HiBP-LeDucq

Latest paper from @HibpK on using uEVs to study the K switch Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter frontiersin.org/articles/10.33…

@AJPRenal @OHSUNews @dhekidney @JWNdothelium @XiaotongSu Congratulations, Ryan!

#COP9 signalosome deletion promotes renal injury and distal convoluted tubule remodeling Ryan J. Cornelius, Jonathan W. Nelson, Xiao-Tong Su, Chao-Ling Yang, and David H. Ellison 👀ow.ly/g2Qz50JT3AT #AJPRenal #JAB1 @OHSUNews @dhekidney @JWNdothelium @XiaotongSu

EDITORS PICK: Eplerenone caused natriuresis and potassium retention in mice lacking aldosterone, indicating that some kidney mineralocorticoid receptors are activated normally by glucocorticoid hormones rather than aldosterone @dhekidney @HibpK ahajrnls.org/3HFubXN

Congratulations, Xiao-Tong Su, for winning the #EB22 Phys Rep #Renal Section Abstract Award! "Uncovering Distal Convoluted Tubule (DCT) Heterogeneity with Enriched DCT Single-Nucleus RNA Sequencing" @XiaotongSu @APSPhysiology @physoc

Ryan Cornelius, Associate of LeDucq Potassium in Hypertension Network, in David Ellison’s Lab demonstrates that COP9 Signalosome controls the WNK4-NCC Pathway in the distal convoluted tubule, deletion mimics Familial Hyperkalemic Hypertension. FASEB J. 2022 PMID: 35552026.

frontiersin.org/article/10.338… Nice study from Mathias Kristensen, Robert Fenton in Søren Brandt Poulsen’s group providing support for the idea that thiazide sensitive renal sodium absorption in primary hyperaldosteronism is driven by hypokalemia rather than aldosterone

Congratulations to our own European Coordinator, Dr. Robert Fenton his award from the American Physiological Society, Renal Section @APSPhysiology of the 2022, Carl W. Gottschalk Distinguished Lecturer.

Network members, @DHEkidney and @PAWellingMD, describe a new paradigm of salt physiology in “Insights into Salt Handling and Blood Pressure” | NEJM nejm.org/doi/full/10.10…

@JASN_News The Leducq Potassium in Hypertension research network is proud to support this study lead by @rofe6065 and executed by the team. Team science!

September Highlights: Large-Scale Proteomic Assessment of Urinary Extracellular Vesicles Highlights Their Reliability in Reflecting Protein Changes in the Kidney This study assessed protein abundance in uEVs and kidney tissue isolated from rats bit.ly/j2020071035

Effect of Salt Substitution on Cardiovascular Events and Death | NEJM nejm.org/doi/full/10.10…

The aldosterone to renin ratio (ARR) in 871 Raine Study participants at age 17 and 758 at age 27 had sex-specific associations with BP. The ARR may help to assess hypertension in young people. @DrJunYang @marcus_schlaich @m_stowasser @moragjyoung ow.ly/Ve1U30rPjFT

#ArticlesInPress: Critical role of the #MineralocorticoidReceptor in aldosterone-dependent and aldosterone-independent regulation of #ENaC in the distal nephron" By: Viatcheslav Nesterov, et al ow.ly/cUah50FxrjT #AJPRenal #aldosterone

@__philipn__ @jbrianbyrd Both DASH and the quoted meta analysis show that potassium is most helpful when sodium intake is high. Look at figure 8 in the paper I cited.

Urinary extracellular vesicles can be isolated from urine and are a stable source of proteins. This study found that proteomic analysis of uEVs in rats reliably reflects protein changes in the kidney bit.ly/j2020071035 @PAWellingMD @RickGrimmPhD @SathishKMurali @dhekidney

Kortenoeven et al. show that hyperkalemia drives NCC ubiquitylation and degradation via a PP1α-dependent process facilitated by Hsp70 — @SUND_SDU @AarhusUni #PTM #hypertension Authors: @M_Kortenoeven @h_dimke @BrandtPoulsen @SathishKMurali @rofe6065 jbc.org/article/S0021-…

Very happy to see this in press - it has been a long road. High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter jbc.org/article/S0021-…

Mide tu presión arterial, contrólala y vive más ! cuida tus riñones #DiaMundialDeLaHipertensionArterial @ISNkidneycare

The LeDucq Network, Potassium in Hypertension, is happy to share a recent publication: Roles of WNK4 and SPAK in K+ mediated dephosphorylation of the sodium chloride cotransporter | American Journal of Physiology-Renal Physiology journals.physiology.org/doi/abs/10.115…

Leducq team reports sexual dimorphism of the Distal Convoluted Tubule in @AJPRenal, and captures the cover.