Jonathan He retweetledi
Jonathan He
3.9K posts
Jonathan He
@HoustonArsenal
Pathologist | Past AP/CP & co-chief resident @UTSW_Pathology; Surg path fellow @BWHPath; Dermpath fellow @MDAndersonNe | Opinions are mine
Dallas, TX Katılım Şubat 2011
1.4K Takip Edilen1.2K Takipçiler
Jonathan He retweetledi
I am looking for cases of colorectal "invasive stratified mucin-producing carcinoma." This is analogous to the cervix lesion and is the invasive counterpart of SMILE. If you have a case, please contact me! Pics from PMC10585790 (free online) #pathology #PathTwitter #PathX #gipath
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Jonathan He retweetledi
Molecular Genetic Alterations in selected breast tumors.
#breastpath #molpath
@smlungpathguy @JMGardnerMD @jennpincus @ADamronMD @nucleololailo @TheISBP @thejourneymate @nusrat_xahra @ariella8 @jaimearturomc @ariella8 @atman_ci @pepeheffernan @Callie_Tor @junu_devi @Komalgang
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Jonathan He retweetledi
I am pleased to share our findings on the role of the NLRC4 inflammasome in the pathogenesis of MDS. doi.org/10.1182/blooda… I look forward to building on these findings and continuing to advance our understanding of CHIP, CCUS, and overt myeloid malignancies.
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Jonathan He retweetledi
Join us on Wednesday, August 26 at 12:00 p.m. Central for the Young Physicians' Committee’s second annual webinar, “Unscripted Dermpath: What No One Tells You.”
Learn more and register at asdp.org/YPCwebinar
#DermpathSurvivalGuide #DermpathUnfiltered
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Jonathan He retweetledi
Guess the Arsenal player who wore shirt number 7 from 2006 to 2016
Level: HARD
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Jonathan He retweetledi
This is an anti–PD-1 inhibitor–induced squamoproliferative eruption (KA/SCC spectrum) 2/2 pembrolizumab.
DDx: Hypertrophic actinic keratoses, hypertrophic lichen planus, prurigo nodularis, cutaneous melanoma metastases.
Biopsies from the scalp, wrist, & forearm demonstrated moderately differentiated SCCs, consistent with an anti–PD-1 inhibitor–induced squamoproliferative eruption. Pembrolizumab was discontinued, and the lesions were treated w/ a combo of surgical excision, cryotherapy, & acitretin, resulting in complete clearance after approximately 8 weeks of acitretin.
Surveillance imaging has remained -ve for melanoma recurrence. Although uncommon, anti–PD-1 inhibitors can paradoxically induce eruptive keratoacanthomatous & SCC-like proliferations, particularly in older patients, & management depends on severity, ranging from local destructive therapy to systemic retinoids & discontinuation of immunotherapy in extensive disease.
Scott C. Howard@schowardjd
A man in his 80s w/ stage IIIC BRAF WT melanoma developed severe generalized pruritus after cycle 2 of pembrolizumab (200 mg q3wk), followed after cycle 5 by multiple hyperkeratotic papules, nodules, & plaques on an erythematous base involving the extremities, w/ linear keratotic papules on the palms. He was not receiving BRAF/MEK inhibitors and had no significant UV exposure. PMHx included stable oral LP, HTN, T2DM, & BPH. What’s the diagnosis❔
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Jonathan He retweetledi
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Jonathan He retweetledi
What Histologic Features Predict Mismatch Repair Deficiency in Endometrial Endometrioid Carcinoma?
Delighted to share this article, recently published in Pathology - Research & Practice, led by Drs. Marketkar and Caindec @BrownPathology. Our investigation demonstrates that routine histopathologic evaluation can help identify tumors likely to harbor MLH1/PMS2 deficiency. Five morphologic features were evaluated: microacinar architecture, intraluminal acute inflammation, intraluminal necrosis, extraluminal acute inflammation, and a dense peritumoral lymphoid response. The presence of three or more of these features predicted MMR deficiency with an 80.6% positive predictive value and 85% specificity, with moderate interobserver agreement. These findings support a practical, cost-effective approach for triaging cases for MMR testing, particularly in resource-limited settings where universal testing may not be feasible.
Honored to be part of this study!
Free full-text access:
authors.elsevier.com/c/1nIca1EEMT-L…
Journal article:
sciencedirect.com/science/articl…
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@scrapytweets From Team Gabriel to Team Martin thanks to Real Sociedad
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@AlrahwanDavidMD @carina_dehner This new entity first described by Bouvier et al, frequently harbors THBS1-ADGRF5 fusion.
pubmed.ncbi.nlm.nih.gov/32047233/
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@AlrahwanDavidMD Diffuse CD34+, ERG+ but usually a bit weaker than the endothelial cells. EMA+ (multifocal) is a bit interesting for this case, but can be seen in ACFMT (2/16 in @carina_dehner 's case series).
pubmed.ncbi.nlm.nih.gov/39181449/
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@AliAlzughbi Didn't do, but in this case, both should have been negative
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