Connor Dobson
1.1K posts
Connor Dobson
@ItsVirusTime
Bioengineering to unlock new possibilities | Formerly PhD @MITdeptofBE (Birnbaum Lab) with a minor (major) virus obsession
Cambridge, MA Katılım Ekim 2011
742 Takip Edilen527 Takipçiler
Hey DC, who has the best steak and cheese in the city?
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It’s hard not to get addicted to this.
From side conversations with @MEBirnbaum to an incredible result for patients. So proud of the Kelonia team for all the hard work it took to make this real.
KeloniaTx@KeloniaTx
Next month at #ASH25, we will present first-in-human data of KLN-1010, our novel in vivo CAR-T therapy, from our ongoing Ph 1 inMMyCAR study in a late-breaking oral session. keloniatx.com/kelonia-therap…
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These are the days that make the long hours worth it. Excited to see a technology I invented take this big step toward benefitting patients.
Grateful to the whole team at Kelonia for building what was once just cool tech into a real drug that could bring CAR-T to everyone.
KeloniaTx@KeloniaTx
The first patient with multiple myeloma has been dosed in the inMMyCAR study, our first in-human Ph 1 clinical trial of our in vivo gene therapy, KLN-1010. Learn more about the inMMyCAR clinical trial and our unique gene delivery platform: keloniatx.com/kelonia-therap…
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Excited to see some movement on understanding the human thymus, and for everything @BrookeHuisman will build on from here 🚀
Brooke Huisman@BrookeHuisman
Thrilled to share our study, online today @ImmunityCP : thymic mimetic cells are evolutionarily ancient, with conserved and species-specific elements in humans, zebrafish, and mice. cell.com/immunity/abstr… 1/n
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Connor Dobson retweetledi
Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells biorxiv.org/cgi/content/sh… #biorxiv_immuno
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Connor Dobson retweetledi
Um..🤯. Freeze dried tissue preserves chromatin for centuries!
“…we dehydrated the tissue first. The architecture was fine….Ran over it with a car, had a former Astros starting pitcher throw a fastball at it, fired a shotgun at it. Still fine.”
Juan A. Rodríguez@jrotwitguez
It’s finally out! 🥳 Today @cellcellpress we report non-mineral fossils of ancient chromosomes in skin from a woolly mammoth that died in Siberia, 52,000 years ago. 🦣💨 Don’t miss our thread below! 🧵👇🏽
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Lots of good answers to this, but for me it has to be high-quality single-molecule protein sequencing methods. From basic science to the clinic, there’s so much we could learn from knowing what’s going on at the protein level in and out of cells
Patrick Hsu@pdhsu
15 years ago, we didn't have AI, single cell, CRISPR, RNA tech, or broad delivery tech (LNP, VLP, etc.) All of these will continue to mature and advance, but... What will be the biggest biotechnologies 15 years from now?
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@UrnovFyodor @Oncology_at_AZ @statnews I believe it was expression a dominant negative TGFBRII. A little bit of detail in slide 14 (from AACR 2023) here: astrazeneca.com/content/dam/az…
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Could a kind human tell me how the CAR-T was armored in the @Oncology_at_AZ program just described at the #ASCO24 ?
Passage from @statnews @angRchenh.
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It’s been really cool to see the confluence of technology development and molecular insights that have enabled such detailed studies of viral molecules directly on viruses, performed safely and efficiently. Can’t wait for future progress in this space
Bloom Lab@jbloom_lab
In new study led by @bdadonaite, we measure how all mutations to H5 influenza HA affect four molecular phenotypes relevant to pandemic risk: biorxiv.org/content/10.110… Results can inform surveillance of ongoing evolution of H5N1.
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Connor Dobson retweetledi
Excited to share some of my PhD work was pre-printed! Using single-cell sequencing, we took a deep look at a library of CAR signaling architectures to try to identify signal-intrinsic drivers of CAR-T function🧵👇 @MEBirnbaum @kochinstitute @MITdeptofBE
biorxiv.org/content/10.110…
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Connor Dobson retweetledi
Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence biorxiv.org/cgi/content/sh… #biorxiv_immuno
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Connor Dobson retweetledi
Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastoma biorxiv.org/cgi/content/sh… #biorxiv_immuno
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Big day for the team!
KeloniaTx@KeloniaTx
We’ve entered into a #research collaboration and #license agreement with Astellas Pharma subsidiary, Xyphos Biosciences, to develop innovative universal, off-the-shelf in vivo #CART #celltherapies for cancer. Learn more: keloniatx.com/astellas-and-k… #biotech
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Connor Dobson retweetledi
There’s a frequent perception among recent entrants to drug discovery world that if we could just find drug candidates faster, this will be a useful accelerant to the overall process. The issue is: this thinking is mostly (but not entirely) incorrect. 🧵 1/
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@Mykalt45 2 main theories have always stuck out to me:
1) There’s a T cell component that other modalities miss, and flu/cy conditioning takes care of this
2) CR requires eliminating all pathogenic cells, and leaving even a few enables relapse- flu/cy + CAR clears better than other tx
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Thoughts? Always wondered this myself.
Antoun Nabhan@AntounNabhan
@RobertLKruse Multiple B-cell depleters (e.g. rituximab) have been trialed in SLE. So far as I know, none have achieved complete responses. The CAR-T approach and more basic BMT approaches have. Hence, my bet would be that fly/cy ablation is important to achieving CRs.
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@RNAiAnalyst Looks like they’re reporting whole liver editing here, so it’s possible that distribution to hepatocytes vs other cells is different. They report hepatocyte editing as an estimate based on liver cellular composition on a subsequent slide
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$PRME NHP data:
44% whole liver gene editing should translate to ~70% protein expression.
Prime only sees 46%. Does this mean edits are faulty?
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@pcr_guy I always see the wildest science in your QTs, in the best way. This is awesome
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Can confirm - I used to get off the T early because it was faster to walk… What doesn’t make the headline is that wait times were often 10-15 minutes before getting on a standing room only train going slower than walking speed
Matt Stout@MattPStout
Tracks that opened for passenger service to Union Square in March 2022 and to Medford in December — and were shut down for repairs in recent months — are now so defective, the @MBTA says, that trains are moving slower than many people walk. bostonglobe.com/2023/09/26/met… via @taydolven
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@BowTiedBiotech Definitely plenty of potential but there’s a lot to do to get there - need an order of magnitude more well-curated positive and negative data from diverse cohorts to approach decent prediction
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😎 Cool paper and a future area that will be getting more and more attention go forward: that being predicting TCR-ligand interactions.
Imagine this:
1. Isolate disease tissue
2. Immuno-profile to isolate immune cells
3. TCR-seq T-cells
4. Predict antigens that cell type specific immune cells are reacting to
This is a gold mine of novel target opportunity and will DRASTICALLY expand target space
Pair this with the growing 🧰 of modalities and delivery systems and you have to future of medicine.
Diego del Alamo@DdelAlamo
"TAPIR: a T-cell receptor language model for predicting rare and novel targets" A CNN trained on ~50,000 TCR sequences that learns to generate TCR representations with a number of downstream uses biorxiv.org/content/10.110…
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