Swanee🎱
282.9K posts

Swanee🎱
@JaySwansonPool
9-Ball World Champion. Rescue a shelter or street kitty, dog, bunny, or any critter.🐱🐶🐇🐿🕊🐝🐞🐎🐗🐂🦌 🇺🇸🦅

Comprehensive Immunophenotyping of Monocytes and Dendritic Cells Suggests Distinct Pathophysiology in Chronic Fatigue Syndrome and Long COVID 🚨Interesting new decisive data confirming divergence: ME/CFS and Long COVID are NOT the same disease! ➡️This international study used multiparameter flow cytometry on peripheral blood mononuclear cells to compare immune profiles in ME/CFS (n=103), Long COVID (n=63), and healthy controls (n=41). It targeted monocytes (M1/M2-like), dendritic cells (DCs), and T-cell subsets to uncover disease-specific signatures, ➡️Long COVID Profile: - Marked by increased M2-like monocyte polarization, elevated CD80 (costimulatory marker) across monocyte subsets, DC expansion, and paradoxically reduced activation markers (e.g., CD69+CD38), - Indicates persistent immune activation combined with exhaustion features, ➡️ME/CFS Profile: - Characterized by reduced costimulatory molecule expression (e.g., lower CD80 on DCs/monocytes), impaired CCR7 expression (disrupting immune cell trafficking), and less coordinated activation patterns, consistent with immune suppression, ➡️Additional Analyses: - Correlation networks showed more extensive, integrated immune interactions in Long COVID vs. fragmented patterns in ME/CFS, - Principal component analysis (PCA) and PLS-DA revealed distinct immunophenotypic clusters, enabling moderate discrimination between the two conditions (AUC ~0.76 in moderate cases), ➡️Implications: - Age-adjusted statistics confirmed differences, - Findings point to divergent post-infectious immunopathologies rather than a shared syndrome, ➡️Conclusion: - ME/CFS and Long COVID are not the same disease, - They drive opposite immune failures, one of chronic hyper-activation tipping into exhaustion, the other of outright suppression and trafficking collapse, - Treating them as interchangeable is scientifically indefensible and clinically harmful, - Distinct biomarkers now exist: →Separate pathophysiology demands separate diagnostics and therapies! #MECFS #LongCOVID #AvoidSars2 #AvoidReinfections mdpi.com/1422-0067/27/1…

BREAKING: Mitch McConnell just slammed the Trump slush fund: "So the nation's top law enforcement official is asking for a slush fund to pay people who assault cops? Utterly stupid, morally wrong – Take your pick."

Rep. Norman: January 6th was an issue that was made up in the first place. Reporter: Made up? Norman: That was a staged thing from day one. Reporter: The riot was staged? Your Republican colleagues barricaded themselves in their chamber. You think they were acting?


We are saddened and heartbroken to share the news of the passing of Kyle Busch, a two-time Cup champion and one of our sport's greatest and fiercest drivers. He was 41 years old. We extend our deepest condolences to the Busch family, Richard Childress Racing and the entire motorsports community.


If Elon Musk is cheating our elections, why is nobody stopping him?


Ed Gallrein drew 57,053 votes in the 2026 GOP primary. That is a 351% surge in the anti-Massie vote. That is a biggest surge in U.S. election history. Massie’s vote rose 18%, from 39,929 to 47,018. Total GOP primary turnout nearly doubled in an off-year race. Money, Trump, and pro-Israel can’t explain it alone. Or maybe it can. But a 351% challenger surge is not normal. It deserves precinct-level scrutiny. I call for an audit & recount!











