Kara Dunne-Dombrink

A new #Primer from @KomorLab, @KDombrink, @benrpollak on #BaseEditing, a method for precise genome editing through programmable single-base changes. Base editing has application in high-throughput screening, disease modeling, and therapeutics. 🧬nature.com/articles/s4358…

Great work by Dr. Mallory Evanoff (& collaborators) from our lab !!

Honored to be featured 👩‍🔬 National science funding is so important for my research and for clinical studies !!

Congratulations to @UCSDChemBiochem Professor Alexis Komor for receiving the Young Innovator Award from Advanced Science @KomorLab @AdvancedPortfolioNews! 🎉

Amazing work exemplifying how base editing can be personalized to treat deadly rare diseases! nejm.org/doi/pdf/10.105…

The NIH helped sequence the human genome & develop life-saving therapies. Now it's being defunded. As an NIH-trained scientist, this is heartbreaking. Investing in biomedical research isn’t optional—it’s how we fight disease & save lives. #FundScience #NIH

Delighted to see our work published in @angew_chem! Thanks to all of our fantastic collaborators for making this work possible

“I can’t wait to start my new life.” Kendric Cromer, a 12-year-old boy, became one of the first children ever to be treated with a newly approved gene therapy that will free him from the sickle cell disease that has stolen his childhood. nyti.ms/4gulKiO

Today we report in @natBME the systematic application of six recent prime editing developments to enable efficient and functional correction of CFTR F508del, the predominant mutation that causes cystic fibrosis (CF), in primary airway cells from CF patients. drive.google.com/file/d/1A7wKca… (1/6)

@LFMPassalacqua Congrats Luiz!! So exciting 🧬

Thrilled to share our groups' new SEE-CITE photoaffinity labeling methodology where we installed a silyl cleavable linker between the diazirine and MOI to enable head-to-head interactomics. Spearheaded by Sho Takechi and Chau Ngo and now up on @ChemRxiv chemrxiv.org/engage/chemrxi…

Excited my PhD work is out now @NatureBiotech! We report Multiplexed Orthogonal Base Editor (MOBE) systems: tools to simultaneously install distinct point mutations. MOBEs introduce co-occurring genetic variants (polygenic disease, haplotypes)🧬 🧵⬇️ 1/ go.nature.com/3K8Kfn1

New paper out from the lab! pubs.acs.org/doi/full/10.10…

Congrats to Dr. Cowan @Quinn_Cowan_sci who just defended his thesis! He aptly celebrated the occasion with a lei made of the flow cells from his HTS runs. Be on the lookout for his paper, which is coming out soon! 👀🎉

The first prime editing clinical trial has been cleared by @US_FDA to begin: prime editing of HSCs to treat chronic granulomatous disease (CGD). Congratulations to @PrimeMedicine on achieving this key milestone only 4.5 years after we published the first prime editing paper.

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology. PDF: drive.google.com/file/d/18hu15h… 1/13

Congratulations to @HugoMedinaMunoz, @EricKofman et al in our paper describing systematic evaluation and nomination of RNA base editors for RNA binding protein-RNA interactome studies. #rna #RBPs #genomics link.springer.com/10.1038/s41467…

The FDA has approved a powerful medicine that uses the gene-editing tool CRISPR to treat sickle cell disease The devastating illness affects more than 100,000 Americans, the majority of whom are Black nbcnews.com/health/health-…

Johnny Lubin was one of the youngest patients in the clinical trial supporting today’s approval of the first CRISPR treatment in the US, one of two therapies approved today for sickle cell. He told us how the therapy has changed his life:

Delighted to announce the publication of my work with @srivsesh and my PI @jschneek at @NAR_Open. In this work, we unlock the mysteries of i-motifs and their binding partners using DNA microarrays. Special thanks to @Mo46647245, and our collaborators in the Vinson lab.