Julie Heffler

Our collaboration with Ben Prosser’s lab, led jointly by @AmiadDaria and @julieheffler, is finally published! We show how reducing cytoskeletal forces on the nucleus of Lmna mutant cardiomyocytes reduces nuclear envelope rupture, improves cardiacs function, and survival.

Quantifying cardiomyocyte contraction & nuclear deformation interaction reveals nucleus-damaging mechanism underlying LMNA cardiomyopathy 📷 @AmiadDaria & @julieheffler et al @WeillCornell @PennMedicine in @NatureCVR ➡️ bpod.org.uk/archive/2025/1…

.@JulieHeffler and @LammerdingLab @CornellBME discuss recent studies from the @Schliekerlab (hubs.la/Q03D99x00) and @hennelab (hubs.la/Q03D99zV0) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. hubs.la/Q03D97M70

We are going to lose an entire generation of scientists. NSF, one of the largest federal funder of STEM education has seen an 80% reduction in funding, including support for trainees, so far this year. “You can’t have science without scientists”

Major breakthrough in pancreatic cancer . Funded of course by the @NIH

NIH funding creates medicines, jobs, and economic growth

Just spent 30 hours reviewing for an NIH study section set for Thurs—now postponed indefinitely. 20 other scientists did the same X multiple sections. Huge waste of time, resources, and funding, with real costs for science and economy. @realDonaldTrump admin is bad for everyone.

How do cells squeeze their large nucleus through tight spaces? In work now published at @J_Cell_Sci, we show that cancer cells can use contraction of the rear cortex to generate pressure in the back and push the nucleus during confined #migration: journals.biologists.com/jcs/article-ab…

The lab at work! Great team effort in preparing sequencing libraries to study nuclear #mechanotransduction. Stay tuned for exciting results coming up!

@MCaporizzo Looks amazing!

Excited that our Airyscan is up and running! Resolving collagen fibers to about 150 nm resolution.

Hello! The Lammerding Lab @CornellBME and @weillinstitute is now on Twitter! Here is what you can expect from this account: highlights of our #mechanobiology work, pretty fluorescent images and videos, gushing over our team members, and more. Follow us!

Intermediate filaments dressed up in my favorite colormap (🔥glow). This is a Cos7 transfected with mApple-tagged vimentin. I gamma adjusted the movie to visualize the lower density filaments moving out towards the periphery.

Mitotic rounding. XY (left) and XZ (right) views.

@thomashawke Great idea! I might just steal that 👀 usually I just store the work books with the data but would probably be an additional level of organization

@julieheffler Truth🙏. My new policy for trainees is - every graph/image you make must include a text footnote of the original data file name where I can retrieve it when you graduate!

#1 piece of house keeping advice I’d give grad students is organize/label your data and samples as much as possible. I know it’s a pain sometimes but when you’re trying to find that one piece of data from 5 yrs ago you’ll thank yourself (or conversely hate yourself like me..😭)

@RobertMauck11 @Prosser_Lab Oh no I’m never escaping shrinkled huh? 😅😂

Congrats Dr. Julie Heffler @julieheffler @Prosser_Lab on an amazing thesis defense. And for coining the new word ‘Shrinkled’. Outstanding work! So grateful to have been a part of this and cannot wait to see what you will do next. Huzzah!

Dr. Heffler 😎

@Chris_W_Ward @Prosser_Lab thank you! we're still not quite sure but we have some interesting ideas. Like Ben said that's going to be a "to be continued" portion of the talk 😉

@Prosser_Lab @julieheffler Ha! Good luck @julieheffler !!

Tomorrow! @julieheffler is a terrific speaker, with a particular gift and emphasis on conveying the significance of her work to a broad audience. Come see Julie dominate her defense! #ProudPI

Julie Heffler @julieheffler from Ben Prosser's lab @Prosser_Lab defends tomorrow.

My defense is in less than a week. So nervous and excited 😬😭✨