Gut-Brain Science

📢What an amazing⭐️team @GutBrainScience‼️ Join the Crew #GutBrainScience, contact us 🙏 👋#ScienceTwitter #MedTwitter #GITwitter STAY TUNED!⚡️#Involve #Educate #Advance🔥 Thrilled to share our webpage🌱▶️gutbrainscience.org 🎯gutbrainscience.org/aim_mission.ht… gutbrainscience.org/about.html😇

New from our lab: Untreated maternal depression & early-life stress can rewire gut–brain circuits via enteric + sympathetic pathways, leading to long-term changes in gut motility & pain. 🔗 sciencedirect.com/science/articl… @karagm2009 @SarahANajjar @LinYungHung1

Honored to be selected for the 2026 Lefrançois-BioLegend Memorial Award from the American Association of Immunologists. @ImmunologyAAI Looking forward to presenting our work on Sensory Neuronal Regulation of Intestinal Inflammation and Immunity at #IMMUNOLOGY2026 in Boston.

Nice to see our recent Nature study highlighted in Gastroenterology. Thanks to the authors for the thoughtful perspective on how TRPV1⁺ sensory neurons and tuft cells coordinate intestinal type 2 immunity and the broader concept of neuro-epithelial sensory convergence.

Dive into our latest #GastroDigest in @AGA_Gastro🆕🔥 🚨From #Nociception to #GutImmunity: Neuro-epithelial TRPV1-Tuft cell circuit orchestrates #Type2Inflammation‼️ @AmerGastroAssn🙌 Anti #Helminth type 2 immunity👏 With Prof. Kara Margolis @karagm2009🙏😇 ⏩A blueprint for how neuronal sensory inputs shape epithelial differentiation & orchestrate tissue- & cell-specific immunity at barrier surfaces to control Th2-related gut immunity💡 🎯Clinically, neuro-epithelial circuits offer a mechanistic bridge between neural state & barrier immunity⏩Roadmap for neuro-immunomodulatory therapeutics that tune epithelial programs rather than broadly suppressing immunity💊🔥 📢Key takeaways: 🎯Activating TRPV1+ nociceptors ⬆️CGRP, enhances #tuft cell accumulation, ⬆️#goblet cell responses, & strengthens anti-helminth type 2 protection👏 🎯#Functional coupling between TRPV1+ neurons, tuft cells, & type 2 immunity✨ ⏩A detailed #map of TRPV1+ sensory convergence circuit🌟 👉gastrojournal.org/article/S0016-… 👉nature.com/articles/s4158… @AmCollegeGastro @my_ueg @ANMSociety @esnm_eu @GutBrainScience @unrmed @NYUPainResearch @MargolisLabNYU @RomeFoundation @RomeGastroPsych @BrainSinai @IcahnMountSinai @NatRevGastroHep @NGMJournal @IFFGD @INMAssociation @anma_i @ANGMA_AU @MRC_microbiome @GMFHx @TARGID_KULEUVEN

🆕🔥Adolescent normative intervals for #BodySurfaceGastricMapping‼️ 🎯#BSGM normative reference intervals support test interpretation & allow specific phenotyping of gastric abnormalities & guide symptoms management👏 👉onlinelibrary.wiley.com/doi/10.1111/nm… @ANMSociety @esnm_eu

🔔 Antibiotics induce profound changes to the gut microbiome. Even a single course of antibiotics has lasting effects up to 8 years later. 💊🦠 nature.com/articles/s4159…

Huge congratulations to PRC Associate Director Steve Davidson on securing an NIH R01 to investigate new targets for diabetic neuropathic pain! @restinpotential @karagm2009 @kenwardchan @Thomsen_Lab

@Nature @drdrcox @MaayanLevyPhD We identified a pathway linking microbial and metabolic changes in the gastrointestinal tract over the lifespan, peripheral inflammation, vagus nerve dysfunction, and reduced memory formation in the hippocampus. More details here: youtu.be/eUhY6KOZvOA

A single dose of antibiotics can have lasting effects on your gut microbiome, with changes that last well beyond 4 years. Three types of antibiotics stood out for their long term disruptive impact (3 at left, Figure) @NatureMedicine nature.com/articles/s4159…

Explore the most-read GI research shaping the field: ☑️ Top 15 basic science discoveries ☑️ Top 20 clinical research articles Read more: Basic: ow.ly/zqI250YrvwB Clinical: ow.ly/9cii50YrvwA @AGA_Gastro @AGA_CMGH @AGA_GHAdvances @AGA_TIGE @AGA_GHAdvances

What should clinicians really tell patients about diet? Workshops 3+4 of #GMFH2026 provide practical, patient-centered guidance on diet in IBS and cancer, from disease mechanisms to real-world dietary strategies in treatment. Join in and register now 👉 bit.ly/GMFH2026

Thank you so much to Stanford Medicine for highlighting our work. Great collaboration with Todd Coleman!

🆕🔥National Medical Expenditures Associated With #Pediatric #DGBI in 🇺🇸‼️ 🎯Potential importance of early detection & effective treatment for pediatric DGBI⏩Reduce public health & economic burden👏 @ANMSociety @esnm_eu 👉onlinelibrary.wiley.com/doi/10.1111/nm…

🆕🔥Alternative Pathways of #Acetylcholine Release in Colon: Role of #HighAffinity Choline Transporters‼️ 🎯High-affinity choline transporters provide a novel pathway for acetylcholine release originating from neuronal sources👏 @ANMSociety @esnm_eu 👉onlinelibrary.wiley.com/doi/10.1111/nm…

🆕🔥Central & peripheral #Neuromodulators in #FD & #Gastroparesis: Symptom-Based #ClinicalReview‼️ 🎯A pragmatic, symptom-oriented & mechanism-based approach facilitate individualized treatment selection & optimize clinical outcomes 👉onlinelibrary.wiley.com/doi/10.1111/nm… @ANMSociety @esnm_eu

📢Elegant study @AGA_Gastro @AmerGastroAssn 🆕🔥 🚨Intestinal Epithelial #Serotonin as a Novel Target for Treating #DGBI & #Mood‼️ @LinYungHung1 @karagm2009 @MargolisLabNYU @NYUPainResearch🎉 #GutConnectome🔁#BrainConnectome🧠#Serotonin #vagal pathway #SSRI ✳️The most recent advances into how the #GI tract modulates #EmotionalBehaviors ⏩A novel #gut-targeted therapeutic approach for mood modulation ⏩A new link in humans between in utero #SSRI exposure & #DGBI development👏 ▶️Targeted deletion of the #SERT in the intestinal epithelium reduced #anxiety & #depressive-like behaviors✨ ▶️Increased serotonin in the gut epithelium is #anxiolytic & anti-depressive which is mediated through #vagal signaling 🎯 ▶️Maternal #SSRI exposure is associated with a risk of developing #constipation in the first year of life⚡️ 👉gastrojournal.org/article/S0016-… @AmerGastroAssn @AmCollegeGastro @my_ueg @ANMSociety @esnm_eu @GutBrainScience @INMAssociation @RomeGastroPsych #GITwitter #MedTwitter #ScienceTwitter

🚀Don’t miss the upcoming @ANMSociety Basic Science Virtual Symposium: Basic science underlying drug development or clinical practice 👏 🗓️Wed, March 18, 2026 | 3:00 pm PT Moderators: @FaranakFattahi & @mgrover_gi Speakers: @SinghArashdeep & @JayPasrichaMD 🎯Transcriptome-guided #GLP-1 strategies in metabolic disease💡 🎯Gut-targeted therapies for visceral pain🔥 #Neurogastroenterology @GutBrainScience #TranslationalScience

Scientists have coined the term 'bacterial constipation' for a new disease caused by gut-drying bacteria Instead of focusing on nerve and muscle movement in the gut, the researchers examined the protective gel-like coating called colonic mucin: tinyurl.com/bp6s9nbn

🆕🔥#PercutaneousElectricalNerveFieldStimulation improves weight & other anthropometric outcomes in #Children & #Adolescents with #FunctionalDyspepsia who restrict their oral intake‼️ 🎯#PENFS can improve GI symptoms & #psychosocial outcomes #DGBIs👏 👉onlinelibrary.wiley.com/doi/10.1111/nm…

🆕🔥Preserved #AntralContractions measured by #WirelessMotilityCapsule are associated with 🔽response rates to G-POEM in #IdiopathicGastroparesis patients‼️ 🎯Diminished antral contractions & gastric emptying delay are more likely to respond to G-POEM👏 👉onlinelibrary.wiley.com/doi/10.1111/nm…