First Star Ventures

We're getting a bunch of weird bio/AI people together on Thu 5/28 in Cambridge, come hang out! We're doing a fireside chat with some excellent founders: - John Capodilupo (CPO/Co-Founder @ThroneScience, prev CTO/Co-Founder @WHOOP) - Conor Loy, PhD (CEO/Co-Founder @romixbio)

as a peer to fervo, today feels like a good day to give them their flowers for their opening act. they started when nobody cared about geothermal or baseload power startups, trying to commercialize EGS; a technology with a 40+ year graveyard of failures. anyone who does this for a living knows how brutal that path was. they had to survive so many firsts and so much painful company building. now for the second act: they're sitting on 2B+ in cash now. and unlike fusion or fission, that capital is going to turn into real MWh on the grid. no celebrating technical milestones that nobody understands, no "power is just a few years away" promises. no, those billions will generate new power. because at the end of the day, geothermal is just drilling, hot rocks, and thermal power plants. we know how to drill. we're getting better at finding the hot rocks. and we damn sure know how to build and operate the plants. it's a pretty cool moment. the future is bright.

The 2026 State of Engineering Management Report finds that only 10% of teams report strong enablement and high adoption (of AI tools) across their organization. Head of AI & Research Nicholas Arcolano, PhD, and Engineering Manager Marilyn Cole react to this finding in this video. Explore the report for more insights here: jellyfish.co/2026-state-of-… #SEMR26 #AICoding #AITransformation #StateOfEngineeringManagement

Here's a look at the highlights from our humanless run from Houston to Dallas!

Join us May 28th for a #BOSTechWeek event: Heeding Nature's Call: Reading the Body with AI partiful.com/e/MyfKGX0Dl8Bi…

HUGE thank you to Kurt Knutsson and Fox News for doing a deeper dig on our humanless run from Houston to Dallas. Kurt said it best in his article: next steps are repeatability and scale, and we are ready to tackle those head on! Read the full interview with Kurt and Bot Auto's CEO Xiaodi Hou here. foxnews.com/tech/humanless…

See how easy it is to power your @stripe projects with Turso: as many databases as you want, to power as many things as you can dream of. turso.tech/blog/how-to-pr…

Excited to host an event for #BOSTechWeek Heeding Nature's Call: Reading the Body with AI Sign-up 👇 partiful.com/e/MyfKGX0Dl8Bi…

@patricia_klein_ @adamfuhrer @ayushsoni_io thank you for highlighting this. we commissioned a designer and were led to believe it was their solely team's work. we've reached out to @adamfuhrer

@adamfuhrer @ayushsoni_io @FirstStarVC

Extremely disappointed to see my work used and altered without my permission by @ayushsoni_io as branding material for a venture capital company. About a year ago, he reached out asking to collaborate. We had a few initial conversations, but ultimately didn’t reach an agreement and decided not to move forward together. Despite that, my work has now been used without my consent. Given his large following on Twitter, I think it’s important to call this out publicly, and I would strongly advise others not to trust or work with this person in the future. Below are direct comparisons of my work alongside the branding:

🇨🇭The future of cell manufacturing is coming to the heart of Europe! Next week, iOB COO @karol_jarzabek will be heading to Basel, Switzerland for Swiss Biotech Day 2026. As new approach methodologies gain traction, the need for efficient model development and scalable manufacturing continues to grow. Using the CellDiscovery™ platform’s parallel process development and CellForge™ cell and organoid manufacturing, @iOrganBio is providing our partners with The Right Cells, Consistently, At Scale. There’s still time to register for Swiss Biotech Day, see the link below. Event Details: 📆 May 4-5 📍 Basel, CH 🔗 swissbiotechday.ch @SwissBiotech @SBC_Biopharma #NAMs #Organoids #BioTech #Biopharma

AI is transforming go-to-market faster than anything we’ve seen in years, but it’s not replacing what actually drives revenue. Humans still close deals. On May 27, we’re hosting a Boston TECH WEEK by a16z panel alongside ShiftGroup and York IE, bringing together GTM leaders to explore how top teams are blending AI-powered workflows with the human skills that matter most. We’re especially excited to have Jellyfish’s CRO, Chris Ward, sharing his firsthand perspective on how modern revenue teams are evolving in real time. 📍 Boston | Jellyfish HQ 🗓️ May 27th, 5:00 –7:30 PM ➡️ Register here: partiful.com/e/3Xe3EyQwBuSE… #GTM #SalesLeadership #AI #BOSTechWeek

The FDA is replacing animal testing w/ human cell models. To do this, the field needs cell manufacturing that's precise, consistent, and scalable. @iOrganBio is how we'll get there.

🚧 The status quo of biological model discovery, development, and biomanufacturing is blocking progress on some of humanity’s greatest biomedical breakthroughs. At iOrganBio, we’re re-designing cell model discovery and manufacturing from the ground up, leveraging modern automation and machine learning as fundamental components of our system. Using rapid turnaround scRNA-seq, we are able to digitize cell state and automatically guide stem cell differentiation towards bioequivalency using in vivo cell states as a blueprint. Our platform unlocks the next stage of biotechnological development, treating cells as the complex and dynamic systems that we’ve always known them to be. Join us as we transform the way we use cells to cure disease and forge progress using The Right Cells, Consistently, At Scale. 🌐 Learn more about our tech at iorgan.bio ✉️ To start a collaboration with iOB, email partnering@iorgan.bio

Good news: portfolio co @ZanskarGeo on @tbpn and the boys get excited about geothermal energy 🌋⚡️ Bad news: @johncoogan calls it "Zainkar"

Nomic has partnered with Broad Clinical Labs to bring Omni 1000 into discovery and translational workflows. After profiling ~1M samples, we’re expanding access and embedding our platform into multi-omic & translational research. businesswire.com/news/home/2026…

"at 10:42 AM, Bot Auto became the first officially approved commercial autonomous vehicle operator in Texas." Congrats to Houston-born @BotAutoAV ! 🚚 🤖

✈️ Catch the iOrganBio team at these upcoming events around the globe! The development of new approach methodologies (NAMs) hinges on the reliability and consistency of the cells that make them up. From organoids to microphysiological systems, adoption of NAMs, iOrganBio is helping partners accelerate process development with the CellDiscovery™ platform and bridge the gap between development and scalable production using CellForge™ manufacturing. 🌐 Find out more about our team and technology by visiting iorgan.bio ✉️ To learn more about working with iOB email partnering@iorgan.bio #ProcessDevelopment #Biomanufacturing #iPSCs #NAMs #Organoids @WCM_Innovation @ncbiotech @NCLifeSci @SwissBiotech @SBC_Biopharma

We are now letting the first couple of people in for our private beta. If you haven't received anything from us yet, stay tuned! And if you want to deploy millions of databases to power your agents, with concurrent writes and all the goodies that Turso offer - securely, privately, with the option of deploying on our own cloud account, join the waitilist now! turso.tech/private-beta

Zanskar is completely reshaping the risk curve for geothermal power. Yet another first-ever achieved by the team. Huge

2026 Ride AI summit is in the books! Thank you to @ThomasWasson for leading a great panel with our CEO Xiaodi Hou!