Inês Chen

Out @MolecularCell from Schulman group @StJudeResearch & @MPI_Biochem: E3 Ub ligase CRL2-KHLDC2 uses a kinetic mechanism and auto-inhibitory self-assembly to avoid targeting non-substrate proteins with degron-like sequence. authors.elsevier.com/a/1gbyX3vVUPNx…

We look forward to welcoming our guest speakers in person at St. Jude next Monday for the Symposium! #structuralbiology #crystallography #NMR #cryoEM #cryoET #MDSims #HybridMethods #MachineLearning #ComputationalStructuralBiology #IntegrativeStructuralBiology

Work from @TheBlanchardLab and @WilsonLab2 combines #smFRET and #cryoEM to reveal the mechanism of action of antimicrobial peptide argyrin: ArgB binds EF-G on ribosome and inhibits conformational changes required for translocation and EF-G dissociation. pnas.org/doi/full/10.10…

Now out @NatureChemistry: work from @TanjaMittag lab in collaboration with @PappulabWashU deciphers the rules in the stickers-and-spacers model that govern phase separation by prion-like low-complexity domains. nature.com/articles/s4155…

Out in @CD_AACR: by integrating biophysics, cellular imaging and transcriptomics, Kriwacki, Mullighan & colleagues demonstrate the role of LLPS in leukemogenesis by NUP98 fusion oncoproteins and identify the specific molecular interactions involved. cancerdiscovery.aacrjournals.org/content/early/…

Hi-res ssNMR illuminates structures of antifungal AmB “sponges” consisting of asymmetric head-to-tail homodimers staggered in a clathrate-like lattice with large void volumes similar to the size of sterols. @TarasPogorelov @nmrfam @Illinois_Alma @UWMadison nature.com/articles/s4159…

Today with @emblebi we’re expanding the #AlphaFold Protein Structure Database to cover UniProtKB/Swiss-Prot (of @uniprot). This includes key proteins of interest that have been manually curated by experts & will more than double the database size to >800k! dpmd.ai/alphafolddb