Jennifer El Tekle

And that’s a wrap! Very happy to share our review on the fascinating and multifaceted role of the microbiota in cancer. 👇 1/3 nature.com/articles/s4156…

Check out the latest pre-print from the lab! Great work led by Slater Clay @SlaterC_ Oral acetoacetate reduces tumor burden in colon cancer models by forming an MR1 ligand that boosts anti-tumor MAIT cells. biorxiv.org/content/10.110…

Our 1st Roadmap asking why do patients with cancer die? is now FREE to access for 1 month starting today! The precise causes of mortality in patients with cancer remains poorly understood & this piece starts to highlight areas of unmet need for targeting go.nature.com/3RDKlao

The antidepressant effects of exercise. 🧵1/8

Bacteria in metastatic sites: Unveiling hidden players in cancer progression dlvr.it/T9Vrt5

So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of @AriSarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.110…) 1/12

⭐Research highlight: Enzymes derived from gut bacteria switch A and B blood types to Group O (‘universal’), a strategy that could help solve blood donor shortages in the future. @NatureMicrobiol nature.com/articles/d4159…

A study in @NatureMicrobiol shows that enzymes found in the gut resident bacteria, Akkermansia muciniphila, can convert both known and previously not recognized antigens on human red blood cells to make group O blood. go.nature.com/3QLIPTh

Have you ever seen real-time footage of a tumor developing outside a living organism? We are thrilled to announce a new paradigm in ex vivo cancer modelling rdcu.be/dFD2v. Let’s have a quick look!

Very excited to share our latest work, out today in @ScienceMagazine, on the serendipitous finding that vitamin D ☀️ regulates the gut microbiome to promote cancer immunity🦠 science.org/doi/10.1126/sc… 🧵👇 @ReiseSousaLab @TheCrick

NEW content online! Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications dlvr.it/T5Fz27

Online Now: Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer dlvr.it/T56TmN

Exciting study!!

Happy to share our recent work led by postdoc @LiangChi281017 published today in @Science 🥳Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis.👇 science.org/doi/10.1126/sc…

New study: a bacteria that normally lives in the mouth was found in 50% of colon cancers. This is consistent with prior research on the interactions between the microbiome and colon cancer, which is rising among young people. nature.com/articles/s4158….

☕️In this issue: @OphirKlein, @RKZwick & co examine the mouse & human #SmallIntestine and find that both comprise 5 domains of #NutrientAbsorption and 3 regional #StemCell populations. 👉🏾rdcu.be/dyS3s nature.com/articles/s4155…

t.co/PsH4ChRlSU Great teamwork from amazing Post doctoral fellow Nori Goto and our wonderful DFCI collaborator @JudithAgudo1 showing how the earliest premalignant intestinal stem cell evade immune detection. @MITBiology @kochinstitute @DanaFarber @BIDMCpath @MGHPathology @DrMartyTaylor

We found that chronic stress increases metastasis in mice. The neutrophils are at the helm (again!). Link to our report in @Cancer_Cell: authors.elsevier.com/a/1ieO05TA51hO…

New content online: Ultra-processed foods and food additives in gut health and disease dlvr.it/T36zLv

The conneXion between sex and immune responses dlvr.it/T33mky

The gut microbiota can shape the CRC tumor microenvironment in many different ways! 🦠 Have a look at our latest review published now in @AnnualReviews. Very fun to write with @NatashAndreeva, our super smart PhD student! ✨@HarvardIID @broadinstitute @EMBOFellows