
Pankaj Garg
2.6K posts

Pankaj Garg
@HEARTinMagnet
Asso. Professor in Cardiology @UEA | Fellow @WellcomeTrust | Consultant Cardiologist @NNUH | #CMR #4DFlow #Echo #haemodynamics #HF 🇪🇺🇬🇧🇮🇳🌎🫀




















📄 4D-flow CMR meets diastology: can we finally assess E/e′ with MRI? 🔗 DOI: doi.org/10.1093/ehjimp… 🫀 Diastolic dysfunction (DD) is a key early marker of heart disease—but CMR has traditionally struggled to assess it. This study introduces a novel solution: 👉 CMR-derived 4D-flow E/e′ for biventricular diastolic function assessment ✨ What’s new? 👉 Combines: ✔ 4D-flow transvalvular velocity (E) ✔ CMR-derived tissue velocity (e′) ➡️ Recreating the classic echo parameter (E/e′) using MRI 📊 As shown in the graphical abstract (page 2): 👉 simultaneous evaluation of LV + RV diastolic function ✨ Study at a glance: 🔹 132 participants 75 healthy controls 57 CVD patients 🔹 Full biventricular assessment with 4D-flow + strain/annular motion ✨ Key findings: 📈 4D-E/e′ is higher in CVD patients ➡️ reflecting impaired relaxation 📊 Excellent diagnostic performance: ➡️ LV DD detection: AUC ~0.90 📌 Best method: 👉 annular velocity–based e′ 📉 Hidden disease uncovered: 👉 Among patients WITHOUT prior diastolic assessment: ➡️ 71% had abnormal LV diastolic function ➡️ 61% had abnormal RV diastolic function ⚠️ A major proportion of DD is currently missed in clinical practice 📊 Strong validation vs echocardiography: ✔ E velocity: r = 0.81 ✔ E/e′: r = 0.77 ➡️ As shown in Figure 3 (page 6): 👉 strong correlation with echo 🧠 Why this matters: 👉 CMR already performed in many patients ➡️ Now it can also provide: ✔ diastolic function assessment ✔ biventricular evaluation ✔ detection of early/subclinical disease ⚡ Key innovation: 👉 First robust demonstration of: integrated flow + tissue metric (4D-E/e′) using CMR ➡️ Overcomes limitations of: ❗ 2D flow ❗ static imaging planes 💡 Clinical take-home message: 👉 CMR is no longer “systolic-only” ✔ 4D-flow enables comprehensive haemodynamic assessment ✔ Can detect undiagnosed diastolic dysfunction 🚨 Bottom line: 4D-flow CMR brings echocardiographic E/e′ into MRI—unlocking a new era of full functional cardiac assessment. #Cardiology #CMR #4DFlow #DiastolicDysfunction #HeartFailure #CardiacImaging #EoverEprime #PrecisionMedicine #DigitalHealth 🫀📊













PCR Perspectives: Why is TAVI a different procedure in patient with pure aortic regurgitation? pcronline.com/Cases-resource… @jgranadacrf, Michael Borger and @joaolcavalcante discuss why aortic regurgitation requires a distinct approach during aortic stenosis, highlighting the importance of careful imaging and patient selection. #interventionalcardiology #PCRLV #TAVR








