

Exploring and visualizing large-scale genetic associations by using PheWeb (Gagliano Taliun et al.) go.nature.com/2ALI4W6

Help track #COVID19 #COVID19DK in Denmark @SSI_dk.

Early RCT: no effect of of Lopinavir–Ritonavir vs. standard care in adults hospitalized with severe covid-19 in China (n=199). ~20% in-hospital mortality despite mean age 58y😟 nejm.org/doi/full/10.10…

#stratifiedlockdown for #COVIDdk #COVID19 seems reasonable next step. Current data suggest very low case fatality rate for previously healthy people <50y.

@SoerenLK AFIB + ischemia (not VT, narrow QRS seen in V1).

#EPeeps what is the rhythm (and diagnosis)? 65 yo male CABG app 6 mo ago. Walks into primary hospital with chest pain - referral to heart Centre planned but goes into cardiac arrest w non-shockable rhythm and dies before

Can I suggest we just use the acronym PGS for Polygenic Score instead of PRS? The word "risk" though it has a basically precise statistical definition has a terrible connotation in general parlance. #ASHG19

Planning your #ASHG19 Friday yet?! I’m as biased as euro PRS applied across ancestries, but highly suggest “Transferability of PRS Across Populations” @ 9 AM in Hall B. I’m co-moderating talks by @popgenepi, @genandgenes, my @umichsph colleague Pedro Orozco del Pino, & @dudutchy!

Former @LabWiller postdoc @DrJBille is presenting his work on loss of function variants’ effects of liver related blood traits #ASHG19