George Liperis

🌟 Conclusion The oocyte cortex is a biomechanical decision-making layer controlling fertility, genome stability, and embryo survival and a powerful future tool for non-invasive IVF diagnostics. #ESHREjc

🧬 The Oocyte Cortex: Fertility’s Hidden Control Layer To find out join #ESHREjc on Friday 29th of January starting at 17:00 CET. @paolavigano @rvassena Enrica Bianchi and authors Giovanni Cotichio and Danilo Cimadomo Paper ➡️ pubmed.ncbi.nlm.nih.gov/41206604/ 🧵 #bluetorial 👇🏻

💉 ICSI = A Cortical Stress Test Injection funnel shape & persistence reflect cortical health and predict fragmentation, blastocyst quality, and pregnancy outcomes. #ESHREjc

📊 IVF Insight Mechanical tests show:
Cortical stiffness predicts blastulation better than morphology alone. Biomechanics > embryologist grading #ESHREjc

🎯 Cortex Stiffness Tunes Chromosome Fidelity Too stiff?
Too soft?
→ Both cause spindle failure and aneuploidy. There is a narrow “Goldilocks zone.” #ESHREjc

⚡ Fyn Kinase = Cortical Master Regulator Loss of Fyn → defective actin cortex, failed polar body extrusion, abnormal zona pellucida, chromosome errors → subfertility. #ESHREjc

🧱 Actomyosin Engineers the Cortex ERM proteins+actin+myosin sculpt polarity, actin caps, and spindle migration. Disruption = misalignment, meiotic arrest, aneuploidy. #ESHREjc

⚖️ Mechanical Polarity • Low-tension microvillar domain → sperm fusion
• High-tension amicrovillar domain → spindle anchoring
A 2.5× tension difference controls asymmetric division. #ESHREjc

🌀 Meiosis Triggers Cortical Remodelling TZPs retract → cortex reorganises → asymmetric forces reposition the spindle → polar body extrusion becomes possible. Bad cortex = poor embryos. #EHSREjc

🔁 Bi-directional Signalling Through the cortex:
• CC → oocyte: metabolites, meiotic arrest
• Oocyte → CC: BMP15, GDF9
→ Oocyte competence depends on cortical signalling. #ESHREjc

🦄 Oocytes Are Different Typical cell cortex: 50–400nm Oocyte cortex: ++ Thick ➡️ Thickness: Specialised functions. 🤝 Cortex: Communication Hub Hosts transzonal projections (TZPs): actin bridges that connect cumulus cells&oocyte, delivering nutrients and signals. #ESHREjc

🧶 The oocyte cortex is not just a membrane lining. It’s a specialised micromechanical command centre that controls meiosis, fertilisation, embryo integrity, and IVF success. #ESHREjc

🚨 Is the oocyte cortex the hidden key to egg quality, fertilisation, and embryo development? Join us for the next #ESHREjc 🗓 30–31 January ⏰ 17:00 CET start 📍 on @ESHRE academic.oup.com/humrep/article… Experts 👉🏻 @RitaVassena @PaolaVigano3

The new channel for science dissemination. Dont miss our #ESHREjc discussions also being hosted on bluesky 🦋 from ➡️ January 2026

@GLiperis @ESHRE @OmarRawi89 @juanjo_fraire @NoemiSalme30386 @juliauraji @AttilioDGM7 @FabrizzioHorta I totally agree with you @GLiperis. The problem is that the alternatives do not appear to be less harmful than paracetamol. I think the main rule for paracetamole should be "use the lowest effective dose in the shorter time" and for sure not prophylactic #ESHREjc

@juanjo_fraire @catiamalinina @Kristensen8511 @OmarRawi89 @ESHRE @juliauraji @AttilioDGM7 @GLiperis @Saara_riibeiro @NoemiSalme30386 I believe that, from a design perspective, it should not be difficult to conduct a retrospective clinical study examining the effect of paracetamol exposure during ovarian stimulation or embryo transfer, in order to obtain clinical evidence.

@catiamalinina @juanjo_fraire @OmarRawi89 @DKalaitzopoulos @ESHRE @NoemiSalme30386 @juliauraji @AttilioDGM7 @FabrizzioHorta 💯

@juanjo_fraire @OmarRawi89 @DKalaitzopoulos @ESHRE @GLiperis @NoemiSalme30386 @juliauraji @AttilioDGM7 @FabrizzioHorta Oh the problem with messaging! The balance is so delicate. From one hand, we cannot spread an anxiety-provoking narrative. From another angle, future parents should be educated and teamed up with physicians to make fully informed reproductive choices and acknowledge the risks

Q4: #ESHREjc Until prospective data arrive, what’s a proportionate counseling message for TTC/IVF patients needing analgesia, what alternatives, what timing advice, and how to avoid over-restriction that drives unsafe NSAID substitution? @ESHRE

@DKalaitzopoulos @ESHRE @OmarRawi89 @juanjo_fraire @NoemiSalme30386 @juliauraji @AttilioDGM7 @FabrizzioHorta Also important until further evidence to provide alternatives and individualised plans so pts use meds safely and not secretly #ESHREjc

@DKalaitzopoulos @ESHRE @OmarRawi89 @juanjo_fraire @NoemiSalme30386 @juliauraji @AttilioDGM7 @FabrizzioHorta I would think it’s important to avoid a blanket “no paracetamol ever” rule as it can push pts to unsafe substitutes. A suggestion would be to offer clear timing advice (avoid around trigger, implantation), but ok outside that window unless contra-indicated. #ESHREjc

The 4th discussion point on circumventing strategies #ESHREjc Join the discussion 👇🏻