Hugo Almarza Salazar

.@PriyaChauhan97, Yogita Phogat, @MahakSharma23 et al. report that the small GTP-binding protein Arl8b recruits the Rab11a GAP, TBC1D9B, to inactivate Rab11a-mediated recycling of newly synthesized LAMP1 and mediate its efficient sorting to #lysosomes. hubs.la/Q04hwGWk0

Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons | Science Advances science.org/doi/10.1126/sc…

Explore recent advances related to #lysosomes, focusing on their maintenance, regulation, and relevance to human health and biology. Studies include how lysosomes are maintained by ion channels & how homocysteine inhibits lysosomal V-ATPase function. 👉 hubs.la/Q04gcNcw0

In situ cryo-ET defines the ultrastructure of ER exit sites in human cells | Nature Cell Biology nature.com/articles/s4155…

Revised : ATG2A interacts with RAB1A and ARFGAP1 positive membranes during autophagosome biogenesis | bioRxiv biorxiv.org/content/10.110…

Chandramouli Mukherjee @MukherjeeCm_02, Bhavani Shankar Sahu @urssahu @DBT_NBRC and colleagues find that Chromogranin B plays an essential role in post-ER sorting of dense-core vesicle cargo. journals.biologists.com/jcs/article/13…

ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis: Neuron cell.com/neuron/fulltex…

Autophagy modulation in cancer nature.com/articles/s4157… rdcu.be/fjmxZ This new Review discusses the promise and limitations of targeting autophagy to limit malignant transformation, exacerbate cancer cell death driven by conventional drugs and restore immunosurveillance

Lan Yang et al. @zje_institute develop a light-based tool to precisely modulate astrocytic Ca²⁺ signals via endogenous IP3Rs, revealing how local vs global Ca²⁺ patterns differentially control organelle transport and #astrocyte #morphogenesis. hubs.la/Q04h7Vy70

Wang et al. perform high-res, long-term live-cell imaging in #Neurospora crassa to visualize #circadian clock proteins at endogenous levels, revealing how subcellular organization & internuclear communication coordinate timing in a multinucleated syncytium hubs.la/Q04h816b0

In the latest issue! The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis dlvr.it/TSccbf

A new paper in @SciSignal visualizes the delicate ebb and flow of receptors within neurons via the unusual process of transcytosis—helping answer how these cells maintain their function and connectivity in vivo despite their spindly, elongated nature. scim.ag/4dm8OLu

Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer’s disease pathology nature.com/articles/s4358…

EMBO Practical Course on Developmental Biology: From Cells to Neural Systems 🗓️ 07 al 20 de enero de 2027 📍Quintay-Chile

Carta abierta Ciencia, conocimiento y medio ambiente: bienes que Chile no puede sacrificar

Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy dlvr.it/THpFZ2

The Uvrag-containing PI3K complex promotes Hsc70-4 dependent endosomal clathrin removal and lysosomal maturation in Drosophila nephrocytes biorxiv.org/content/10.648…

Perinuclear Actin Airbag Protects the Nucleus from Shock: Biophysical Journal cell.com/biophysj/fullt…

MitoSafe hypothesis: safeguarding mitochondrial morphology and innate immunity dlvr.it/TSXft0

Spotlight: new work from Zhao et al. (hubs.la/Q04gBKv50) establishes a direct link between PI(3)P and #actin in mitochondrial dynamics. Sneha Hegde and Marc Germain @UQTR discuss the findings: hubs.la/Q04gBDpc0 #Mitochondria #Lipids