Busch Group

Most GWAS data come from adults. An amazing new resource from Japan (JECS) offers GWAS data on 1,148 traits from a birth cohort of 80,638 children. The traits range from pregnancy and neonatal outcomes to childhood diseases, and serial lab work, and anthropometrics.

Just finished an inspiring symposium — a full day devoted to the hypothalamic–pituitary–gonadal (HPG) axis! Many thanks to Ken Ong (Cambridge) and Anders Juul (Copenhagen) for their insightful talks and to all participants for the stimulating discussions. @uni_muenster

Role of Genetics in the Age-Related Testosterone Decline in Men: A UK Biobank Study by Lynn Ogoniak @dralexbusch et al EJE Volume 193, Issue 2, August 2025 👉 doi.org/10.1093/ejendo… ESE Members free via 👉 my.ese-hormones.org #endocrinology #biobank #testosterone

Our work on sperm sequencing is now published! See below for: 🧑‍🔬Scientific tweetorial 📰 Accessible articles discussing implications for aging fathers [1/3] nature.com/articles/s4158…

🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much. Our new @NatureGenet including 9 disease and 7 biobanks shows: • Susceptibility variants ≠ survival • PRSs for onset weak at predicting survival • Lifespan PRS predicts survival better

🚀 New paper out: Using >22k @uk_biobank scans, we built a deep learning model that achieves human-level accuracy for testis segmentation — enabling the first population-scale studies of male reproductive health. 🔗 doi.org/10.1016/j.comp… #UKBiobank #MRI #DeepLearning

Gunnar from our lab joined @EYEScientists in Milano for the annual meeting presenting one of his projects on FSH action

Serum steroid metabolome in infancy 👶 Longitudinal LC–MS/MS in 189 healthy infants maps 16 hormones + enzyme activity. We deliver sex- & age-specific reference curves to support earlier diagnosis of steroidogen. disorders. tinyurl.com/mueu83vj @ESEndocrinology @TheEndoSociety

#CoMICWednesday #EJECoMICs Ep 60: NEW @EJEndo paper: Role of genetics in the age-related testosterone decline in men: a UK Biobank study youtu.be/s8LFo8RR8f0 Full article doi.org/10.1093/ejendo… By @SimbaComics led by @rahulsagu6 @ESEndocrinology

❓Why do some men lose testosterone faster with age? Our new study in Eur J Endocrinology shows: 🧬 Genetics explain baseline levels, ⚠️ But not age-related decline. 💥 Comorbidities like CVD & cancer matter more. 📖 doi.org/10.1093/ejendo… #Testosterone #MensHealth #UKBiobank

To the 23andMe Community, I am incredibly excited and humbled to share with you that TTAM Research Institute (TTAM), a new non—profit medical research organization that I founded and lead, has completed the acquisition of 23andMe.   I formed TTAM and pursued the acquisition of 23andMe because of my strong belief that everyone should continue to have the ability to learn about and benefit from their DNA, and that a non-profit structure is the best way to solidify our values and commitments to our customers, the scientific community and the world at large. Since its founding in 2006, 23andMe has stood for something revolutionary: that individuals should have a right to understand themselves at the most fundamental level — through their DNA.   Through their DNA they can understand their health risks , prevent disease and be true partners in participating in research that shapes the future of health and medicine. Understanding the code of life - our DNA - is one of the most exciting scientific missions of our lifetime.  Through our DNA, we can learn about our ancestry origins, prevent potential health issues, and help develop treatments that could benefit all of us.   Humans are 99.5% genetically identical, and we have DNA in common with everything alive today.  The pursuit to understand DNA will benefit all of us and all of life. That belief built one of the world’s most diverse and engaged genetic research communities. More than 15 million people have joined this journey, and over 80% have chosen to participate in research, contributing to over 275 peer-reviewed publications in cancer, cardiovascular disease, neurological disorders, and more.   These discoveries did not just stay academic - those discoveries were also translated into new genetic reports  for customers that helped them continue to learn about their own DNA.    Thank you to the 23andMe community that participated in research and contributed to discoveries that have had a meaningful impact for the world. I want to end on a personal note.   Over the last few years I unfortunately lost my father, my nephew and my sister.   These tragedies have sharpened my focus on what is most important to me and how I want to spend my time.   My passion is 23andMe.  The opportunity to give back to society with our research and help everyone benefit from learning about their genome with a healthier life, is a personal mission where I am dedicating my resources and my time.    We all have a disease or health condition that we care about .  By coming together as a single community, we are stronger and more powerful to make discoveries and to ultimately make a difference.   The future of healthcare belongs to all of us and it’s in our power to make a difference. I am honored to be back with 23andMe and look forward to sharing more with you in the weeks and years to come. With gratitude, Anne

Just wrapped up our presentation at #ENDO2025 We combined AI-based MRI segmentation with GWAS in nearly 19,000 men from the UK Biobank. A new way to study the trait — and a step forward in understanding male reproductive health. #MaleFertility #AIinMedicine #ENDO2025

Reversal of congenital #hypogonadotropic #hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation thelancet.com/journals/landi… #CHH #FREE to read

We have reached a sale agreement with @Regeneron, a leading US-based biotechnology company, to carry forward 23andMe’s mission and maintain customer privacy protections. Read more about today’s announcement here: 23and.me/3ZoX2JT

Indeed interesting, however, not even the FSHB locus replicates for M-ALL

Delighted to have been awarded an International Joint Project grant from @RoyalSocEd. This will fund 12 exchange visits between @EdinUni_IRR and @uni_muenster over the next 2 years. 👉 tinyurl.com/5n7fkvwa. Looking forward to enhancing 🏴󠁧󠁢󠁳󠁣󠁴󠁿 🇩🇪 collaborations @EdinUni_CRH 🕺💃

We are looking for you! To become a member of YARE is easy and gives you a lot of benefits. See the step-by-step below: •Easy peasy: use the registration form on the website, wait a few days (we do all manually!) and receive your certificate

I wrote about the latest attempt to sell genetic IQ prediction and why it is snake oil. A short 🧵: