Jose H. Ledo

Thrilled to share our paper "An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains" , out now in @ImmunityCP ! Thread below by the super @AlonMillet !

@bryan_johnson I have the same issue , have been treating it with cyclosporine eye drops to target the inflammation and warm compress 2x day , not back to baseline but improved a lot ...

I started milking my eyelids. Here's the situation. My eyes have been dry/irritated/red for the past year or so. I started using eye drops to moisten and it didn't make a difference. So I went to see an eye doctor. The source of the problem is that my meibomian glands, the tiny oil glands lining the eyelids, were clogged up. Without the meibum they secrete, the tear film on my eye evaporates in seconds which is bad for eye health. We're not sure of the cause of the dysregulation. We have few theories that we're looking into. Taking a closer look with infrared meibography, the imagery showed that my meibomian glands were congested, distorted, and partially dropped out. This is bad news because atrophied glands don't regrow! It's situations like this that makes me wonder why we do not have a better operating manual for the human body. How could I have prevented this from happening and why didn't I catch this sooner!? I did additional tests to assess the damage and my situation now. The Schirmer test (paper strip measuring tear wetting over 5 minutes) came back at 6 and 6.5 mm. A borderline reading consistent with mild dry eye. A healthy reading is typically 15 mm or above. Here's what I'm doing now to try and nurture my remaining glands back to good health: 1) Forma RF, Radiofrequency (microwave) heat applied from outside the lid, melting the obstruction. 2) LipiFlow, a device that sandwiches each eyelid: heat from the inside, pulsed pressure from the outside, squeezing the obstruction out. 12 minutes, both eyes. 3) Both capped at 41°C, not the standard 42°C, to spare eyelid collagen and elastin. No thinning skin, no premature sagging. 4) IPL around the eyes that shut down the abnormal blood vessels feeding chronic lid inflammation, the engine of MGD. 5) Manual gland milking, the doctor squeezes the lid margin between two instruments, forcing the plugs out. Hard, pasty secretions came out initially. The second and third mechanical milking the glands are returning to a normal, expected oily state. 6) Daily upkeep includes warm compresses, lid hygiene, omega-3 to keep secretions thin and glands moving. My next check in is 3 weeks form now. My doctor mentioned that meibomian gland dysfunction in her patients has increased since Covid, likely driven by the rise in screen time. When staring at screens for long stretches, people blink less frequently and less completely. Normal blink rate is roughly 15-20 times per minute but drops significantly during screen use. Incomplete blinks mean the meibomian glands don't get fully expressed, which over time contributes to gland dysfunction and evaporative dry eye. It's worth you getting checked for this and a good practice generally to make sure your eyes are in good health.

Microglia are such a pain. nature.com/articles/s4158…

@VeenaPadmanaban @Nature Amazing work , truly ! Super congrats !

🚨❗️🚨 New Paper Alert My postdoctoral work now out in @Nature. We find that sensory neurons drive breast cancer metastasis via an activity-dependent paracrine signalling mechanism mediated by substance-P, extracellular ssRNA & TLR7 receptor. (1/11) urldefense.com/v3/__https://w…$ 🧵👇🏾

Super excited to share that we've got funding from @alzassociation to test a new therapeutical strategy for AD ! Big thanks to @alzassociation for this awesome opportunity! #ALZFunded

Good opportunity for Senior PhD students and post docs

Senescent glia link mitochondrial dysfunction and lipid accumulation | Nature nature.com/articles/s4158…

@Giovann35084111 Eventually they will understand , may take sometime though. Keep up the great work sir .

#Bitcoin the adoption of Bitcoin doesn't happen because of some perceived scarcity. It happens because it is a mind virus. It follows a constant rate. Once you are infected you want it, no matter the price. Everybody gets the price they deserve and they deserve the Bitcoin that they can afford. But you deserve it because you finally got it, no matter if soon or later. You want it not because it is scarce, but because it is valuable. It is not toilet paper during corona virus. It is an insult to say Bitcoin is valuable because it is scarce. It is 1000 things more important and useful than scarce. Scarcity plays no role in Bitcoin.

Cutting-edge miniature two-photon microscopy follows the structural dynamics of microglia in the somatosensory cortex of freely moving mice across the sleep/wake cycle. elifesciences.org/articles/86749…

Congrats to my friend Mauricio @Mauricio_Neuro and @KlannLab , great work guys !🚀

So happy for @Mauricio_Neuro, whose paper was published over the weekend. He shows how eIF2alpha becomes dephosphorylated in response to neuronal stimulation, answering a long-standing question in the field. cell.com/cell-reports/f…. Congratulations Mauricio!

@KlannLab @Mauricio_Neuro Great Job Mauricio and Klann Lab !! You guys are rock stars ! 🚀

TIMely connections: APOE4, aging, and Alzheimer’s: Immunity cell.com/immunity/fullt… Very Nice Preview of our work by Qingyun Li. @ImmunityCP

An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains dlvr.it/T1CNcP

@andrebafica @ImmunityCP @AlonMillet Thanks a lot irmao !

Thrilled to share our paper "An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains" , out now in @ImmunityCP ! Thread below by the super @AlonMillet !

@LukensJohnR @AlonMillet Thanks a lot , John @LukensJohnR ! Wishing you a fantastic 2024 !

@AlonMillet Congrats on the fantastic work

An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains: Immunity cell.com/immunity/fullt…

@neuro_MUSC 🔥🚀🎉

@SchaferLabUMass @ImmunityCP @AlonMillet Many Thanks @SchaferLabUMass !!

@Jhledo @ImmunityCP @AlonMillet Cool! Look forward to reading!

@Mauricio_Neuro Thanks a lot mano ! 🤟🏽🤟

Brilliant paper by my friend @Jhledo and colleagues!

@danmucida @ImmunityCP @AlonMillet Thanks a lot mano véi !🙌🙌🏽