Judith Strymish

In this large cohort of veterans with CIEDs, 4.7% developed a BSI; CIED device involvement occurred in 17.2% of patients and was most commonly associated with other evidence of severe disseminated infections, such as endocarditis or osteomyelitis. academic.oup.com/ofid/article/1…

🆕⚡🧬 How Long Is Long Enough? — CBP Antibiotic Durations Still Built on Sand | CMI Communications, 2025 🚀 Methods 📚 Systematic Review of global literature (1946–2025) on ABx durations for chronic bacterial prostatitis (CBP). 🧪 Included RCTs + Obs cohorts; outcomes = clinical failure ≤6 mo. 💊 Drugs: FQs, TMP-SMX, fosfomycin; durations 2–12 wks. 🧑‍⚕️ PRISMA + Prospero; RoB: NOS & RoB-2. 🔥 Findings 🗂️ 9/69 studies included; poor quality. 💊 6 RCTs w/ ≥1 arm by duration: 1175 pts; 3 Obs studies: 223 pts → total 1397 pts. 📊 Durations: 4 wks = 82%, 2–3 wks = 15%, ≥6 wks = 3%. 📉 Clinical failure: <3 wks → 50%, 4 wks → 19%, ≥6 wks → 20%. ❗ No head-to-head RCTs: 4 vs 6 wks FQs/TMP-SMX; no fosfomycin vs FQ trials. 🫙 Evidence gap: only 174 pts (2 wks), 67 pts (3 wks), 44 pts (≥6 wks). ⚠️ Limitations 🧪 Small, heterogenous studies. 💥 Nonuniform CBP defs & outcomes; 27% missing outcomes. 🌍 No international standard for microbiologic/clinical endpoints. 💡 Takeaway Current 4–6 wk FQ/TMP-SMX CBP regimens = thin evidence. Data mostly 4 wks (82%), shorter/longer durations poorly supported. Proper RCTs with ≥6-mo FU urgently needed. #IDXposts sciencedirect.com:5037/science/articl…

For us ID doctors, the CDC has been a rock. Data, guidelines, surveillance, travel advice -- all there, vetted by experts, referenced, reliable. Perfect? No. But watching its dismantling now breaks my heart. Some thoughts: blogs.jwatch.org/hiv-id-observa…

Implementation of Diagnostic Stewardship to Improve Urinary Tract Infection Antibiotic Use Across Three Medical Centers ✅ Just Accepted bit.ly/4kWS3s1

In @CIDJournal, @ClaeysKcclaeys and colleagues examined interventions for urine culture ordering, processing, and reporting across three diverse Veterans Affairs (VA) hospitals and evaluated the interventions’ impact on antimicrobial use. academic.oup.com/cid/advance-ar…

In this study that included 42067 adults in 🇺🇸, long-acting lipoglycopeptides (laLGPs) were effective as step-down treatment of serious gram +ve bacterial infections, offering comparable outcomes (readmission/ED visit/90d inpatient☠️) vs SOC antibiotics doi.org/10.1001/jamane…

@tony_breu @rbganatra

Does anyone know why bezlo was discontinued? Seems no reason given? @mmPharmD

Rates of post procedural prophylactic antibiotic use following cardiac implantable electronic device insertion and … pubmed.ncbi.nlm.nih.gov/39695877/ 🫀 Good news: declining rate of use. Bad news: use in 40% of patients. Keflex chaser most commonly used. @MayoClinicINFD @MayoClinicCV

Executive Summary: State-of-the-Art Review: Evaluation and Management of Pelvic Osteomyelitis in Stage IV Pressure Injuries: A Multidisciplinary Collaborative Approach bit.ly/47FGU9K

@BrighamWomens Nocardia

A major worldwide software outage has affected many of our systems at Mass General Brigham, as well as many major businesses across the country. Due to the severity of this issue, all previously scheduled non-urgent surgeries, procedures, and medical visits are cancelled today. Mass General Brigham remains open to provide care to patients with urgent health concerns in our clinics and emergency departments, and we continue to care for all patients currently receiving care in our hospitals. We have dedicated every available resource to resolve this issue as quickly as possible, and we apologize for the inconvenience this has caused our patients. It is our highest priority to ensure that our patients receive the safest care possible.

In 2 weeks! 😍

Viewpoint discusses the @US_FDA’s authorization of marketing an at-home testing system for chlamydia and gonorrhea as a good first step in boosting access to screening and treatment and in reducing infection rates. ja.ma/3UEwfX5

🔥DOTS🔥 The most anticipated RCT #ESCMIDGLOBAL2024 Dalbavancin is non-inferior to SOC by clinical efficacy for complicated SAB incl Rt sided IE 2 doses Dalba 1500 mg on days 1 & 8 or 4-8 wks of SOC(cefaz or naf:MSSA;vanc or dapto:MRSA) DOOR at D70 Slides shared by @LordAlirezaF

Lets talk about Antibiotic PK. This week's 🧵: Distribution! This is where the drug goes after it's absorbed/injected. Where it goes = what target sites it can be used at. Main drug factors: Hydrophilic vs Lipophilic, plasma protein binding, and peripheral tissue binding 1/9

Hospitals testing for C diff using “flipped algorithm” of PCR -> toxin appear “better” in public reporting with less risk of financial penalty. BUT, these hospitals only publicly report 37% of patients who received treatment for C diff. cambridge.org/core/journals/…

A #Mustread 🔥 #IDXposts EnJoY

Is the practice of preoperative urine culture associated with 🔽 risk of postoperative UTI or SSI? Hopefully,the results of this 🆕️🔥study can change the potentially harmful practice of urine testing & antibiotic use in asymptomatic pts prior to surgery! jamanetwork.com/journals/jaman…

Asymptomatic Testing of Hospital Admissions for SARS-CoV-2: Is it OK to Stop? 🆓 Freely Available bit.ly/3wnhsHv