Erik Sayle

1.5K posts

Erik Sayle

Erik Sayle

@ErikSayle

Tech nerd, agricultural microbiology and data science. #AgTech #ML #Microbiome #Singularity

San Francisco, CA Katılım Haziran 2018
554 Takip Edilen157 Takipçiler
Erik Sayle
Erik Sayle@ErikSayle·
@KrutikaKuppalli I vote on the left but don’t understand why it’s a big deal to bring my ID to vote? I think he meant a bar. I carry my ID everywhere anyways. I think there are many much more important issues than voter ID.
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Aadil Brar
Aadil Brar@aadilbrar·
An Indonesian fisherman just pulled a 3.7-meter torpedo-shaped Chinese spy sensor out of the Lombok Strait, near Gili Trawangan. Defense analysts have identified it as a Deep-Sea Real-Time Transmission Mooring System made by China's 710 Research Institute, a body focused on underwater attack and defense. Here is why this is a big deal. The device sits anchored to the seafloor and uses acoustic sensors to detect submarines passing by, transmitting real-time data back to shore. Sound. Target information. Continuously. It bears the logo of CSIC, China's state shipbuilding corporation. The Lombok Strait is one of the most strategically important waterways on the planet. It is the deep-water corridor between the Indian and Pacific Oceans, and the primary route for Australia's future AUKUS nuclear submarines to reach the South China Sea and any Taiwan flashpoint. Beijing's response? "There is no need for excessive interpretation or suspicion." Analysts say this device suggests China may already have a network of these sensors across Southeast Asian sea lanes, building a real-time picture of undersea conditions to give its submarines a wartime advantage. Indonesia will investigate. Then go quiet. It happened the same way in 2020 when a Chinese underwater glider was found near Sulawesi. Jakarta is simply not in a position, politically or economically, to push back loudly against Beijing. Full story here: abc.net.au/news/2026-04-1…
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Patrick Collison
Patrick Collison@patrickc·
I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools. With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments. Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know. I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars. (One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.) There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!
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Erik Sayle
Erik Sayle@ErikSayle·
@ramez I actually had a dream about it last night. It’s pretty nuts. How do we defend against it? I guess an arms race of CyberGPTs (EvilGPT vs GoodGPT)
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Erik Sayle
Erik Sayle@ErikSayle·
@ramez I miss the left voices fighting back against propaganda but I’m ok because I have logic and can think for myself. Glad you’re here to fight the good fight of moderate views. The far right here are obvious clowns but there are still solid thinkers here, left & right.
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Erik Sayle
Erik Sayle@ErikSayle·
Super cool tech. Amazing times.
Steve Jurvetson@FutureJurvetson

Introducing Ⓛ 𝗟𝗔𝗖𝗘 𝗟𝗜𝗧𝗛𝗢𝗚𝗥𝗔𝗣𝗛𝗬 A novel approach to chip-making that can extend Moore's Law 10x beyond what is possible with light — to atomic resolution. News today: "Manufacturers use light-based lithography systems made by the Dutch company ASML, which dominates ​the market. Lace has developed a new approach. Instead of ​light, Lace's engineers have made a form of lithography that uses a helium atom beam. With that, the Norwegian company will be able to create chip designs that are 10 times as small as what is currently possible" "The main advantage of the helium atom beam is the industry could create features such as transistors, ‌the ⁠building blocks of modern chips, an order of magnitude smaller to an "almost unimaginable" degree, according to John Petersen, Scientific Director of Lithography at Imec, a research and innovation hub for the chip industry. The beam Lace will use to make chips is about the width of a single hydrogen atom, or 0.1 nanometer. ASML's lithography tools use ​a beam of light that ​is about 13.5 nanometers; ⁠a human hair is about 100,000 nanometers wide. Smaller transistors and other features would give chipmakers the ability to ramp up the performance of advanced AI processors well beyond ​the current capabilities. Lace's technology would enable chip manufacturers to print wafers at ​what is "ultimately atomic ⁠resolution" — reuters.com/world/asia-pac… Now hiring in Bergen and Barcelona: LaceLithography.com

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Alec Stapp
Alec Stapp@AlecStapp·
Solar energy never should have become polarized in the first place. Energy affordability doesn't need to be a partisan issue, and solar obviously has a critical role to play. Glad to see the admin changing its tune: "Signs the White House is yielding to it emerged last week when the Interior Department revealed it is allowing several large-scale projects it had blocked to resume moving through the permitting process, acknowledging such installations align with Trump’s energy agenda. In a call with reporters last week, Energy Secretary Chris Wright, who has called solar power 'just a parasite' on the power grid, also changed his tone. 'Is there a commercial role for solar power that can add to the grid affordable, reliable energy?' he said. 'Certainly there is.'"
Alec Stapp tweet media
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Erik Sayle
Erik Sayle@ErikSayle·
@FutureJurvetson @MikeHotDogMayor While I appreciate many of your investments I also appreciate that Taco Bell and eat there regularly for decades and bring tourist friends there. It’s a real joy to have an affordable restaurant on such a nice beach so that vast numbers of people can enjoy.
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Steve Jurvetson
Steve Jurvetson@FutureJurvetson·
@MikeHotDogMayor I almost bought that in 2005. It was for sale for $3M, quite a bargain if it were a home with all that beachfront real estate. But alas, when zoned as a restaurant, you have to offer meals to the public some minimum number of days. Tough call.
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Erik Sayle
Erik Sayle@ErikSayle·
@garrytan Growing up around Half Moon Bay the city and citizens fought for decades to NOT improve the entry roads to keep it from being developed. The ex mayor could not afford to live there after and moved home to Alaska!
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Garry Tan
Garry Tan@garrytan·
If you want to make the lives of Californians better, you build housing. Housing under-supply makes rent too high everywhere. But to build housing, it takes leadership and better policies that prevent small numbers of NIMBYs from gumming up every project for a decade
Sukrit Ganesh 🇺🇸 🥑 🚲🛩️@SukritGanesh

Another stereotypical California affordable housing ordeal: developer has spent 10 years battling NIMBYs to build a 71-unit low-density complex in Moss Beach, a small town near Half Moon Bay. State is paying tens of millions in subsidies. This is a region with tons of empty land.

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Wayne Hoy
Wayne Hoy@WayneHoy·
@Noahpinion Kokarri Firefly State Bird Provisions Khao Tiew Fikscue Thrive City
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Noah Smith 🐇🇺🇸🇺🇦🇹🇼
I'm on a quest to find every good restaurant in San Francisco. Give me your top 3 to 5 recommendations! Anything is good, from lunch cafes and bakeries to fine dining. No East Bay, no Peninsula...just San Francisco!!
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Erik Sayle
Erik Sayle@ErikSayle·
@EricLDaugh One of the smartest people I have ever known was Somali. Book smart, erudite and a sublime knowledge of character.
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Eric Daugherty
Eric Daugherty@EricLDaugh·
🚨 BREAKING - MATT WALSH JUST NAILED IT: "We all knew that the average Somali has an IQ that hovers around the level of mental retardation, scientifically speaking!" x.com/i/status/20085… "EVERYBODY KNEW what the Somalis were doing." 💯 "Half of Somalis live off $1 per day Something like 70% of the Somali population is below poverty. They have an economy that’s so primitive that it’s hard to even comprehend it.” "We KNEW there was NEVER a universe in which importing hundreds of thousands of these people was ever going to improve this country!"
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Erik Sayle
Erik Sayle@ErikSayle·
@RoKhanna I live in SF and vote and this billionaire tax is populist garbage that will hurt California and lower the tax base dramatically.
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Ro Khanna
Ro Khanna@RoKhanna·
Peter Thiel is leaving California if we pass a 1% tax on billionaires for 5 years to pay for healthcare for the working class facing steep Medicaid cuts. I echo what FDR said with sarcasm of economic royalists when they threatened to leave, "I will miss them very much."
Teddy Schleifer@teddyschleifer

NEWS: Larry Page and Peter Thiel are making moves to leave California by the end of the year to avoid a possible billionaires tax that could hit them where it hurts. With @RMac18 + @hknightsf. nytimes.com/2025/12/26/tec…

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Erik Sayle
Erik Sayle@ErikSayle·
@garrytan I live & vote in SF and support Grow SF against the old guard that tried ruining the City.
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Garry Tan
Garry Tan@garrytan·
This is coming from the same place as SF Supervisor Jackie Fielder who recently tried to ban R&D and laboratories (including cancer research and AI research) in her district. They hate tech so much they want us to leave. But we will vote them out instead.
Garry Tan tweet media
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Garry Tan
Garry Tan@garrytan·
This CA “billionaire” tax is an unrealized gains tax. A unicorn startup founder becomes a paper billionaire around $5B val. At YC we avg 2 to 4 per year (!) This will kill startups and innovation in California since a founder is illiquid while instantly on the hook for $100M
Teddy Schleifer@teddyschleifer

NEWS: Larry Page and Peter Thiel are making moves to leave California by the end of the year to avoid a possible billionaires tax that could hit them where it hurts. With @RMac18 + @hknightsf. nytimes.com/2025/12/26/tec…

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