Jessica Lu

210 posts

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Jessica Lu

Jessica Lu

@Jessica_J_Lu

Postdoctoral Research Associate @BiochemOxford 🔬

Oxford, England Katılım Kasım 2019
503 Takip Edilen467 Takipçiler
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Cesare Orlandi
Cesare Orlandi@orlandi_cesare·
Our GzESTY paper is online. We optimized a cell based assay to sensitively detect GPCR activation in response to ligand application or in complex mixtures containing endogenous ligands. GzESTY was designed to aid in GPCR deorphanization efforts. nature.com/articles/s4146…
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GPCRmd
GPCRmd@GPCRmd·
🔬 The 2nd round of GPCRmd data is out! Covering 60% of GPCR structures, it reveals allosteric sites & lateral gateways into the receptor core. 🔗 Read: doi.org/10.1038/s41467… #GPCR #GPCRmd #MolecularDynamics Explore it with our new tools: #tools" target="_blank" rel="nofollow noopener">gpcrmd.org/#tools
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Membrane Protein PDB
Membrane Protein PDB@MemProtPDB·
Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function | Nat Commun doi.org/10.1038/s41467…
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Ben Myers Lab
Ben Myers Lab@Myers_lab·
Excited to share our new preprint on the #Hedgehog pathway! We uncover how #Smoothened (SMO), a noncanonical #GPCR, binds & inhibits #PKA via an intrinsically disordered region, mimicking known GPCR/PKA signaling complexes despite minimal sequence similarity. #AlphaFold #IDR
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Structure
Structure@Structure_CP·
Online now! Native mass spectrometry prescreening of G protein-coupled receptor complexes for cryo-EM structure determination dlvr.it/TFq1ht
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Charles Bayly-Jones
Charles Bayly-Jones@bj_charles·
We are thrilled beyond words to see our LYCHOS (GPR155) publication out today in @Nature. 🥳 “LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR” nature.com/articles/s4158… 🧵
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Wnt UK
Wnt UK@UK_Wnt·
📔SAVE THE DATE! 🗓️ The 2nd WntUK national meeting will be held at @WorcCollegeOx @UniofOxford on Monday 24th March 2025. Registration and abstract submission opens November 2024. Wnt researchers of all levels and disciplines welcome from the UK and beyond!
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ECI GPCR symposium
ECI GPCR symposium@cool7TMs·
Tomorrow is THE DAY! 🎉 We're kicking off the #4th_Transatlantic_ECI_GPCR_Symposium. This is the final reminder for registration! Besides the amazing keynote speakers, and career and lunch/dinner panelists, we have wonderful #ECI speakers who will present their latest research!
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Ben Myers Lab
Ben Myers Lab@Myers_lab·
Now published in @PLOSBiology: How GRK kinases control #GPCR signaling in the #Hedgehog transduction cascade in primary #cilia. journals.plos.org/plosbiology/ar…
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Ben Myers Lab@Myers_lab

Excited to present a new story focusing on how the #GPCR #SMOOTHENED activates GLI transcription factors in the primary cilium during #Hedgehog signaling! Fantastic collab with Radhika Subramanian, @GeXuecai , and many others. biorxiv.org/content/10.110…

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Keşfet

@Nature @WorcCollegeOx @UniofOxford @SarahJ_Piper @brianpcary @arc_gov_au @MIPS_Australia @Aus_ScienceWeek