Jay Brito Querido

We've just celebrated the 2nd anniversary of my lab at @UMichMedSchool, @UMLifeSciences and @umichrna. I couldn't have asked for a better gift – my first @NIH R01 Grant was awarded on my very first attempt! A total of $3.1 million to study #mRNA #translation in #neurodegeneration

@IsraelF96135088 🥶

Today we had a great result coming out of the Krios. I feel like celebration...

🌟"The thrill of asking new questions and seeing them answered... keeps the quest going." – Prof. Eva Nogales, 2023 #ShawPrize Laureate. Get ready for the 2024 ceremony!🎊 💻 Full speech: youtube.com/watch?v=PANxrH… @NogalesLab @UCBerkeley

Our lab @MRC_LMB is seeking a passionate PhD student to explore transcription-coupled splicing! Join our team for an exciting project to understand human gene regulation 🧬 Feel free to get in touch directly #PhD #cryoEM #biochemistry

Now out in peer-reviewed format at @nchembio …rdcu.be/dXhoi

I am looking for a highly talented postdoc to join my lab to study ATP-dependent AAA machines using structural biology, biochemistry, and mass spectrometry. Please apply through the following link: bit.ly/4haSZID For more information, visit: sites.wustl.edu/ghanbarpour/

Winning the @NobelPrize is the honour of a lifetime and the realisation of a lifelong dream - it still hasn’t really sunk in yet. With AlphaFold2 we cracked the 50-year grand challenge of protein structure prediction: predicting the 3D structure of a protein purely from its amino acid sequence. Proteins are the building blocks of life, and knowing the structure of a protein is crucial for understanding the function it performs. We then folded all 200 million proteins known to science and made those structures freely available for anyone in the world to use, with the help of our wonderful collaborators at @emblebi. Over 2 million researchers have already used AlphaFold2 and its predictions to advance a huge range of important work - everything from enzyme design, to disease understanding, to drug discovery. But this is only the beginning. Over the next few years AI will help us make great strides towards developing new and more effective therapies for today's most prevalent diseases, and the fantastic team at @IsomorphicLabs are making rapid progress on this mission. I can’t think of a more important or beneficial use of AI. Then of course there is advancing AGI itself, the original and enduring goal, and the vision behind the founding of DeepMind nearly 15 years ago. If AI is built safely and responsibly, I believe it will be one of the most transformative and beneficial technologies ever. I’ve always thought of AI as the ultimate tool to help us accelerate scientific discovery. Congratulations to John Jumper (and David Baker!), the amazing AlphaFold team, and all our incredible colleagues at @GoogleDeepMind and @Google that supported and encouraged us along the way - this award is for all of us! It’s been such an honour and privilege to work with all of you to advance the frontiers of AI and science, and there is so much more to come!

🚨We’re excited to feature Prof. Daniel N Wilson, a leading structural and molecular biology expert, at the New Techniques—Novel Insights session of #AdvMicro2025 👩‍🔬🧫! Discover cutting-edge insights into ribosome-targeting antibiotics and the development of new antimicrobials.

Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. @MPI_Biochem 👇👇👇

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Happy to share our little discovery with @SimoneMattei19 team on how ribosomes hibernate upside down on mitochondria during cellular stress is now out @NatureComms! A collaboration between @medicineUVA, @EMBL, @EmblImaging, MEMC. Congrats to all authors! nature.com/articles/s4146…

I look forward to hosting @mitchguttman from @Caltech for a seminar at the @UMLifeSciences. #RNA @umichrna

covercovercovercovercovercovercovercovercovercovercover this is terrifically exciting (Also please dw, the central dogma is still very much intact, this is just a bit of a funky spin on it)

Big day for neuroscience & the end of the beginning for whole brain connectomics. Shout out to @sdorkenw and Philipp Schlegel, first authors of the connectome papers, @MurthyLab @SebastianSeung for establishing #flywire to make this possible and @dddavi for birthing this dataset.

St. Jude names M. Madan Babu, PhD, as Chief Data Scientist. He’ll lead the new Office of Data Science, advancing biomedical research with 115 new roles. His work will help integrate vast datasets and improve patient care. #DataScience #BiomedicalResearch ow.ly/gQbN50TAASu

Looking back a week ... enjoyed exciting science and great fun with #UMichBiolChem family at our annual retreat in Ohio. Stay tuned - lots to come from this crowd. @UMichMedScience @UMichResearch

Part 1 of our venture into the world of alternative translation-linked proteoforms! (Now Dr) Paul Lee, Yu Sun, along w/@AlexaRSoares and others in @MarinaP63 lab found that alternative TIS pairs change the localization and functions of synaptic organizers! authors.elsevier.com/a/1jpc73vVUPRm…

If you are interested in RNA regulation, translational control, cancer progression, and/or therapy resistance... (+cookies&Shenanigans): The Conn Lab is #HiringNow for Postdoc and senior research positions @PennMedicine full description link in thread

Rockefeller's @Steve_Bonilla is developing integrative structural biology methods to visualize dynamic RNA 3D structures and understand how they regulate the life cycles of RNA viruses. #HispanicHeritageMonth

@WangXiaoLab @HongyuChenChem @LDangliang @AbhiAditham @broadinstitute @ChemistryMIT This is super cool!!! Congratulations

Chapter 2 of branched RNA: chemically modified branched cap for multi-capped mRNA and capped circular RNA (QRNA)--the cellular translation machinery is surprisingly tolerant of unnatural structures! Beyond enhanced performance, the mechanism is intriguing: rdcu.be/dUQKX