Konstantin Kaganovsky

369 posts

Konstantin Kaganovsky banner
Konstantin Kaganovsky

Konstantin Kaganovsky

@KaganovskyNeuro

Postdoc in @Sergiu_P_Pasca Lab | @SudhofThomas @BJunDing @yavinshaham lab alumnus | Trying to do good science while raising little ones | Grateful immigrant

Stanford/NIDA/UCSB Katılım Ağustos 2019
408 Takip Edilen410 Takipçiler
Sabitlenmiş Tweet
Konstantin Kaganovsky
Konstantin Kaganovsky@KaganovskyNeuro·
Very excited to share my first preprint! It began as a tool development project that overturned our hypotheses/humbled us when we dug into the role of LTP in learning. The💡moment came when the second-to-none @MarkPlitt tied it all together at the systems level.
English
4
7
53
0
Konstantin Kaganovsky retweetledi
Sergiu P. Pasca
Sergiu P. Pasca@Sergiu_P_Pasca·
Consider joining us at Stanford as a postdoctoral fellow! If you have a published paper or a preprint, will graduate in the next period, and are excited to work in California, email me your CV and a brief statement of your research interests and trajectory by the end of August. No prior experience in stem cells, organoids, or assembloids needed (we generally recruit outside of the field). There are no preset projects—just come ready to tackle important questions in human brain development and disease.
Sergiu P. Pasca tweet media
English
15
98
346
52.7K
Konstantin Kaganovsky retweetledi
Sergiu P. Pasca
Sergiu P. Pasca@Sergiu_P_Pasca·
Our latest work is out today in @ScienceMagazine: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development. This was achieved with human midline #assembloids by combining floor plate and spinal cord #organoids from pluripotent stem cells. A key advance is the three-part configuration (a floor plate squeezed in between two spinal cords), which enables human axons to cross the midline (and the subsequent synchronization of activity between the two parts seen in the video below). This platform opens the door to many applications; here, we used it to screen and identify human-enriched midline crossing regulators. Work led by @massimo_onesto with Neal Amin
English
6
23
135
10.2K
Konstantin Kaganovsky retweetledi
Sergiu P. Pasca
Sergiu P. Pasca@Sergiu_P_Pasca·
Excited to announce that applications are now open for the Asilomar meeting on The Ethical and Societal Implications of Neural Organoids, Assembloids, and Their Transplantation, taking place this November. As the technologies and applications of neural #organoids & #assembloids continue to evolve, a number of ethical and societal issues are emerging. This meeting supported by the Dana Foundation and our Stanford @BrOrganogenesis Center will bring together scientists, ethicists, patient advocates, and science communicators for an open conversation. Looking forward to co-organizing this with @HankGreelyLSJU. Grateful to have such an extraordinary group joining us 👇
Sergiu P. Pasca tweet media
English
1
16
63
7.9K
Konstantin Kaganovsky retweetledi
Sergiu P. Pasca
Sergiu P. Pasca@Sergiu_P_Pasca·
Our 2024 CSHL conference on human brain development and stem cell models is in full swing, with over 300 participants! This year’s event features exciting new discoveries and dynamic discussions, driven largely by the energy & insights of trainees. A privilege to organize this meeting with Guo-Li Ming @UPenn_SongMing! #Assembloids #Organoids #Brain #CSHL2024Brain
Sergiu P. Pasca tweet media
English
0
13
78
6K
Konstantin Kaganovsky retweetledi
HB lab🔬⚡🧠🌏🌍
HB lab🔬⚡🧠🌏🌍@hb_cell·
I am no lord of any kind, but I assert here with all I have learned, this finding here is one (of the two or many) cloud that shadows the canonical neuroscience that 🧠memories are formed by synaptic plasticity. Keep this tweet and come back in 20 yrs. nature.com/articles/s4159…
HB lab🔬⚡🧠🌏🌍 tweet mediaHB lab🔬⚡🧠🌏🌍 tweet media
English
3
14
55
11K
Konstantin Kaganovsky retweetledi
Sergiu P. Pasca
Sergiu P. Pasca@Sergiu_P_Pasca·
Today we report in @CellStemCell a systematic approach to generate neural #organoids resembling various domains of the neural axis. @neal_amin & @kevinwkelley developed a multiplexed morphogen screen to generate hundreds of #organoids that ultimately transcriptionally mapped to almost 2/3 of the clusters in the 1st trimester human CNS Also led to generating surprising cell types, including the primate-enriched TAC3 neurons or Purkinje cells of the cerebellum (more on that soon) Check out the paper and summary below
Sergiu P. Pasca tweet media
English
4
24
113
24.8K
Konstantin Kaganovsky
Konstantin Kaganovsky@KaganovskyNeuro·
Tour de force systematically generating an incredible diversity of regionalized organoids. Grateful to contribute to this large effort driven by @kevinwkelley and @neal_amin in @Sergiu_P_Pasca lab.
Kevin Kelley@kevinwkelley

Great to see our paper online! Amazing collaboration with @neal_amin over the years. With invaluable input from @KaganovskyNeuro, @massimo_onesto, Jin, Yuki, @jamespmcqueen, Noah, and others in @Sergiu_P_Pasca group.

English
0
2
8
1.8K
Konstantin Kaganovsky retweetledi
Kevin Kelley
Kevin Kelley@kevinwkelley·
Great to see our paper online! Amazing collaboration with @neal_amin over the years. With invaluable input from @KaganovskyNeuro, @massimo_onesto, Jin, Yuki, @jamespmcqueen, Noah, and others in @Sergiu_P_Pasca group.
Sergiu P. Pasca@Sergiu_P_Pasca

Today we report in @CellStemCell a systematic approach to generate neural #organoids resembling various domains of the neural axis. @neal_amin & @kevinwkelley developed a multiplexed morphogen screen to generate hundreds of #organoids that ultimately transcriptionally mapped to almost 2/3 of the clusters in the 1st trimester human CNS Also led to generating surprising cell types, including the primate-enriched TAC3 neurons or Purkinje cells of the cerebellum (more on that soon) Check out the paper and summary below

English
3
9
25
5K
Konstantin Kaganovsky retweetledi
Malcolm Campbell
Malcolm Campbell@malcgcamp·
Excited to share our updated preprint on the neural basis of foraging decisions! This work was co-led by Michael Bukwich (twitterless, now at UCL) and me, with major contributions from co-authors, and the incredible animation is by @KJHerr23. (1/12) biorxiv.org/content/10.110…
English
1
24
70
13.2K
Konstantin Kaganovsky retweetledi
Sergiu P. Pasca
Sergiu P. Pasca@Sergiu_P_Pasca·
Today we introduce human neural loop #assembloids created from 4 parts derived from stem cells to study the cortico-striato-midbrain-thalamo-cortical pathway and to model neurodevelopmental disease Work led by the remarkable Ji-Il Kim and Yuki Miura in the lab. Also in collaboration with the @marius10p lab at @HHMIJanelia Video shows a four-part neural assembloid displaying emergent synchronized activity after a couple of hundred days of integration
English
14
35
192
27.4K
Konstantin Kaganovsky
Konstantin Kaganovsky@KaganovskyNeuro·
Interested in the intersection of brain organoids and bioelectronics? I highly recommend working with my colleague @XiaoYang63 when she opens her lab at Hopkins next year! Rigorous thinker who's passion for science shines through
Xiao Yang@XiaoYang63

Thrilled to share that I will join @JohnsHopkins @JHUBME as an Assistant Professor in 2025! The Yang Lab will develop novel bioelectronics and biomaterials for brain-machine interfaces, regenerative medicine, and the study of human neural development and diseases.

English
1
1
9
1.4K
Konstantin Kaganovsky retweetledi
Anne Carpenter, PhD
Anne Carpenter, PhD@DrAnneCarpenter·
Took 1-8y off science for family during your postdoc or faculty position? Contact an NIH-funded lab to see if they will write a reentry with you. Please RT these little-known supplements: nigms.nih.gov/Research/Mecha…
English
2
193
236
45.8K
Konstantin Kaganovsky retweetledi
McGill University
McGill University@mcgillu·
In the 1950s Brenda Milner changed the course of 🧠brain science by identifying the specific brain region crucial to memory formation and by identifying multiple memory systems. Today we celebrate her 106th! Happy Birthday Brenda Milner!🎂🎉 mcgill.ca/x/wYY
English
2
52
235
31.4K
Konstantin Kaganovsky retweetledi
Chunyang (Jason) Dong
Chunyang (Jason) Dong@JasonCDong1·
Today we present precise detection of endogenous opioids using genetically encoded biosensors. Multiple early variants have been validated in labs, and we have now optimized, determined, and benchmarked the first-gen opioid sensors for both in vitro and in vivo applications.
Lin Tian, PhD@LinTianPhD

New paper out in @NatureNeuro! Collaborating with several labs, we developed genetically encoded biosensors to track opioid pharmacology in the brain & provide powerful new tools for dissecting complex circuit-specific dynamics 🔧🧠 nature.com/articles/s4159…

English
10
9
78
10K
Konstantin Kaganovsky retweetledi
Sergiu P. Pasca
Sergiu P. Pasca@Sergiu_P_Pasca·
Cells located in the midline of the embryo play crucial roles in development. These cells often influence cell fate decisions and guide axons to establish bilateral connections. Despite their importance, studying these transient cells and their complex interactions has been challenging. Today, we introduce human midline #assembloids—3D self-organizing cellular clusters derived from stem cells by the functional integration of floor plate #organoids and spinal cord #organoids. We demonstrate that midline assembloids enable cell specification and axon guidance in human neurons. Additionally, we use these assembloids to screen and identify human-enriched factors that control these processes. Work led by the incredible @massimo_onesto & @neal_amin!! More details in the preprint 👇
English
5
38
158
15.8K

Keşfet

@ScienceMagazine @massimo_onesto @BrOrganogenesis @HankGreelyLSJU @UPenn_SongMing @CellStemCell @neal_amin @kevinwkelley