Pietro Genovese

Epitope Editing Strategy Could Enable Less Toxic Stem Cell Transplants Ability to avoid pretransplant chemotherapy could open up #stemcelltransplants for patients who might otherwise be too sick or too high risk @Genovese_Lab @DanaFarber #epitopeediting hubs.li/Q04p1s5p0

🌟 #ICLE2026: Program Highlights Session 07: HSC Genetic Engineering and Epitope Editing 🎤 Chairs: Mario L. Squadrito (Italy) & Dirk Busch (Germany) @NaldiniLab @Genovese_Lab @CasiratiG Find out more: lnkd.in/dX7aRAAK #HSCEngineering #EpitopeEditing #GeneTherapy

Thrilled to see the great work from @danielevanbauer lab featured in @NatureBiotech! The discovery that a limited nucleotide pool in HSPCs constrains prime editing is a leap forward in gene editing technology. A huge shoutout to @SbastienLevesq4 and the entire team!

My postdoc work in the @danielevanbauer lab is out @NatureBiotech! We found that the limited nucleotide pool in hematopoietic stem and progenitor cells (HSPCs) constrains reverse transcription and thus prime editing (PE). nature.com/articles/s4158…

Very proud of your achievements @ferrari_sam93 !! It has been a privilege contributing in mentoring such amazing young scientist!

@adam_thiesen @andrea_csn @elonmusk Thanks @adam_thiesen for the great overview of our work!

I think I will start posting all my videos on X primarily. I hope you all put in more tools for video editing @elonmusk Here is a video about a recent Nature paper where base editing is used to protect myeloid cells during cancer treatment nature.com/articles/s4158…

@GENbio Thanks to @GENbio for covering our work in this excellent article!

Base Editing Tweaks HSC Epitopes for Targeted Immunotherapy Base editing of HSPC epitopes makes targeting genes key to leukemia survival possible, even if those genes are also expressed on HSPCs. Learn more: ow.ly/j9TF50PGbIc

@davidrliu @Nature Thank David. Glad you enjoyed our work, and thanks very much for having developed such powerful precision gene editing tools.

Casirati, Genovese et al. report in @Nature that base editing of epitopes in hematopoietic stem cells equips blood cells with the ability to evade CAR-T cells or antibodies, allowing the use of anti-leukemia drugs targeting epitopes that kill cancer cells, but previously could not be used because they would also kill healthy blood cells. Another elegant application of precision gene editing to enable otherwise impractical or unsafe therapeutic strategies. nature.com/articles/s4158…

Excited to share our latest publication about epitope editing in hematopoietic stem cells to enable targeted immunotherapy for acute myeloid leukemia. Congrats to @CasiratiG and all collaborators for this amazing work. nature.com/articles/s4158…

@ED_PhD_ Mongiove!! Great!

This time, our Employee Appreciation Month gift included a beach bag. I had to use it wisely! GU Medical Oncology, keep branding the world

Congrats to Zeng @Genovese_Lab @danielevanbauer et al. on their paper "Base Editing of Human Hematopoietic Stem Cells." Thanks for using #crispresso2! doi.org/10.1007/978-1-…

Gene editing stem cell transplants makes myeloid and T cell therapies safer, according to data at #ASH22 buff.ly/3hCEDqz

With #geneediting, researchers restored levels of CTLA-4 in T cells from patients with CTLA-4 insufficiency. In mice, they improved symptoms. ASGCT members involved: @RealDrfox, MbChB, PhD; Claire Booth, MBBS, PhD; Pietro Genovese @Genovese_Lab, PhD: ucl.ac.uk/news/2022/oct/….

@AlejoFraticelli Thanks Alejo, happy that you liked the work!

I just saw a crazy presentation at #ASH22 by the @Genovese_Lab… pretty close to finding a definitive cure for AML.

"Unless things change dramatically, the millions of people #CRISPR could save will never benefit from it. We must, and we can, build a world with #CRISPR for all." #healthjustice @igisci @nytimes nytimes.com/2022/12/09/opi…

eppro02.ativ.me/appinfo.php?pa… ready to share our exciting data tomorrow morning!🩸#ASH22

@PauFerrol @jcornlab @EJPRareDiseases Congrats Paula and all the team! Great work!

We had a dream….and it is a bit closer…Correct a mutation where it is happening,…still many steps to move it to patients but this is the first step!!!!Really greatful for an amazing collaboration with ⁦@jcornlab granted by ⁦@EJPRareDiseases⁩ nature.com/articles/s4146…

@BKleinstiver @NIH_CommonFund @NIHDirector @CGM_MGH @MGHPathology @MassGeneralNews @connorjtou @RachelSilvers11 @Christiano_RRA @FerreiraSilvaJ @ap_kanneganti @EmilyM_King @Linyuan79834832 @AnnSophieKroell Congrats Ben! Very well deserved!

Very humbled (and lucky!) to receive an @NIH_CommonFund @NIHDirector DP2 award. 🥉time was the charm. Grateful for this recognition that will allow my amazing lab members to continue pursuing their super interesting science. #CRISPR @CGM_MGH @MGHPathology @MassGeneralNews

Researchers at @SanRaffaeleMI, led by Dr. Maria Ester Bernardo, developed an MSC-based co-culture system to optimize the transplantation outcome of #CRISPR-Cas9 gene-edited human #hematopoietic stem and progenitor cells. 🧬 #OpenAccess | 🔗 bit.ly/3Cjn8mR

Finally out in @MolTherapy our new work showing that #mesenchymal stromal cells help "hand-in-hand" #CRISPR/Cas9 edited human #hematopoietic #stem cells to engraft. By Bernardo's lab in coll with @DiMiccoLab and @NaldiniLab. bit.ly/3A5LY71. Pic created with DALL·E 2.