Hasanga Manikpurage

Wow!!! Many Thanks to @JeanetteErdmann, @konradtsawicki and @Circ_Gen for highlighting all the major points of our paper through this video!

📣New from Zamani et al! 📄Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets 🫀🧬 👉bit.ly/43bMPBU

Thank you to all colleagues involved in this project, supervised by Dr. S. Thériault. Thank you also to all scientists and participants involved in @_CARTaGENE_ , @clsa_elcv and Biobanque de l’@IUCPQ.

- CAD-PGS is associated with the extent of coronary artery damage observed. - In this study, not all CV-PGS are associated with the severity of CAD; lipid-PGS are.

📣 Clap de fin for my PhD work 🎬! The fourth and final article is now available in @CommsMedicine. We benchmarked a set of PGS for CV traits available from the @PGSCatalog resource in different Canadian cohorts🇨🇦. See more 👇🏽 - Link (OA): nature.com/articles/s4385… (1/5)

In patients with calcific aortic valve stenosis, lipoprotein(a) levels predict a higher risk of valvular and cardiovascular outcomes. #AHAJournals @HasangaDM @ClavelLabo @PPibarot @ArsenaultBenoit ahajrnls.org/4iqZYxj

2⃣Bridging genomics, transcriptomics, proteomics, and metabolomics In a rare combination of all 4 major omics layers, this study offers a great resource for dissecting the links between genetics, expression/slicing, molecular traits and disease risk 🔗nature.com/articles/s4158… 📊summ stats: intervalrna.org.uk/downloads/

The common IL6R p.Asp358Ala missense variant is associated with 5% ↓odds for CAD (inhibiting pathway validated & more inhibitors in RCTs), & 5% ↓odds for rheumatoid arthritis (w approved inhibitors for pathway). New study shows even greater (10% ↓odds) for AAA. ahajournals.org/doi/full/10.11…

Work supervised by Dr. Sébastien Thériault With many great contributors: @Jebou326, @egagnon_phd, @gobeil_emilie, @girard__arnaud, @YohanBosse, @ArsenaultBenoit and many others that don't have a twitter handle - From @IUCPQ, @universitelaval

Finally! Happy to share my 3rd PhD paper, now published in @ATHjournal! 🚀 This study explores the impact of integrating multiple independent lipid PRSs with a CAD-PRS for CAD incidence prediction in @uk_biobank. 👉🏽Link (Open Access! 📖): #fig5" target="_blank" rel="nofollow noopener">atherosclerosis-journal.com/article/S0021-…

Great collaborative work spearheaded by @DrMArdissino @aidanbutty showing that, among those sustaining early-onset myocardial infarction, a CAD polygenic risk score was the strongest among assessed predictors of recurrent events ahajournals.org/doi/10.1161/CI… @Circ_Gen

Lipoprotein(a) is an independent predictor for long-term in-stent restenosis and should be considered in the evaluation of patients undergoing PCI. academic.oup.com/eurjpc/article… @escardio @AboyansV @SilCastelletti @PeroneFrancesco @andreagallardo #cvprev

London -> Barcelona by train ✅ (surprisingly easy! 🚄) Just arrived for the 2024 @nextflowio Summit, very excited to be delivering the keynote tonight on this mildly intimidating stage (tech tests ✔️, Segrada Familia ✔️ … we’re ready to roll)

Probably the most important paper I will ever write link.springer.com/article/10.118… @stevesphd @BMCMedicine

The catalog of all possible SNVs altering existing upORFs or creating new ones (via both canonical  and non canonical TIS) in human transcripts is available on the mobidetails platform ( mobidetails.iurc.montp.inserm.fr/MD/) @soukarieh_omar @BPH_Research @univbordeaux_EN

Our new study published in @NatureComms, led by Ghislain Rocheleau and team. Using TOPMed WGS data, estimate heritability of CAD is 34%. Ultra-rare variants with low LD score contribute ~50% of the heritability. Enrichment in several functional processes. nature.com/articles/s4146…

>5000 Polygenic scores now available at PGSCatalog.org! As of today's release we've broken 5k PGS, indexing data from 673 unique publications. A big thank you to the authors submitting their data and our team in pursuit of #openscience, #FAIRdata, and reproducibility!

Fantastic @Nature News Feature by @AnilOza16- Why does heart disease affect so many young South Asians? Highlights our ambitious goals with @ourhealthstudy & others like @masala_study. nature.com/articles/d4158… 💜 ourhealthstudy.org 💜 @HeartDocSadiya @alka_kanaya @NammiKan