fanbotao

#slidearchiveseries vasculogenic mesenchymal tumor #gupath #pathtwitter #pathoutpic 🔬 neoplastic vessels in smooth muscle stroma 1️⃣ post-ChT resections of primary mediastinal GCT with YST components 2️⃣ risk of sarcoma 3️⃣ risk of leukemia/myelodysplasia pubmed.ncbi.nlm.nih.gov/33136584/

#slidearchiveseries urothelial carcinoma, plasmacytoid variant #gupath #pathtwitter #pathoutpic 🔬discohesive single tumor cells, eccentrically placed nuclei, eosinophilic cytoplasm  💥high grade, poor prognosis 🙅🏻‍♀️do not use CD138 in isolation to distinguish from plasma cells

Did you know the chicken that crossed the road to get to the other SLIDE? Well, here it is :)

🧵 1/9 Elderly male. Metastatic colorectal cancer with liver mets. RAS wild-type — looks straightforward. Then the molecular profile comes back: HER2 IHC 3+. This changes the entire treatment plan. Here's why 👇

🚨 GIST TREATMENT MASTERCLASS – ULTIMATE EDITION 🔥 The most complete high-yield infographic you’ll ever need: ✅ Risk Stratification (Miettinen/AFIP table) – size, mitotic rate, site & rupture ✅ Choi Criteria (VERY HIGH YIELD) – why density drop beats RECIST in GIST ✅ Mutation-Based Algorithm (SUPER HIGH YIELD) – KIT exon 11/9, PDGFRA D842V → Avapritinib ✅ Complete Management Flow – Localized, Borderline, Metastatic & Special Cases ✅ Exam-critical pearls + Mutation & Treatment at a Glance table Precision oncology prototype • NCCN-aligned • One-shot revision gold Save this for rotations, boards & wards 📌 Tag a fellow/resident/fellow who lives on #MedTwitter 👇 RT if this just became your new GIST bible! #GIST #Oncology #MedEd #HemeOnc #PrecisionOncology #TargetedTherapy #Cancer #MedTwitter

#TooFarToDiagnose? A) Angiomyofibroblastoma B) Cellular Angiofibroma C) Superficial Angiomyxoma D) Deep Angiomyxoma #PathQuiz 🔬🧬 #GynPath

Based just on these two immunostains and the matching H&E, is this an IDH mutant astrocytoma or oligodendroglioma? #pathology #neuropath #pathtwitter

Second day of the first weekend of CAP #JobPrepBootcamp! ***Ovarian tumor frozen sections*** Clear cell carcinoma with adenofibromatous pattern can be signed out on frozen as “atypical epithelial proliferation in an adenofibromatous background”, defer to permanents (especially if atypia is focal) Helpful tips for real-world practice! #PathTwitter #JobPrepBootcamp #pathology #pathresidents #pathfellow #NIPPathX

#slidearchiveseries history of radical orchiectomy with pure teratoma, serum tumor markers (post-orchiectomy): AFP 537, increased to 964 and HCG 2; status post chemotherapy x 4 cycles ➡️ retroperitoneal lymph node dissection #gupath #pathtwitter

A nice Madura foot (Eumycetoma) presenting as a mass in foot. #pathology #dermpath #mycetoma

Ganglion cells at 36 weeks, 6 months and 12 years Dr. Kapur #USCAP2026 #pathology #PathX #PathTwitter #pedipath

⭕️Echinococcus cyst: A) Macroscopic hepatic cyst with white laminated membrane. B) PAS stain showing laminated and germinal membranes with protoscolices. #EverydayPathology 🔬Kristijan Skok, MD, PhD, Inst Pathol, Med Univ Graz; #ESPAlumni #pathology #PathTwitter #PathX

Spindle cell hemangioma was described years ago as a "hemangioendothelioma", but is benign, often associated with vascular malformations, and occasionally with Maffucci syndrome (enchondromas and hemangiomas), described years ago. PMID: 7661276.

Pleomorphic lobular carcinoma involving skin #breastpathology #pathology

This is a rather classic chordoma that has spread to the patient's lung, but there is lots more afoot! Modern Pathology helps us keep up! Sande WJ, et al. PMID: 39577663.

Kaposi sarcoma - note the hyaline globules (arrow). It is derived from lymphatic endothelium - confirmed a new way in Modern Pathology. Schneider JW, et al. PMID: 41478362; PMCID: PMC12860498.

@JenyaMD @anueru432 @dwnbird @KhalidMehr56617 @MdManagoli @Path4People @a_walk_home @bekirMD @AnaPath10 @neethususan123 @V_Masatkar @bskarthik2925 @CCKuempers1983 @p_athologist @capibarra_ @SansanoValero @rqbittenc 14. Back to lung adenocarcinoma growth patterns. The worst ones in terms of prognosis are solid and micropapillary. Problem for PGY1s: lung micropapillary is a bit different than other organs. Tumor in air!!

18. Clue no. 2 to melanoma: melanin pigment. It's brown and looks like hemosiderin. If you see this type of pigment in or near plasmacytoid malignant cells, your radar for melanoma should start going off!! Basic melanoma immunostains: SOX-10 (best), S-100, MART-1, HMB-45

#slidearchiveseries renal oncocytoma #gupath #pathtwitter #pathoutpic 🔬solid-nested growth, edematous stroma 🎨 CD117 positive, CK7 negative or scattered single/small clusters of positive cells, Hale collodial iron negative (apical luminal positivity may be seen)

These biopsies were from a patient known to have Peutz-Jeghers syndrome. Larger polyps are easy to diagnose (in this case, colonic), but early ones are subtle (small bowel).