Intestinal Cell News

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A new study has identified NAT10, an #RNAAcetyltransferase that regulates mRNA stability, as a driver of #ColorectalCancer progression by stabilizing CDK4 mRNA through ac⁴C modification, promoting cell-cycle progression and tumor growth. 📑 Learn more: bit.ly/3Pg0oxd

A meta-analysis performed by the lab of Dr. Ana Melo at @MethodistHosp has shown that #HER2 expression often differs between primary and metastatic gastric cancers, highlighting the importance of reassessing HER2 status in metastatic lesions to guide targeted therapy. Learn more: bit.ly/4wHeZm7

A recent study reveals that Candida albicans cooperates with Fusobacterium nucleatum to drive #ColorectalCancer progression through a Flo9–RadD interaction. Discover more at @Cancer_Cell: 🔖 bit.ly/3RFaKqY

A recent study shows that cannabidiol promotes intestinal stem cell regeneration after radiation injury by activating fatty acid β-oxidation. Learn more here: 🔖 go.nature.com/3R13ntT

Investigators led by Drs. Frederic J. de Sauvage and Robert Piskol reveal a metastatic cell state in #ColorectalCancer driven by high MAPK and low WNT signaling. Learn more here: 🔖 go.nature.com/48RB7A0

Researchers from Fudan University show that HERC2-mediated ubiquitination of DDX21 drives a dormancy-like, radio-resistant state in #ColorectalCancer through the NUCKS1–p21/p27 axis. 🔖 go.nature.com/3P9Mo87

📢 New in @cddpress! SEL1L3 suppresses #ColorectalCancer growth and migration by inhibiting HRD1-mediated #EndoplasmicReticulum protein degradation and stabilizing the tumor suppressor STING. Learn more: go.nature.com/3Ps6pXy

Researchers at the Guangdong Institute of Gastroenterology have identified the CLK1–Hippo/YAP–CXCL1 signaling pathway as a driver of immune suppression in #ColorectalCancer and shown that targeting CLK1 can improve responses to anti–PD-1 immunotherapy. 🧾 Read the study in @CIR_AACR: bit.ly/4upjIGU

📢 New in @SciReports! Sulfurized #garlic alleviates ulcerative #colitis by inhibiting ferroptosis and restoring intestinal barrier function via activation of the Keap1/Nrf2/GPX4 antioxidant pathway. 🧄 Read the study: go.nature.com/4cThUQS

New research from Chinese researchers shows that exhausted CD8+ T cells promote the progression of #ColonAdenomas to cancer by activating RUNX2 in epithelial cells. This suggests that RUNX2 may be a potential therapeutic target for treatment of the disease. 💊 🗒️ Read the paper in @cddpress: go.nature.com/4d1xZ5P

Researchers from @UofT alongside Dr. Dana Philpott show that NOD2 sensing of microbiota drives fetal-like reprogramming of intestinal epithelial cells, promoting regeneration after injury. Learn more via @PNASNews: 🔖 bit.ly/4elQzba

Serotonylation drives ferroptosis resistance! Researchers show that TGM2-mediated GPX4 serotonylation promotes gastric cancer by ⛔ blocking ferroptosis. 📝 go.nature.com/4ePUa18

A regulatory layer in cancer progression. Researchers found that SLC1A3 is significantly overexpressed in colorectal cancer tissues compared to adjacent normal tissues, and elevated SLC1A3 expression is associated with poor prognosis. 💡 bit.ly/3Ovnm31

A metabolic driver of tumor progression! 🔬 Researchers show that the aspartate transporter SLC1A3 drives #ColorectalCancer growth and immune evasion via the MDM2–p53 pathway and M2 macrophage polarization. 📕 bit.ly/3Ovnm31

Researchers show that METTL3 drives colorectal cancer progression by stabilizing MALAT1 via m6A modification, activating NF-κB signaling and tumor growth. bit.ly/4t5J0cd

In this @Nature study, Dr. @MagarianBlander and colleagues at @WeillCornell identify CASP5C as a novel amplifier of Wnt signaling that promotes intestinal epithelial renewal by cleaving APC and sustaining cell proliferation. Discover more here: 🔖 go.nature.com/4tzbGLP

The AGA has announced the selection of 84 recipients to receive $2.9 million in research funding through the annual AGA Research Foundation Awards Program. Learn more via @AmerGastroAssn 📰 bit.ly/4d1O8ZZ

Researchers at the Karolinska Institutet alongside Dr. Sylvain Peuget show that bacterial LPS from Klebsiella pneumoniae promotes chemoresistance in #ColorectalCancer by suppressing p53 via stromal signaling in the tumor microenvironment. 🔖 go.nature.com/4u3CWSt

Researchers show that Cya-Gly-Fer significantly inhibits colorectal cancer tumor growth and metastasis. Discover more here at @iScience_CP: 📘 bit.ly/41KbIEs