Manil Kanade

Very happy to share our latest work in @JMolBiol. We report the identification of a new motif related to Walker B motif in an ancestral prokaryotic Ras-like GTPase. Congratulations to all co-authors @Sukanya_Gemini @SanketS57292043 Biology @IISERPune doi.org/10.1016/j.jmb.…

When particles have orientation bias, the resulting maps are often streaked along the missing directions. In this case study, we cover why orientation bias produces anisotropic #cryoEM maps and how you may be able to recover from it! guide.cryosparc.com/processing-dat…

New online! Cell cycle regulation has shaped replication origins in budding yeast bit.ly/4erd1h3

Preprint of @omics_lab’s recent web server & API toolkit is online now. #HOToffthePress Read it here: researchsquare.com/article/rs-658… ---------------- Try this tool using this link and let us know your suggestions: project.iith.ac.in/sharmaglab/alp…

@DebnathGhosal Amazing work, Debnath! Congratulations!

Delighted to share our recent work. This is a "Story of a dwarf predator". ❄️❄️🦠🗡️🔬❄️❄️ nature.com/articles/s4146…

We are excited to present the first #cryoEM structures of human GABA transporter 3 – GAT3 – bound to an in-house selective inhibitor, SR-THAP, to substrate GABA, and in the substrate-free state! @biorxivpreprint biorxiv.org/content/10.110…

We are excited to share our latest publication in Nature! Led by our outstanding postdoc, Taha Shahid, & PhD student, Ammar Danazumi, our study reveals how the SV40 LTag helicase melts and translocates on DNA, driven by an entropy-switch mechanism. nature.com/articles/s4158…

@De_Biasio_group Congratulations, Alfredo! Amazing work!

@itskrishnendu3 @TPucadyil @NatureComms Congrats Krishnendu 😊

Happy to share a part of my PhD work in @TPucadyil lab now online @NatureComms. In collaboration with Joshua Pemberton and Tamas Balla, we show how local production of lipids on #mitochondrial surface regulates the activity of membrane shaping proteins. #citeas" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…

HISTORICAL MOMENT FOR INDIAN CHESS 🇮🇳 Gukesh D Is World Chess Champion 👑🥹

A novel cryo-EM affinity-grid approach utilizing monodispersed single-particle streptavidin on a lipid monolayer is introduced to improve particle absorption, thereby addressing challenges like preferential angular distribution rdcu.be/d1MNM @eBIC_Diamond @OxfordStrubi

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m

Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online @Nature! 🎉 Our findings reveal that unlike in yeast, human MCM loading does not require ORC6 and can occur through multiple pathways. Read more here: rdcu.be/d1F6S

I‘m happy to share our work on laser flash melting to overcome preferred orientation in cryo-EM samples! 🥳❄️🔬 More infos on the underlying mechanism of particle redistribution and the use for preferred orientation issues in the 🧵 or here: biorxiv.org/content/10.110…

@muktajoshi03 Congrats Mukta 😃

It has been a long journey with this one, but finally happy to see the last paper from my PhD published in Insect Systematics and Diversity 🎉 academic.oup.com/isd/article/8/…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

@SusanKilgas @NatureComms Congrats Susan 👏

Really happy to share my first author paper from my postdoc published in @NatureComms ! 🥳 A huge thank you to our collaborators and all the contributing authors of the paper!

Thrilled to share our latest paper on RTEL1! Huge shoutout to our first author @GiuseppeCortone. The work uncovers the structural and biochemical properties of RTEL1's C-terminal region, highlighting its crucial role in genome stability and DNA repair🧬 onlinelibrary.wiley.com/doi/full/10.10…

How are DNA-protein crosslinks like camptothecin-induced TOP1ccs resolved? Check it out in our freshly baked @NatureComms paper: nature.com/articles/s4146… @duxin_lab

We're thrilled to announce our new preprint on the structure of the human alternative clamp loader, CTF18, bound to PCNA. A big shoutout to our star PhD student @BriolaGiusy for spearheading this work! biorxiv.org/content/10.110… #DNAReplication

@Joyeechakra Congrats Joyeeta 😃

Delighted to share our work, recently published in @jbiolchem Check it out here- Dynamics of interdomain rotation facilitates FtsZ filament assembly - Journal of Biological Chemistry jbc.org/article/S0021-…