Jing Hu

@JudithAgudo1 @nyscf @parkerici @Nature Congratulations Judith!

Metastasis kills most cancer patients and grows from invisible seeds. How do these seeds escape from attack by immune cells? These seeds harness stress hormones!🤯 ⁦thanks to ⁦@nyscf⁩ ⁦@parkerici⁩ for their support. Today at ⁦@Nature⁩ nature.com/articles/s4158…

@KarunaMDPhD @CancerGrand @CR_UK @theNCI @BowelbabeF Congrats Karuna!!

Excited to be awarded a Cancer Grand Challenge grant as part of team REWIRE-CAN to develop new approaches to combat cancer #plasticity. Our goal: to see all #colorectalcancer patients become colorectal cancer survivors. Thank you @cancergrand @CR_UK @theNCI @BowelbabeF Yosemite!

@TuomasTammela Nice work! Congrats Tuomas and team!

Paper out! In this study we show a malignant cell state with features of an epithelial injury-associated regenerative state drives conversion of premalignant lesions to malignancy and progression & drug resistance in advanced cancers. rdcu.be/eZ7g5

@aliceyting Congratulations Alice and team! Happy to see this story out!!

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time fluorescence to modulation of innate cell behavior (excitation or inhibition of neurons, induction of cell migration, etc.)? Today we report in Nature a new technology platform that provides a step in that direction: PAGERs, for Programmable Antigen-gated G protein-coupled Engineered Receptors, convert recognition of extracellular soluble or cell-attached antigens into diverse user-selected responses. PAGERs are based on G-protein coupled receptors (GPCRs), which themselves are not structurally modular, but we were able to build in modular antigen gating by fusing an antagonist peptide to the extracellular N-terminal end, and then gating the antagonist with a fused antigen-binding nanobody.  When antigen binds, it sterically interferes with the antagonist, leading to relief of receptor inhibition. Drug or agonist can then turn on PAGER. nature.com/articles/s4158…

@TuomasTammela @Xueqian_Zhuang @Nature Congratulations Tuomas and Xueqian! Happy to see this work out!!

Several years in the making (and aging), @Xueqian_Zhuang 's study on aging is out today @Nature. She finds, surprisingly, that aging suppresses tumorigenesis and stemness in the lung by promoting a functional iron insufficiency in the alveolar epithelium. nature.com/articles/s4158…

@obenaufa @Nature @AnaisElewaut @guillemxtivill Congratulations Anna, great work!!

So excited to share our new paper out in @Nature led by the fabulous @AnaisElewaut and @guillemxtivill providing mechanistic insights into anti-tumor immunity and why it may fail in so many patients! Sky-torial on @obenaufa.bsky.social rdcu.be/d1F7s

@KarunaMDPhD @Nature @andrewrmoorman @elliebenitez11 @f_cambuli @KarunaGaneshLab @Dana_Per Congratulations Karuna!!!

Thrilled to share our paper now out @Nature delineating #plasticity during #CRC #metastasis, a fantastic collaboration led by @andrewrmoorman @elliebenitez11, and @f_cambuli from the @KarunaGaneshLab and @dana_per lab! nature.com/articles/s4158… rdcu.be/dYAVK. A 🧵

@JAguirreGhiso @CellCellPress Congratulations on this amazing work!

@TuomasTammela @AnupriyaSingha9 Congratulations Tuomas & team!!

Paper out!📢 @AnupriyaSingha9 and #HannahStyers from the lab find acute resistance to targeting KRAS in pancreas cancer is surprisingly driven by a classical epithelial state. Co-targeting classical cells and KRAS augments response - clinically important! aacrjournals.org/cancerdiscover…

@TuomasTammela Congrats Tuomas, Xueqian and the team!

Excited to share our newest pre-print by Xueqian Zhuang on how aging suppresses tumorigenesis and stemness in the lung by promoting a functional iron insufficiency in the alveolar epithelium. Interestingly, this renders aged cells resistant to ferroptosis: biorxiv.org/content/10.110…

The phrase ‘metastasis accounts for 90% of cancer deaths’ is one of the most widely used in cancer research, yet it is overly simplistic & imprecise. Here we dig deeper into the events leading to cancer mortality nature.com/articles/s4156… 1/2

@megeblad Congratulations Mikala! Also thank you for giving such an exciting talk and for the inspiring discussions.

It is such an honor to receive the Fidler innovation award from the MRS. The work the society is doing to engage early stage career scientists, involve patient advocates, and drive progress towards preventing and treating metastasis is very inspiring. Thank you very much!

@MetastasisRS @KarunaMDPhD Congratulations!

Congratulations to @KarunaMDPhD, who was awarded the MRS Sue Eccles Early Career Investigator Award at this years biennial congress. #MRS2024

@ScientistBecs @ImmunityCP @SunLab_Official Congrats Bec! Beautiful work!

Thrilled to have this story out online @ImmunityCP!! Together with @SunLab_Official, we highlight how dietary fasting improves NK cell anti-tumor immunity and examine the tissue-specific processes that drive these improved responses 🧵cell.com/immunity/fullt…

NEW Viewpoint! We asked 6 experts, @JAguirreGhiso, @alpcorreia, @JudithAgudo1, C. Klein, L. Chodosh, M. Bhatia to share their opinions on the current state of dormancy research and the challenges associated with translating new findings into the clinic. nature.com/articles/s4156…

Thanks to @NatureCancer for inviting me to share my experience of becoming an independent PI! Also thanks to my mentors, colleagues and lab members for the great support. We are ready for the exciting journey ahead!

Thanks to the Metastasis Research Society for selecting our study on dormant metastasis in the #YearofMetastasis highlights! @LabMassague @Nature

@KarunaMDPhD @KarunaGaneshLab @MSKCancerCenter Congratulations Karuna!

Excited and honored to receive this award! Thank you to all the amazing people in @KarunaGaneshLab @MSKCancerCenter, mentors, collaborators, patients and funders for enabling us to do impactful science. #plasticity #colorectalcancer #metastasis

@TuomasTammela Congratulations!

I am excited to share the lab's first preprint! We show that a lung cancer cell still remembers what its cell of origin, the AT2 cell, was supposed to do upon loss of KRAS activity - make alveolar epithelium. Mechanism seems to be conserved in patients. biorxiv.org/content/10.110…

@endicytosis Congratulations!