Henne_Lab
2.7K posts
@HenneLab
Cell Biology lab at UTSW @UTSWNews. We study lipid droplets and the organization of metabolism in cells.
Excited to share our new paper in @FEBSJournal! With @OndrejKuda & @FedorovaLab we show how LDs reshape the lipidome of PUFA-exposed cells & shift function within the same cell, revealing a context-dependent role in ferroptosis. Congrats Ana & @Lejaperne! shorturl.at/TyRl1
1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳 nature.com/articles/s4158…
1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳 nature.com/articles/s4158…
Tubulin acetylation governs organelle remodeling and lysosomal reformation during neuronal differentiation biorxiv.org/content/10.648… #biorxiv_cellbio
Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13
STING drives inflammation and aging pathology. Today, @Nature, we show that PI(3,5)P₂ is an endogenous ligand that cooperates with cGAMP to trigger STING activation — revealing a new nexus for disease intervention. Here is the PDF rdcu.be/e2lVI
New preprint from the lab! Triglycerides act like salt on ice: they solubilize cholesterol esters and drive lipid droplet growth. The TG/CE ratio shapes both droplet size and proteome, mirroring lipoprotein organization. biorxiv.org/content/10.648…
