Genomic Psychiatry

They called her the pretty one. She was a model and she was brilliant. THE ILLNESS DID NOT CARE. She was beloved. She was radiant. She married the love of her life. THE ILLNESS DID NOT CARE.

🧵Dr. Walss-Bass has written an extraordinary book, a one of a kind intimate voyage through the reality of schizophrenia, the cancer of mental illness Daniel R. Weinberger, M.D.

@BrandonLuuMD We showed that in mice too! See: pubmed.ncbi.nlm.nih.gov/27067014/

Great insight from the study on prestige over dominance! But it also shows prestige can snowball around below-average performers when perception overrides actual skill, raising the question: in noisy social/media environments, does the appearance of expertise (charisma, followers, confident signaling) often win out over real depth? Thoughts on how that plays into modern hierarchies?

A human tendency to value expertise, not just sheer power, explains how some social hierarchies form phys.org/news/2026-02-h…

@EricTopol Solid point on polygenic risk scores (PRS) adding value beyond traditional factors like blood pressure, cholesterol, and smoking for coronary artery disease risk. The new @NEJM review by @pnatarajanmd and colleagues highlights how these scores, drawing from hundreds of common variants, can stratify patients more precisely and support earlier preventive steps. This aligns well with the push toward prevention in medicine. PRS could help identify high-risk individuals who might benefit from intensified lifestyle changes, earlier statin use, or closer monitoring, potentially averting events. What do you see as the key next steps for broader clinical integration? Better multi-ancestry calibration, clearer guidelines on when to act on PRS results, or more prospective trials demonstrating outcome improvements? Looking forward to seeing this field advance. 🚀🧬

The Brazilian supercentenarians: 18 languages now. 300+ stories. Just this week another BIG story, this one in Switzerland's newspaper of record: NZZ- Neue Zürcher Zeitung. Founded in 1780, NZZ is one of the oldest newspapers still published. It is widely considered one of the top, most respected, and influential high-quality newspapers in the German-speaking world. Based in Zurich, Switzerland, its high-quality journalism is often compared to publications like The New York Times or The Guardian. Go check the NZZ article on the supercentenarians: archive.ph/c6Wq7. Get your browser to translate it for you. It is an excellent news story, worth reading.

“Perfect happiness” is a myth—and chasing it can be harmful, says Dr Ronald C. Kessler, Harvard’s most cited psychiatrist. 🧠 Mental health ≠ constant positivity 🌱 Stability, purpose & connection matter more #MentalHealth #HappinessMyth #Psychiatry #Harvard #Wellbeing

1/7 🧵BIG THREAD: The world's MOST cited researcher in Psychiatry & Psychology dropped an amazing Genomic Press Interview. Dr. Ronald C. Kessler (@HarvardMed) went from first-gen college kid dreaming of law → 1,300+ papers, 330k+ citations, reshaped global mental health policy via massive surveys in 30+ countries. His full story:

A 106-year-old woman who won her first swimming competition six years ago, a 107-year-old man who still holds a job, a chocolate-loving nun who lived to be 116 go.nature.com/49Zi9XB

Nossa pesquisa na Nature nature.com/articles/d4158… Nosso projeto com os centenários brasileiros está na Nature

🧵 THREAD 1/8 Nature just dropped a bombshell feature on Brazil's supercentenarians: people hitting 110+ without elite diets, gyms, or fancy meds. Their secret? Genes + insane resilience. And the groundbreaking research behind it? Published in your journal: Genomic Psychiatry @GenomPsychiatry!

🧵 THREAD 1/5 ONE YEAR STRONG! Just dropped my new editorial: "Year One: Genomic Psychiatry and the audacity of beginning" A year ago we launched into the unknown—some called it hubris, others ambition. But we bridged what was missing: paradigm-shifting science + real-world communication from genes to society Now? 6 powerhouse issues, 50+ editorial board legends (Nobel laureate included!), global media explosion (1,000+ outlets, 30+ languages, billions reached via AP & MSN.com).

🧵 THREAD 1/5 BREAKING from @GenomPsychiatry: The future of mental health research is HERE! Introducing "Genomic Psychiatry 2025: Entire Volume 1": Our revolutionary open-access e-book compiling a FULL YEAR of groundbreaking discoveries in psychiatric genomics. From genes to society, this 434-page powerhouse is FREE to everyone, everywhere!

At age 108, one of the Brazilian Supercentenarians works full time and his boss says he is his best employee! 🧠🧬 The Brazilian 🇧🇷 centenarians 🧓 are now featured in: Discover magazine: url.genomicpress.com/3xxc544d and Science Daily: url.genomicpress.com/2p85e6b7 Can we be productive at 108? Live to 120? Time will tell! (pun intended) Source: doi.org/10.61373/gp026…

🧵Breaking: Our latest Viewpoint in Genomic Psychiatry is going VIRAL! "Insights from Brazilian supercentenarians" reveals how Brazil's genetic admixture could unlock secrets to extreme longevity. Published TODAY, Jan 6, 2026. Already major news stories in Folha, Estadão, O Globo, & El País! 1/12

🧵 1/9 Exciting news! The November-December 2025 issue of Genomic Psychiatry (Vol 1, No 6) is now fully Open Access. Explore groundbreaking research on stress, epigenetics, brain aging, depression genetics, and more. Read it online in magazine format or download the entire issue as PDF.

8/9 New reality OTULIN sits at the ROOT of tau expression. Partial inhibition → lowers toxic phospho-tau in real Alzheimer’s neurons Total knockout → erases tau completely Brand-new, fully druggable target for Alzheimer’s, FTD, PSP, CBD…

I just published a paper in Genomic Psychiatry. We need more clinician-scientists. Let's shift the narrative of mental health to focus on the fundamentals like exercise, diet & sleep.

🧵 1/9 🧠THIS JUST BROKE THE INTERNET IN ALZHEIMER’S RESEARCH A brand-new paper (published 3 days ago) shows we had tau completely wrong. The enzyme **OTULIN** doesn’t just control inflammation… It CONTROLS WHETHER YOUR BRAIN EVEN MAKES TAU PROTEIN. Link: doi.org/10.61373/gp025…