ImmunoKevin - Kevin Gao

You can read our new study, out now in @JCI_Insight! (tinyurl.com/4bjcraeu) We examine how expression of a STING gain-of-function (GOF) mutation in radioresistant host cells results in the development of lymphocyte autoimmunity. Some highlights from our study: (1/7)

#InterferonsFriendsOrFoes?! @labs_mann @NordmannThierry French Ji &co using single cell proteomics identify @Nature an IFN signature in macrophages & keratinocytes KCs in a fatal #skin disease showing that JAK inhibition prevents KC death, curing patients nature.com/articles/s4158…

@Mingqi7up @NatImmunol @FitzgeraldKate congratulations, Mingqi!

nature.com/articles/s4159… I hope this is a helpful review! Appreciate the opportunity to co-write this review in @NatImmunol with my mentor @FitzgeraldKate. Thanks to all the reviewers' comments which significantly elevated our work and thanks to the unsung artists for their art!

1/ We are excited to share a simple yet powerful whole blood assay to detect human type I interferon (IFN) deficiency...

@tse_elegans @ImmunityCP @CellReports congratulations Sammy!!!

Stoked to share our companion stories, now out in @ImmunityCP and @CellReports! We characterize an enzymatic TIR protein as an immune sensor in animals, showing that it is a guard protein in an effector-triggered immune response. cell.com/immunity/fullt… cell.com/cell-reports/f… 1/

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults biorxiv.org/cgi/content/sh… #biorxiv_immuno

An autoinflammatory syndrome-associated STING mutation supports formation of germinal centers containing immunocompetent cells in the lungs of irradiated mice following BMT- insight.jci.org/articles/view/… Study from@ImmunoKevin and colleagues @kchianggg @FitzgeraldKate @UMassChanPII

Innate immune responses against mRNA vaccine promote cellular immunity through IFN-β at the injection site nature.com/articles/s4146…

An evolutionary perspective to innate antiviral immunity in animals dlvr.it/TCRyJD

Our paper introducing the concept of 'defensive tolerance' officially came out in @jclinicalinvest. I would like to thank all our collaborators, as well as Drs. Molinari and Cravedi for their wonderful accompanying commentary. #defensivetolerance jci.org/articles/view/…

Lastly, thank you to my thesis advisors Drs. @FitzgeraldKate and Ann Rothstein. Ecstatic to see this piece of my thesis work finally published.

I also want to acknowledge Dr. Kerstin Nundel, who not only contributed to this study but has also been a constant and amazing mentor throughout my PhD training. Thank you also to our collaborators, Dr. PJ Utz and Xihui Yin for their generous help and support.

You can read our new study, out now in @JCI_Insight! (tinyurl.com/4bjcraeu) We examine how expression of a STING gain-of-function (GOF) mutation in radioresistant host cells results in the development of lymphocyte autoimmunity. Some highlights from our study: (1/7)