Blake Highet

For three years, my partner has been venting the same dinner-table monologue: "I can't find the anti-pTau again." "Someone aliquoted the GFAP and didn't write it down." "I think we have four tubes of the same antibody in four different freezers." She's a neuroscientist. I'm a builder. Eventually, I did something about it.

Effects of prolonged post-fixation on vascular biomarkers in postmortem human brains biorxiv.org/content/10.648… #biorxiv_neursci

I am hiring! If you enjoyed our recent publication (nature.com/articles/s4158…) and are interested in all things systems immunology, paediatric oncology and development, please apply below! Working in the wonderful @CRUK_CI and @Gilbertson_Lab cam.ac.uk/jobs/research-…

Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy, including postmortem PSP brain samples and a living human brain slice culture model nature.com/articles/s4159…

@joshleota Congrats Josh, you're on a roll!

Out today in PNAS, we explore how sleep habits – and nightly changes in sleep – may link to next-day physical activity. In two large-scale wearable sensor studies (~6.5 million nights from ~26,000 individuals), we found: 1. Longer sleep duration and later sleep timing were consistently linked to less next-day moderate-to-vigorous physical activity (MVPA). 2. Those who typically fell asleep at 9 p.m. logged ~28 more minutes of MVPA daily than those with a typical bedtime of 1 a.m. 3. The most active days followed nights when people went to bed earlier than usual without reducing their usual sleep duration. Key takeaway: Advancing sleep timing may be a simple, actionable way to support more active lifestyles without compromising sleep duration. Article link: pnas.org/cgi/doi/10.107… Proud to collaborate with @MonashUni, @WHOOP Research, @BrighamWomens, and @harvardmed, and grateful to brilliant co-authors Dr Mark Czeisler, Flora Le, Dr David Presby, Emily Capodilupo, Dr Hannah Scott, Dr Joshua Wiley, Prof Sean Drummond, Prof Shantha Rajaratnam, and Dr Elise Facer-Childs. @MarkCzeisler @DavidPresby @EmilyBreslow @1hannahscott @WileyResearch @smwrajaratnam @FacerChilds @MonashSleepLab @PNASNews

New study identifies the #hypothalamus as a deep brain stimulation target to promote walking recovery after #SpinalCordInjury in preclinical models and in a first-in-human feasibility study. #NeuroRehabilitation #Neuroscience #Neurotrauma @gcourtine nature.com/articles/s4159…

Happy to interrupt your election feed, to share our own findings. In an effort guided by @sophiejccaron and @JasonSynaptic we have made some interesting findings. Come and check it out.

A substantial reduction of #Alzheimers disease associated with semaglutide (Ozempic) in > 1 million people with Type 2 diabetes from a nationwide data resource alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

@JasonSynaptic @cziscience @MitaliTyagi2 Awesome to see this out! Congrats @MitaliTyagi2 and the rest of the team! 🥳

At the end of 2018 I was lucky to receive a @cziscience Ben Barres award. This preprint is the culmination of that funding, which allowed us to try "out of the box" ideas to study neurodegeneration. Fearlessly led by amazing student @MitaliTyagi2! 🧵 /1 biorxiv.org/content/10.110…

I think this should have been published in @NatureMedicine Good catch for @alzdemjournals😍 Title: *****Insufficient***** evidence for an association between iatrogenic Alzheimer's disease and cadaveric pituitary-derived growth hormone alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

@JamesWHalpin Well done

Job news klaxon 🚨📈 I’m now a Foreign News Reporter at The Sun. I’m incredibly lucky to be covering the biggest news stories in the world. Kiwi journos - please get in touch if you ever have something with UK or global interest (especially if it’s quirky!)

@DaniBeckman 🤯Is this FISH or IHC? Regardless, could you provide a no primary control or scrambled ISH probe control?

Not 👏Brain 👏Fog👏 This is a photo of a neuron exploding with #SARSCoV2. This is Brain Damage.

Our paper exploring the antibody labelling signature of neurofibrillary tangle maturity in Alzheimer's disease is out now in @alzdemjournals. doi.org/10.1002/alz.13…

@WilliamHCook @AdelHelmy79 @ml4cancer @ActaNeuro wow, that tumor is insane!

@JasonSynaptic @JunjieXu15 @AdamEzraCohen Congrats @JunjieXu15 ! Looking forward to seeing all the amazing things you're going to achieve in the future!

Bitter sweet day..but mostly a celebration of an amazing student @JunjieXu15! We will miss him as he moves on to the @AdamEzraCohen’s lab. Congrats Junjie!

This was quite fun to co-write! New review on retrotransposons and endogenous retroviruses in neurodegenerative disorders from @joshdubnau and yours truly: go.shr.lc/3wcE0Ls

@JamieManning_ Congratulations Jamie!

Congratulations to Hao, Qing, and all other authors! Very happy to have played my small part in this work.

I'm delighted to share the latest work from our lab in which @HaoChingJiang1 and SungJin Park demonstrate that MS4A1/CD20 functions as a mammalian odorant receptor in a previously uncharacterized population of sensory neurons. rdcu.be/dE8B7

Since our lab tech Alyson is moving on to grad school (🎉), we are in need of a new tech. We are especially interested in folks who have tissue culture experience as the duties will be to generate primary rodent neurons. Please RT and DM me if interested. utah.peopleadmin.com/postings/161577

@Michael_Xupb Congratulations Peibo!

Happy to share that my second PhD work is online now! I am honored to be the co-first and co-corresponding author of this project. TL;DR, we established a multiplexed method to simultaneously capture single-neuron transcriptome and projectome. (1/n)